Journal ArticleDOI
Biologic and pharmacologic regulation of mammalian glutathione synthesis.
TLDR
Because GSH plays a critical role in cellular defenses against electrophiles, oxidative stress and nitrosating species, pharmacologic manipulation of GSH synthesis has received much attention.About:
This article is published in Free Radical Biology and Medicine.The article was published on 1999-11-01. It has received 1120 citations till now. The article focuses on the topics: Glutathione & Buthionine sulfoximine.read more
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Artocarmitin B enhances intracellular antioxidant capacity via activation of Nrf2 signaling pathway in human lung epithelial cells
Xue-Yi Wu,Xue-Mei Chen,Ming-Xing Zhou,Hui-Xin Hu,Jiao-Zhen Zhang,Xiao-Ning Wang,Dong-Mei Ren,Hong-Xiang Lou,Tao Shen +8 more
TL;DR: The results indicate that ACB is a novel Nrf2 activator and enhances intracellular antioxidant capacity in human lung epithelial cells.
Journal ArticleDOI
Modulation of Liver l-γ-Glutamyl-l-cysteinylglycine Homeostasis By N-Acetyl-Glucosamine-thiazolidine-4(R)-carboxylic Acid in Mice
TL;DR: GlcNAcCys can modulate liver GSH homeostasis, which may be related to its ability to induce glutamylcysteine ligase catalytic subunit transcription, and has potential hepatoprotective properties by increasing GSH content, increasing GST activity.
Journal ArticleDOI
The glutathione-related detoxication responses to juvenile and ecdysone hormones in Galleria mellonella.
TL;DR: The results show that while ecdysone hormone has a negative effect on the glutathione-related detoxication capacity of G. mellonella, the juvenile hormones has a positive effect on this process.
Journal ArticleDOI
Advanced Age and Neurotrauma Diminish Glutathione and Impair Antioxidant Defense after Spinal Cord Injury
Andrew N. Stewart,Ethan P. Glaser,Caitlin A. Mott,William M. Bailey,Patrick G. Sullivan,Samir P. Patel,John C. Gensel +6 more
TL;DR: It is suggested that GSH levels at acute stages of SCI play a minimal role in age- dependent outcomes reported after SCI in mice, and elements of injury occurring after three dpi, such as inflammation, as key regulators of age-dependent effects.
References
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The metabolic basis of inherited disease
TL;DR: The metabolic basis of inherited disease, the metabolic basis for inherited disease as mentioned in this paper, The metabolic basis in inherited disease and inherited diseases, and inherited disease diagnosis and management, in the context of inherited diseases
Journal ArticleDOI
Antioxidant and Redox Regulation of Gene Transcription
Chandan K. Sen,Lester Packer +1 more
TL;DR: The efficacy of different antioxidants to favorably influence the molecular mechanisms implicated in human disease should be a critical determinant of its selection for clinical studies.
Journal ArticleDOI
Efficacy of oral N-acetylcysteine in the treatment of acetaminophen overdose. Analysis of the national multicenter study (1976 to 1985)
TL;DR: It is concluded that N-acetylcysteine treatment should be started within eight hours of an acetaminophen overdose, but that treatment is still indicated at least as late as 24 hours after ingestion, and it may be superior when treatment is delayed.