Assessing the fitness consequences of mitonuclear interactions in natural populations.
Geoffrey E. Hill,Justin C. Havird,Daniel B. Sloan,Ronald S. Burton,Chris Greening,Damian K. Dowling +5 more
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TLDR
The modes by which mitochondrial and nuclear genomes may coevolve within natural populations are outlined, and the implications of mitonuclear coadaptation for diverse fields of study in the biological sciences are discussed.Abstract:
Metazoans exist only with a continuous and rich supply of chemical energy from oxidative phosphorylation in mitochondria. The oxidative phosphorylation machinery that mediates energy conservation is encoded by both mitochondrial and nuclear genes, and hence the products of these two genomes must interact closely to achieve coordinated function of core respiratory processes. It follows that selection for efficient respiration will lead to selection for compatible combinations of mitochondrial and nuclear genotypes, and this should facilitate coadaptation between mitochondrial and nuclear genomes (mitonuclear coadaptation). Herein, we outline the modes by which mitochondrial and nuclear genomes may coevolve within natural populations, and we discuss the implications of mitonuclear coadaptation for diverse fields of study in the biological sciences. We identify five themes in the study of mitonuclear interactions that provide a roadmap for both ecological and biomedical studies seeking to measure the contribution of intergenomic coadaptation to the evolution of natural populations. We also explore the wider implications of the fitness consequences of mitonuclear interactions, focusing on central debates within the fields of ecology and biomedicine.read more
Citations
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Clinical application of pronuclear transfer to prevent mitochondrial DNA disease
TL;DR: In this article, pronuclear transplantation was used to reduce mtDNA carryover to <2% in the majority (79%) of PNT blastocysts, with no detectable effect on aneuploidy or gene expression.
Journal ArticleDOI
Power, sex, suicide Mitochondria and the meaning of life
TL;DR: To the typical reader of the JCI, the word mitochondria likely evokes a Pavlovian response remembered vaguely from biochemistry class: they are “the powerhouses of the cell.”
Journal ArticleDOI
Integrating Mitochondrial Aerobic Metabolism into Ecology and Evolution
Rebecca E. Koch,Katherine L. Buchanan,Stefania Casagrande,Ondi L. Crino,Damian K. Dowling,Geoffrey E. Hill,Wendy R. Hood,Matthew McKenzie,Mylene M. Mariette,Daniel W. A. Noble,Alexandra Pavlova,Frank Seebacher,Paul Sunnucks,Eve Udino,Craig R. White,Karine Salin,Antoine Stier,Antoine Stier +17 more
TL;DR: In this article, the authors explore how mitochondrial aerobic metabolism influences different aspects of organismal performance, such as through changing adenosine triphosphate (ATP) and reactive oxygen species (ROS) production.
Journal ArticleDOI
Selfish Mitonuclear Conflict
Justin C. Havird,Evan S. Forsythe,Alissa M. Williams,John H. Werren,Damian K. Dowling,Daniel B. Sloan +5 more
TL;DR: Recent advances in understanding selfish replication and sexual antagonism in the evolution of mitochondrial genomes and the mechanisms that suppress selfish interactions are reviewed, drawing parallels and contrasts with other organelles (plastids) and bacterial endosymbionts that arose more recently.
Journal ArticleDOI
Strong selective effects of mitochondrial DNA on the nuclear genome.
TL;DR: The most fit hybrids were those with nuclear alleles that matched their mitochondrial genotype on these chromosomes, suggesting that mitonuclear effects underlie individual-level variation in developmental rate and that intergenomic compatibility is critical for high fitness.
References
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Sperm competition and its evolutionary consequences in the insects
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Rapid evolution of animal mitochondrial DNA.
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Wolbachia: master manipulators of invertebrate biology.
TL;DR: The basic biology of Wolbachia is reviewed, with emphasis on recent advances in the authors' understanding of these fascinating endosymbionts, which are found in arthropods and nematodes.
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The whole structure of the 13-subunit oxidized cytochrome c oxidase at 2.8 A.
Tomitake Tsukihara,Hiroshi Aoyama,Eiki Yamashita,Takashi Tomizaki,Hiroshi Yamaguchi,Kyoko Shinzawa-Itoh,Ryosuke Nakashima,Rieko Yaono,Shinya Yoshikawa +8 more
TL;DR: Two possible proton pathways for pumping, each spanning from the matrix to the cytosolic surfaces, were identified, including hydrogen bonds, internal cavities likely to contain water molecules, and structures that could form hydrogen bonds with small possible conformational change of amino acid side chains.