Journal ArticleDOI
Biologic and pharmacologic regulation of mammalian glutathione synthesis.
TLDR
Because GSH plays a critical role in cellular defenses against electrophiles, oxidative stress and nitrosating species, pharmacologic manipulation of GSH synthesis has received much attention.About:
This article is published in Free Radical Biology and Medicine.The article was published on 1999-11-01. It has received 1120 citations till now. The article focuses on the topics: Glutathione & Buthionine sulfoximine.read more
Citations
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Dissertation
Biochemical effects of thermal stress in a tropical teleost fish Etroplus suratensis Bloch 1790
Susan Joy,Babu Philip +1 more
Journal ArticleDOI
Effects of kainic acid on glutatione and nitrite in rat hippocampus
TL;DR: It is concluded that in kainic acid treated rats oxidative stress could be present even after a single treatment, which could be a potentially pathogenic factor for further brain damages.
Journal ArticleDOI
Implications for the Metabolic Fate of Oral Glutamine Supplementation within Plasma and Erythrocytes of Patients with Sickle Cell Disease: A Pharmacokinetics Study.
Claudia R. Morris,Frans A. Kuypers,R. Ward Hagar,Sandra Larkin,Lisa Lavrisha,Augusta J. Saulys,Elliott Vichinsky,Jung H. Suh +7 more
TL;DR: In this paper , a pharmacokinetics (pK) study was performed to determine the metabolic fate of glutamine supplementation on plasma and erythrocyte amino acids in patients with SCD.
Journal ArticleDOI
Detoxification mechanisms in autism spectrum disorders
TL;DR: The sulphur redox-related abnormalities indicate that mercury and lead intoxication was associated with increased oxidative stress and decreased detoxification capacity, which could help in tailoring a combined treatment strategy that could help to reduce the increased prevalence of the disorder.
Journal ArticleDOI
Influence of oral glutamine and glucose on markers of oxidative stress in a paraquat rat model
Csele vand Sand,Tiago O. Vieira,Tiago Bittencourt de Oliveira,Danilo Wilhelm Filho,Fátima Regina Mena Barreto Silva,Tânia Beatriz Creczynski-Pasa +5 more
TL;DR: In the presence of all metabolic interactions, an organ-specific effect of substrate administration is shown, the G ln optimized plasma glutathione, protecting the hepatic tissue against oxidative damages.
References
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Book
The metabolic basis of inherited disease
TL;DR: The metabolic basis of inherited disease, the metabolic basis for inherited disease as mentioned in this paper, The metabolic basis in inherited disease and inherited diseases, and inherited disease diagnosis and management, in the context of inherited diseases
Journal ArticleDOI
Antioxidant and Redox Regulation of Gene Transcription
Chandan K. Sen,Lester Packer +1 more
TL;DR: The efficacy of different antioxidants to favorably influence the molecular mechanisms implicated in human disease should be a critical determinant of its selection for clinical studies.
Journal ArticleDOI
Efficacy of oral N-acetylcysteine in the treatment of acetaminophen overdose. Analysis of the national multicenter study (1976 to 1985)
TL;DR: It is concluded that N-acetylcysteine treatment should be started within eight hours of an acetaminophen overdose, but that treatment is still indicated at least as late as 24 hours after ingestion, and it may be superior when treatment is delayed.