Journal ArticleDOI
Biologic and pharmacologic regulation of mammalian glutathione synthesis.
TLDR
Because GSH plays a critical role in cellular defenses against electrophiles, oxidative stress and nitrosating species, pharmacologic manipulation of GSH synthesis has received much attention.About:
This article is published in Free Radical Biology and Medicine.The article was published on 1999-11-01. It has received 1120 citations till now. The article focuses on the topics: Glutathione & Buthionine sulfoximine.read more
Citations
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Journal ArticleDOI
Non-covalent anchoring of oligonucleotides on single-walled carbon nanotubes via short bioreducible linker
TL;DR: A novel, simple and convenient approach to assemble non-covalent hybrids of carbon nanotubes with therapeutic oligonucleotides immobilized by means of biodegradable linker is described and can be useful for the design of carbon Nanotubes-based nanoconstructions and biomaterials.
Journal ArticleDOI
Effect of cadmium and glutathione on malic enzyme activity in brown shrimps (Crangon crangon) from the Gulf of Gdańsk
TL;DR: It is demonstrated that Cadmium inhibits ME activity from shrimp muscle, and that GSH and albumin can reduce this cadmium-inhibited NADP-dependent malic enzyme activity.
Journal ArticleDOI
Upregulation of cellular glutathione levels in human ABCB5- and murine Abcb5-transfected cells
Shingo Kondo,Keita Hongama,Kengo Hanaya,Ryota Yoshida,Takaaki Kawanobe,Kazuhiro Katayama,Kohji Noguchi,Yoshikazu Sugimoto +7 more
TL;DR: The results suggest that ABCB5/Abcb5 upregulates cellular glutathione levels to protect cells from various poisons.
Book ChapterDOI
Hydrogen Sulfide-Mediated Cellular Signaling and Cytoprotection
TL;DR: This review focuses on the production of H2S from D-cysteine and polysulfides as possible signaling molecules derived from H2 S in astrocytes, which surround neuronal synapses and modulate their activity.
Journal ArticleDOI
Roles of amino acid derivatives in the regulation of obesity
TL;DR: In this paper, a review of amino acid derivatives and possible mechanisms responsible for their anti-obesity effects is presented, which mainly include inhibiting adipogenesis, increasing lipolysis, promoting brown/beige adipose tissue (BAT) development and improving glucose metabolism.
References
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Book
The metabolic basis of inherited disease
TL;DR: The metabolic basis of inherited disease, the metabolic basis for inherited disease as mentioned in this paper, The metabolic basis in inherited disease and inherited diseases, and inherited disease diagnosis and management, in the context of inherited diseases
Journal ArticleDOI
Antioxidant and Redox Regulation of Gene Transcription
Chandan K. Sen,Lester Packer +1 more
TL;DR: The efficacy of different antioxidants to favorably influence the molecular mechanisms implicated in human disease should be a critical determinant of its selection for clinical studies.
Journal ArticleDOI
Efficacy of oral N-acetylcysteine in the treatment of acetaminophen overdose. Analysis of the national multicenter study (1976 to 1985)
TL;DR: It is concluded that N-acetylcysteine treatment should be started within eight hours of an acetaminophen overdose, but that treatment is still indicated at least as late as 24 hours after ingestion, and it may be superior when treatment is delayed.