Journal ArticleDOI
Biologic and pharmacologic regulation of mammalian glutathione synthesis.
TLDR
Because GSH plays a critical role in cellular defenses against electrophiles, oxidative stress and nitrosating species, pharmacologic manipulation of GSH synthesis has received much attention.About:
This article is published in Free Radical Biology and Medicine.The article was published on 1999-11-01. It has received 1120 citations till now. The article focuses on the topics: Glutathione & Buthionine sulfoximine.read more
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Journal ArticleDOI
Mice lacking the glutamate-cysteine ligase modifier subunit are susceptible to myocardial ischaemia-reperfusion injury.
Tsuyoshi Kobayashi,Yosuke Watanabe,Yukio Saito,Daisuke Fujioka,Takamitsu Nakamura,Jun-ei Obata,Yoshinobu Kitta,Toshiaki Yano,Ken-ichi Kawabata,Kazuhiro Watanabe,Hideto Mishina,Sadahiro Ito,Kiyotaka Kugiyama +12 more
TL;DR: GCLM(-/-) mice were susceptible to myocardial ischaemia-reperfusion I/R injury partly through an increased vulnerability of mitochondria to oxidative damage owing to mitochondrial GSH reduction.
Journal ArticleDOI
The Pro-Oxidant Activity of Pheomelanin is Significantly Enhanced by UVA Irradiation: Benzothiazole Moieties Are More Reactive than Benzothiazine Moieties.
TL;DR: UVA enhances the pro-oxidant activity of pheomelanin, in particular BZ-PM, which suggests that the redox reactions may proceed via singlet oxygen in Bz-AA and via superoxide anions in DHBTCA.
Journal ArticleDOI
Cadmium-induced elevations in the gene expression of the regulatory subunit of γ-glutamylcysteine synthetase in rat lung and alveolar epithelial cells
G.S. Shukla,J.-F. Chiu,B.A. Hart +2 more
TL;DR: Cd-induced up-regulation of gamma-GCS-LS mRNA expression in alveolar epithelial cells exposed to Cd in vitro, either acutely or after repeated passaging in Cd-containing medium may offer protection from Cd toxicity.
Journal ArticleDOI
Assessment of tumor redox status through (S)-4-(3-[18F]fluoropropyl)-L-glutamic acid positron emission tomography imaging of system xc-activity
Patrick McCormick,Hannah E. Greenwood,Matthias Glaser,Oliver D. K. Maddocks,Thibault Gendron,Kerstin Sander,Gayatri Gowrishankar,Aileen Hoehne,Tong Zhang,Adam J. Shuhendler,David Y. Lewis,Mathias Berndt,Norman Koglin,Mark F. Lythgoe,Sanjiv S. Gambhir,Erik Årstad,Timothy H. Witney +16 more
TL;DR: It is shown that tumor cell retention of a system xc --specific PET radiotracer, (S)-4-(3-[18F]fluoropropyl)-L-glutamic acid ([ 18F]FSPG), decreases in proportion to levels of oxidative stress following treatment with a range of redox-active compounds.
Journal ArticleDOI
A nutrient-dense, high-fiber, fruit-based supplement bar increases HDL cholesterol, particularly large HDL, lowers homocysteine, and raises glutathione in a 2-wk trial
Michele L. Mietus-Snyder,Mark K. Shigenaga,Jung H. Suh,Swapna V. Shenvi,Ashutosh Lal,Tara H. McHugh,Donald A. Olson,Joshua Lilienstein,Ronald M. Krauss,Ginny L. Gildengoren,Joyce C. McCann,Bruce N. Ames +11 more
TL;DR: A nutrient‐dense, high‐fiber, fruit‐based supplement bar increases HDL cholesterol, particularly large HDL, lowers homocysteine, and raises glutathione in a 2‐wk trial, laying the groundwork for mechanistic/deconstruction experiments to identify critical bar components and putative synergistic combinations responsible for observed effects.
References
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The metabolic basis of inherited disease
TL;DR: The metabolic basis of inherited disease, the metabolic basis for inherited disease as mentioned in this paper, The metabolic basis in inherited disease and inherited diseases, and inherited disease diagnosis and management, in the context of inherited diseases
Journal ArticleDOI
Antioxidant and Redox Regulation of Gene Transcription
Chandan K. Sen,Lester Packer +1 more
TL;DR: The efficacy of different antioxidants to favorably influence the molecular mechanisms implicated in human disease should be a critical determinant of its selection for clinical studies.
Journal ArticleDOI
Efficacy of oral N-acetylcysteine in the treatment of acetaminophen overdose. Analysis of the national multicenter study (1976 to 1985)
TL;DR: It is concluded that N-acetylcysteine treatment should be started within eight hours of an acetaminophen overdose, but that treatment is still indicated at least as late as 24 hours after ingestion, and it may be superior when treatment is delayed.