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4. Modelling Survival Data in Medical Research
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This article is published in Journal of The Royal Statistical Society Series A-statistics in Society.The article was published on 1995-01-01. It has received 1092 citations till now. The article focuses on the topics: Medical research.read more
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Mineral Metabolism, Mortality, and Morbidity in Maintenance Hemodialysis
Geoffrey A. Block,Preston S. Klassen,J. Michael Lazarus,Norma J. Ofsthun,Edmund G. Lowrie,Glenn M. Chertow +5 more
TL;DR: Hyperphosphatemia and hyperparathyroidism were significantly associated with all-cause, cardiovascular, and fracture-related hospitalization, and the population attributable risk percentage for disorders of mineral metabolism was 17.5%, owing largely to the high prevalence of hyperph phosphatemia.
Journal ArticleDOI
Overall Survival and Updated Results for Sunitinib Compared With Interferon Alfa in Patients With Metastatic Renal Cell Carcinoma
Robert J. Motzer,Thomas E. Hutson,Piotr Tomczak,M. Dror Michaelson,Ronald M. Bukowski,Stéphane Oudard,Sylvie Negrier,Cezary Szczylik,Roberto Pili,Georg A. Bjarnason,Xavier Garcia-del-Muro,Jeffrey A. Sosman,Ewa Solska,George Wilding,John A. Thompson,Sindy T. Kim,Isan Chen,Xin Huang,Robert A. Figlin +18 more
TL;DR: Sunitinib demonstrates longer overall survival compared with IFN-alpha plus improvement in response and progression-free survival in the first-line treatment of patients with metastatic RCC, highlighting an improved prognosis in patients with RCC in the era of targeted therapy.
Journal ArticleDOI
Neoadjuvant Chemotherapy or Primary Surgery in Stage IIIC or IV Ovarian Cancer
Ignace Vergote,Claes G. Tropé,Frédéric Amant,G.B. Kristensen,Tom Ehlen,N Johnson,René H.M. Verheijen,Maria E. L. van der Burg,A. J. Lacave,Pierluigi Benedetti Panici,Gemma G. Kenter,Antonio Casado,Cesar Mendiola,Corneel Coens,Leen Verleye,Gavin Stuart,Sergio Pecorelli,Nicholas Reed +17 more
TL;DR: Neoadjuvant chemotherapy followed by interval debulking surgery was not inferior to primary debulked surgery followed by chemotherapy as a treatment option for patients with bulky stage IIIC or IV ovarian carcinoma in this study.
Journal ArticleDOI
Survival and Prognostic Stratification of 670 Patients With Advanced Renal Cell Carcinoma
TL;DR: Five prognostic factors for predicting survival were identified and used to categorize patients with metastatic RCC into three risk groups, for which the median survival times were separated by 6 months or more.
References
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Journal ArticleDOI
Low-grade gliomas in older patients: a retrospective analysis of prognostic factors
Nader Pouratian,Melike Mut,Jay Jagannathan,M. Beatriz S. Lopes,Mark E. Shaffrey,David Schiff +5 more
TL;DR: Patients presented in equal numbers with seizure, focal neurological deficit, and mental status change, and Younger age, seizure presentation, and radiation treatment were prognostic of OS on multivariate analysis, suggesting that age should not affect the management of LGG patients.
Journal Article
Is herpes zoster a marker for occult or subsequent malignancy
TL;DR: The results do not justify extensive testing for cancer in herpes zoster patients and leaves open a number of questions with respect to the physiopathology behind it.
Journal ArticleDOI
Correlation between egfr expression and accelerated proliferation during radiotherapy of head and neck squamous cell carcinoma
Piernicola Pedicini,Antonio Nappi,Lidia Strigari,Barbara Alicia Jereczek-Fossa,Barbara Alicia Jereczek-Fossa,Daniela Alterio,Marta Cremonesi,Francesca Botta,Barbara Vischioni,Rocchina Caivano,Alba Fiorentino,Giuseppina Improta,Giovanni Storto,Marcello Benassi,Roberto Orecchia,Roberto Orecchia,Marco Salvatore +16 more
TL;DR: To quantify the extent of the effect which EGFr expression has in terms of reduced TD and Dprolif for each head and neck sub-site, the dose that would be required to offset the modified proliferation occurring in one day (Dprolif), was estimated.
Journal ArticleDOI
Failure Event Prediction Using Hidden Markov Model Approaches
TL;DR: It is shown that the degradation level provided by the HMM approach is more efficient than the survival functions approach, and a four-state, left to right, HMM topology can represent the degradationlevel of a system.
Journal ArticleDOI
The addition of artesunate to chloroquine for treatment of Plasmodium falciparum malaria in Gambian children delays but does not prevent treatment failure.
Colin J. Sutherland,Chris Drakeley,Uche Obisike,Rosalind Coleman,Musa Jawara,Geoffrey A. T. Targett,Paul Milligan,Margaret Pinder,Gijs Walraven +8 more
TL;DR: Chloroquine plus artesunate is not sufficiently efficacious to justify its introduction as a replacement for chloroquine monotherapy in The Gambia, and the impact of combination therapy on the transmission ofchloroquine-resistant parasites is discussed.