Journal ArticleDOI
Biologic and pharmacologic regulation of mammalian glutathione synthesis.
TLDR
Because GSH plays a critical role in cellular defenses against electrophiles, oxidative stress and nitrosating species, pharmacologic manipulation of GSH synthesis has received much attention.About:
This article is published in Free Radical Biology and Medicine.The article was published on 1999-11-01. It has received 1120 citations till now. The article focuses on the topics: Glutathione & Buthionine sulfoximine.read more
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Upregulation of capacity for glutathione synthesis in response to amino acid deprivation: regulation of glutamate-cysteine ligase subunits.
Angelos K. Sikalidis,Kevin M. Mazor,Jeong-In Lee,Heather B. Roman,Lawrence L. Hirschberger,Martha H. Stipanuk +5 more
TL;DR: Upregulation of GCLC and GLCM levels in response to low cysteine levels may serve to protect the cell in the face of a future stress requiring GSH as an antioxidant or conjugating/detoxifying agent.
Journal ArticleDOI
Adrenomedullin Regulates Cellular Glutathione Content via Modulation of γ-Glutamate-Cysteine Ligase Catalytic Subunit Expression
Jee-Youn Kim,Ji-Hye Yim,Jin-Ho Cho,Jin-Hwan Kim,Jeong-Hun Ko,Su-Mi Kim,Seungjoon Park,Jae-Hoon Park +7 more
TL;DR: It is shown that AM increases gamma-glutamate-cysteine ligase (gamma-GCL) activity under both hypoxic and normoxic conditions, resulting in an up-regulation of cellular glutathione levels to more than 2-fold higher than basal expression, which may explain, in part, the mechanism by which AM protects cells against oxidative stress.
Journal ArticleDOI
S-1-propenylmercaptocysteine protects murine hepatocytes against oxidative stress via persulfidation of Keap1 and activation of Nrf2.
Restituto Tocmo,Kirk L. Parkin +1 more
TL;DR: The onion-derived metabolite, S-1-propenylmercaptocysteine (CySSPe), protects against oxidative stress and exhibits anti-inflammatory effects by modulating cellular redox homeostasis as discussed by the authors.
Journal Article
Reduction of oxidative DNA fragmentation by ascorbic acid, zinc and N-acetylcysteine in nasal mucosa tissue cultures.
TL;DR: The results show strong DNA protective effects of the substances tested in accordance with epidemiological studies linking a diet rich in antioxidative micronutrients with a lowered risk for cancer development.
Journal ArticleDOI
The role of γ‐glutamyl transpeptidase in the biosynthesis of glutathione
Avishay-Abraham Stark,Noga Porat,Gloria Volohonsky,Gloria Volohonsky,Arthur Komlosh,Evgenia Bluvshtein,Chen Tubi,Pablo Steinberg +7 more
TL;DR: Avishay-Abraham Stark, Noga Porat, Gloria Volohonsky, Arthur Komlosh, Evgenia Bluvshtein, Chen Tubi and Pablo Steinberg a Department of Biochemistry, Tel Aviv University, Ramat Aviv 69978, Israel bPresent address: Department of Molecular Genetics, Weizmann Institute, Rehovot 76100, Israel cInstitute fur Ernahrungtoxikologie, Universitat Potsdam, Atrhur Scheunert-Allee 114-116, D14588
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The metabolic basis of inherited disease
TL;DR: The metabolic basis of inherited disease, the metabolic basis for inherited disease as mentioned in this paper, The metabolic basis in inherited disease and inherited diseases, and inherited disease diagnosis and management, in the context of inherited diseases
Journal ArticleDOI
Antioxidant and Redox Regulation of Gene Transcription
Chandan K. Sen,Lester Packer +1 more
TL;DR: The efficacy of different antioxidants to favorably influence the molecular mechanisms implicated in human disease should be a critical determinant of its selection for clinical studies.
Journal ArticleDOI
Efficacy of oral N-acetylcysteine in the treatment of acetaminophen overdose. Analysis of the national multicenter study (1976 to 1985)
TL;DR: It is concluded that N-acetylcysteine treatment should be started within eight hours of an acetaminophen overdose, but that treatment is still indicated at least as late as 24 hours after ingestion, and it may be superior when treatment is delayed.