Journal ArticleDOI
Biologic and pharmacologic regulation of mammalian glutathione synthesis.
TLDR
Because GSH plays a critical role in cellular defenses against electrophiles, oxidative stress and nitrosating species, pharmacologic manipulation of GSH synthesis has received much attention.About:
This article is published in Free Radical Biology and Medicine.The article was published on 1999-11-01. It has received 1120 citations till now. The article focuses on the topics: Glutathione & Buthionine sulfoximine.read more
Citations
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Journal ArticleDOI
Aging: Thromboembolic Disease, Metabolic Syndrome, Type 2 Diabetes Mellitus, and Alzheimer's Disease
Joaquín Lasierra-Cirujeda,María José Aza Pascual-Salcedo,Alicia Lasierra-Ibañez,Carmen Lasala Aza,María Mercedes Aza Pascual-Salcedo +4 more
TL;DR: The results suggest the hypothesis of the importance of a therapeutic strategy using the inhibition of PAI-1 as a goal, because it is increased in the different aging pathologic processes.
Book ChapterDOI
Redox Regulatory Circuits as Targets for Therapeutic Intervention of Bancroftian Filariasis: Biochemical, Molecular, and Pharmacological Perspectives
TL;DR: This chapter has discussed the recent advancements and potential of redox regulation targeted intervention of lymphatic filariasis by majorly emphasizing the biochemical, molecular, and pharmacological perspectives.
Journal ArticleDOI
Inhibition of Glutathione S-Transferase by Ethacrynic Acid Augments Ischemia-Reperfusion Damage and Apoptosis and Attenuates the Positive Effect of Ischemic Postconditioning in a Bilateral Acute Hindlimb Ischemia Rat Model.
Tibor Nagy,Viktória Kovács,Péter Hardi,Tünde Gyöngyvér Veres,Ildikó Takács,Gábor Jancsó,László Sínay,Gábor Fazekas,Örs Pintér,Endre Arató +9 more
TL;DR: Inhibition of GST by EA augmented the IR damage, regulating these pathways in the process of apoptosis and PC, and the ratio of phosphorylated PSP was higher in the EA-administered groups and the protective effect of PC did not develop.
Journal ArticleDOI
l-glycine and l-glutamic acid protect Pediococcus pentosaceus R1 against oxidative damage induced by hydrogen peroxide.
TL;DR: In this article, the effects of l -glycine (Gly) and l -glutamic acid (Glu) on oxidative damage induced by hydrogen peroxide (H2O2) in Pediococcus pentosaceus R1 were investigated.
Dissertation
Tetrahydrobioterin and nitric oxide metabolism.
TL;DR: The results of this thesis suggest that increased NO formation can lead to decreased BH4 availability, which in turn may limit NO formation and lead to alterations in GSH status and impaired complex I activity.
References
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Book
The metabolic basis of inherited disease
TL;DR: The metabolic basis of inherited disease, the metabolic basis for inherited disease as mentioned in this paper, The metabolic basis in inherited disease and inherited diseases, and inherited disease diagnosis and management, in the context of inherited diseases
Journal ArticleDOI
Antioxidant and Redox Regulation of Gene Transcription
Chandan K. Sen,Lester Packer +1 more
TL;DR: The efficacy of different antioxidants to favorably influence the molecular mechanisms implicated in human disease should be a critical determinant of its selection for clinical studies.
Journal ArticleDOI
Efficacy of oral N-acetylcysteine in the treatment of acetaminophen overdose. Analysis of the national multicenter study (1976 to 1985)
TL;DR: It is concluded that N-acetylcysteine treatment should be started within eight hours of an acetaminophen overdose, but that treatment is still indicated at least as late as 24 hours after ingestion, and it may be superior when treatment is delayed.