Journal ArticleDOI
Biologic and pharmacologic regulation of mammalian glutathione synthesis.
TLDR
Because GSH plays a critical role in cellular defenses against electrophiles, oxidative stress and nitrosating species, pharmacologic manipulation of GSH synthesis has received much attention.About:
This article is published in Free Radical Biology and Medicine.The article was published on 1999-11-01. It has received 1120 citations till now. The article focuses on the topics: Glutathione & Buthionine sulfoximine.read more
Citations
More filters
Journal ArticleDOI
Exogenous coenzyme Q10 modulates MMP-2 activity in MCF-7 cell line as a breast cancer cellular model
Massih Bahar,Shahnaz Khaghani,Parvin Pasalar,Maliheh Paknejad,Mohammad Reza Khorramizadeh,Hossein Mirmiranpour,Siavash Gerayesh Nejad +6 more
TL;DR: The results showed that both coenzyme Q10 and N-acetyl-L-cysteine reduce MMP-2 activity along with the pro-oxidant capacity of the MCF-7 cell in a dose proportionate manner.
Journal ArticleDOI
Buthionine Sulfoximine Has Anti-Trypanosoma cruzi Activity in a Murine Model of Acute Chagas' Disease and Enhances the Efficacy of Nifurtimox
Mario Faúndez,Mario Faúndez,Rodrigo López-Muñoz,Gloria Torres,Antonio Morello,Jorge Ferreira,Ulrike Kemmerling,Myriam Orellana,Juan Diego Maya +8 more
TL;DR: L-Buthionine (S,R)-sulfoximine at a dose of 220 mg/kg of body weight/day showed an anti-Trypanosoma cruzi effect in infected mice, increasing their survival rate and decreasing the parasitemias and parasite burden in the hearts.
Journal ArticleDOI
The hepatic and skeletal muscle ovine metabolomes as affected by weight loss: a study in three sheep breeds using NMR-metabolomics
Mariana Palma,Tim Scanlon,Tanya Kilminster,John Milton,C. M. Oldham,Johan Greeff,Manolis Matzapetakis,André M. Almeida +7 more
TL;DR: In this article, the liver and muscle metabolomes were assessed by 1H-NMR and showed that the Damara and Dorper sheep exhibited higher tolerance to nutritional scarcity, whereas the Merinos exhibited more differences between treatment groups.
BookDOI
Gasotransmitters: Physiology and Pathophysiology
TL;DR: This chapter will describe principles of NO biosynthesis, regulatory mechanisms controlling the production of this molecule, and the large array of (physiologic and pathophysiologic) functions that Mother Nature has assigned to this small messenger molecule.
Journal ArticleDOI
Increased efflux of glutathione conjugate in acutely diabetic cardiomyocytes.
Sanjoy Ghosh,Simon Ting,Howard C.S. Lau,Thomas Pulinilkunnil,Ding An,Dake Qi,Mohammed A. Abrahani,Brian Rodrigues +7 more
TL;DR: Reduction in myocyte GSH in diabetic rats was accompanied by increased oxidative stress, excessive reactive oxygen species, and an elevated apoptotic cell death, but the effect on GSH was not associated with any change in either synthesis or recycling.
References
More filters
Book
The metabolic basis of inherited disease
TL;DR: The metabolic basis of inherited disease, the metabolic basis for inherited disease as mentioned in this paper, The metabolic basis in inherited disease and inherited diseases, and inherited disease diagnosis and management, in the context of inherited diseases
Journal ArticleDOI
Antioxidant and Redox Regulation of Gene Transcription
Chandan K. Sen,Lester Packer +1 more
TL;DR: The efficacy of different antioxidants to favorably influence the molecular mechanisms implicated in human disease should be a critical determinant of its selection for clinical studies.
Journal ArticleDOI
Efficacy of oral N-acetylcysteine in the treatment of acetaminophen overdose. Analysis of the national multicenter study (1976 to 1985)
TL;DR: It is concluded that N-acetylcysteine treatment should be started within eight hours of an acetaminophen overdose, but that treatment is still indicated at least as late as 24 hours after ingestion, and it may be superior when treatment is delayed.