Journal ArticleDOI
Biologic and pharmacologic regulation of mammalian glutathione synthesis.
TLDR
Because GSH plays a critical role in cellular defenses against electrophiles, oxidative stress and nitrosating species, pharmacologic manipulation of GSH synthesis has received much attention.About:
This article is published in Free Radical Biology and Medicine.The article was published on 1999-11-01. It has received 1120 citations till now. The article focuses on the topics: Glutathione & Buthionine sulfoximine.read more
Citations
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Inhibition of Glutathione Synthesis via Decreased Glucose Metabolism in Stored RBCs.
Yanlian Xiong,Yanlei Xiong,Yueming Wang,Zhuoya Wang,Aiping Zhang,Nannan Zhao,Dongmei Zhao,Zhenhai Yu,Zhiqiang Wang,Junzhu Yi,Xiying Luan +10 more
TL;DR: Oxidant stress-induced dysfunction in glucose metabolism was the driving force for decreased GSH synthesis during storage, and an underlying molecular mechanism that oxidant stress induced glucose metabolism dysfunction contribute to decreased G SH synthesis in stored RBCs is reflected.
Journal ArticleDOI
Searching for synergism: effects of combinations of phenolic compounds and other toxins on oxidative stress in Lymantria dispar caterpillars
TL;DR: The results of this study do not support the hypothesis that the combined effects of phenolic compounds and other toxins in sugar maple leaves produce a synergistic increase in oxidative stress in L. dispar larvae.
Journal ArticleDOI
Control of amino acid transport into Chinese hamster ovary cells
Darren Geoghegan,Claire L. Arnall,Diane Hatton,Joanne Noble-Longster,Christopher A. Sellick,Tarik Senussi,David C. James +6 more
TL;DR: This study comparatively characterized AAT expression in untransfected and monoclonal antibody‐producing CHO cells using transcriptome analysis by RNA‐seq, and mechanistically dissected AAT function using a variety of transporter‐specific chemical inhibitors, comparing their effect on cell proliferation, recombinant protein production, and amino acid transport.
Journal ArticleDOI
Sublethal health effects in laboratory rodents from environmentally relevant exposures to oil sands contaminants
TL;DR: It is proposed that wild small mammals will prove to be valuable sentinel species reflecting sublethal health effects from oil sands-related contaminants and provide reliable and sensitive measures of the response to contaminant exposure in a mammalian model, suggesting associated physiological costs.
Nutritional influence on oxidative stress in global ischemia
TL;DR: Findings from these two studies suggest well-nourished but not nutritionally-deficient rodents tolerate a mild brain insult, and the effect of PEM on brain oxidative stress, neural damage and behaviour after global ischemia in adult male gerbils.
References
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The metabolic basis of inherited disease
TL;DR: The metabolic basis of inherited disease, the metabolic basis for inherited disease as mentioned in this paper, The metabolic basis in inherited disease and inherited diseases, and inherited disease diagnosis and management, in the context of inherited diseases
Journal ArticleDOI
Antioxidant and Redox Regulation of Gene Transcription
Chandan K. Sen,Lester Packer +1 more
TL;DR: The efficacy of different antioxidants to favorably influence the molecular mechanisms implicated in human disease should be a critical determinant of its selection for clinical studies.
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Efficacy of oral N-acetylcysteine in the treatment of acetaminophen overdose. Analysis of the national multicenter study (1976 to 1985)
TL;DR: It is concluded that N-acetylcysteine treatment should be started within eight hours of an acetaminophen overdose, but that treatment is still indicated at least as late as 24 hours after ingestion, and it may be superior when treatment is delayed.