Journal ArticleDOI
Biologic and pharmacologic regulation of mammalian glutathione synthesis.
TLDR
Because GSH plays a critical role in cellular defenses against electrophiles, oxidative stress and nitrosating species, pharmacologic manipulation of GSH synthesis has received much attention.About:
This article is published in Free Radical Biology and Medicine.The article was published on 1999-11-01. It has received 1120 citations till now. The article focuses on the topics: Glutathione & Buthionine sulfoximine.read more
Citations
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Journal Article
Evaluation of Mesenchymal Stem Cells and Vitamin E in Treatment of Infertile Male Albino Rats
TL;DR: Stem cells significantly increased of SOD in testes, LH and total antioxidant in serum, fructose in semen and fix all disruption caused by induction of infertility, while vitamin E was less effective than stem cells.
Journal ArticleDOI
Comparison of N-acetyl-L-cysteine and L-cysteine in respect to their transmembrane fluxes
TL;DR: It is demonstrated that cysteine crosses the erythrocyte membranes more efficiently as compared to N-acetyl-L-cysteine and is a better thiol precursor for the cells and thus better supports the intracellular glutathione synthesis.
Journal Article
Role of Glutathione in male infected with giardiasis
TL;DR: The results showed significant decrease (P<0.05) in Glutathione in G. lamblia infection patients in compared to control group, which is a positive sign for diagnosis of infection with this parasite.
Dissertation
An in vitro investigation of the antitumour efficacy of novel hybrids containing artemisinin, porphyrin, or naphthalimide derivatives /
TL;DR: In vitro oxygen availability modulates the effect of artesunate on HeLa cells ................. 28 2.6.7 Aims and objectives of this study ................................................................................ 26 Chapter 2.0.
Journal ArticleDOI
Effects of protein and/or energy restriction for six weeks on antioxidation capacity of plasma and gastrointestinal epithelial tissues of weaned kids
Z. H. Sun,Z. H. Sun,Zhixiong He,Q. L. Zhang,Zhiliang Tan,X.F. Han,Shaoxun Tang,C.S. Zhou,M. Wang,E.P. Zhang +9 more
TL;DR: Compared with antioxidation capacity of the plasma in control group, energy restriction decreased, however, the SOD activities of the jejunum mucosa in ER, PR and EPR, GR activities of jejunu mucosa, and the S OD mRNA level of theJejunum Mud still remained lower than normal.
References
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Book
The metabolic basis of inherited disease
TL;DR: The metabolic basis of inherited disease, the metabolic basis for inherited disease as mentioned in this paper, The metabolic basis in inherited disease and inherited diseases, and inherited disease diagnosis and management, in the context of inherited diseases
Journal ArticleDOI
Antioxidant and Redox Regulation of Gene Transcription
Chandan K. Sen,Lester Packer +1 more
TL;DR: The efficacy of different antioxidants to favorably influence the molecular mechanisms implicated in human disease should be a critical determinant of its selection for clinical studies.
Journal ArticleDOI
Efficacy of oral N-acetylcysteine in the treatment of acetaminophen overdose. Analysis of the national multicenter study (1976 to 1985)
TL;DR: It is concluded that N-acetylcysteine treatment should be started within eight hours of an acetaminophen overdose, but that treatment is still indicated at least as late as 24 hours after ingestion, and it may be superior when treatment is delayed.