Journal ArticleDOI
Biologic and pharmacologic regulation of mammalian glutathione synthesis.
TLDR
Because GSH plays a critical role in cellular defenses against electrophiles, oxidative stress and nitrosating species, pharmacologic manipulation of GSH synthesis has received much attention.About:
This article is published in Free Radical Biology and Medicine.The article was published on 1999-11-01. It has received 1120 citations till now. The article focuses on the topics: Glutathione & Buthionine sulfoximine.read more
Citations
More filters
Journal ArticleDOI
The role of the inhibition of glutathione-S-transferase in the protective mechanisms of ischemic postconditioning.
Borbála Balatonyi,Balázs Gasz,Viktória Kovács,János Lantos,Gábor Jancsó,Nandor Marczin,Erzsébet Rőth +6 more
TL;DR: GST inhibition markedly increased the apoptosis and decreased the cell viability despite IPoC, and the protective effect of IPeC was lost in GST-inhibited groups for all MAPKs and GSK-3β.
Journal ArticleDOI
Kinetic studies of the oxidation of glutathione in protein refolding buffer
TL;DR: GSH oxidation could be facilitated upon the addition of copper (II) ion whereas GSH oxidation was found to be decelerated when EDTA was present and in kinetic analysis, the reaction orders of G SH oxidation under various conditions were determined.
Journal ArticleDOI
Study of the relationship between extracellular superoxide and glutathione production in batch cultures of Escherichia coli
TL;DR: It is shown that, under the conditions of a gradual decrease in dissolved oxygen (dO2), characteristic of batch culture, the global regulatory system ArcB/ArcA can play an important role in the coordinated control of extracellular superoxide and GSH fluxes and their interaction with intracellular antioxidant systems.
Journal ArticleDOI
Peperomin E and its orally bioavailable analog induce oxidative stress-mediated apoptosis of acute myeloid leukemia progenitor cells by targeting thioredoxin reductase.
TL;DR: PepE and DMAPE have similar potential to eliminate primary APCs, with no substantial toxicities to the normal cells in vitro and in vivo, and support the further preclinical investigations on PepE (DMAPE)-related therapies for the treatment of relapsed AML.
Journal ArticleDOI
Changes in GSH-antioxidant system induced by daunorubicin in human normal and diabetic fibroblasts.
TL;DR: It is indicated that daunorubicin efficiently affects the GSH antioxidant defense system both in normal and diabetic fibroblasts leading to disturbances in glutathione content as well as in the activity of GSH-related enzymes.
References
More filters
Book
The metabolic basis of inherited disease
TL;DR: The metabolic basis of inherited disease, the metabolic basis for inherited disease as mentioned in this paper, The metabolic basis in inherited disease and inherited diseases, and inherited disease diagnosis and management, in the context of inherited diseases
Journal ArticleDOI
Antioxidant and Redox Regulation of Gene Transcription
Chandan K. Sen,Lester Packer +1 more
TL;DR: The efficacy of different antioxidants to favorably influence the molecular mechanisms implicated in human disease should be a critical determinant of its selection for clinical studies.
Journal ArticleDOI
Efficacy of oral N-acetylcysteine in the treatment of acetaminophen overdose. Analysis of the national multicenter study (1976 to 1985)
TL;DR: It is concluded that N-acetylcysteine treatment should be started within eight hours of an acetaminophen overdose, but that treatment is still indicated at least as late as 24 hours after ingestion, and it may be superior when treatment is delayed.