Journal ArticleDOI
Biologic and pharmacologic regulation of mammalian glutathione synthesis.
TLDR
Because GSH plays a critical role in cellular defenses against electrophiles, oxidative stress and nitrosating species, pharmacologic manipulation of GSH synthesis has received much attention.About:
This article is published in Free Radical Biology and Medicine.The article was published on 1999-11-01. It has received 1120 citations till now. The article focuses on the topics: Glutathione & Buthionine sulfoximine.read more
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The x(c)- cystine/glutamate antiporter: a potential target for therapy of cancer and other diseases.
TL;DR: This review focuses on the expression and function of the x c− transporter in cells and tissues with particular emphasis on its role in disease pathogenesis and the potential use ofx ”c− inhibitors for arresting tumor growth and/or sensitizing cancers.
Journal ArticleDOI
Glutathione Metabolism and Parkinson’s Disease
TL;DR: The synthesis, metabolism, and functional interactions of glutathione are examined and how these relate to the protection of dopaminergic neurons from oxidative damage and its therapeutic potential in Parkinson disease are discussed.
Journal ArticleDOI
Structure, function, and post-translational regulation of the catalytic and modifier subunits of glutamate cysteine ligase
Christopher C. Franklin,Donald S. Backos,Isaac Mohar,Charles L. White,Henry Jay Forman,Terrance J. Kavanagh +5 more
TL;DR: Variability in GCL expression is associated with several disease phenotypes and transgenic mouse and rat models promise to be highly useful for investigating the relationships between GCL activity, GSH synthesis, and disease in humans.
Journal ArticleDOI
High oxidative damage levels in the longest-living rodent, the naked mole-rat
Blazej Andziak,Timothy O'Connor,Wenbo Qi,Eric DeWaal,Anson Pierce,Asish R. Chaudhuri,Asish R. Chaudhuri,Holly Van Remmen,Rochelle Buffenstein +8 more
TL;DR: The findings strongly suggest that mechanisms other than attenuated oxidative stress explain the impressive longevity of the naked mole‐rat and that NMRs live an order of magnitude longer than predicted based on their body size.
Journal ArticleDOI
Layer‐By‐Layer‐Assembled Capsules and Films for Therapeutic Delivery
TL;DR: This review highlights important and recent studies that advance the use of LbL-assembled materials as therapeutic devices and seeks to identify areas that require additional investigation for future development of the field.
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The metabolic basis of inherited disease
TL;DR: The metabolic basis of inherited disease, the metabolic basis for inherited disease as mentioned in this paper, The metabolic basis in inherited disease and inherited diseases, and inherited disease diagnosis and management, in the context of inherited diseases
Journal ArticleDOI
Antioxidant and Redox Regulation of Gene Transcription
Chandan K. Sen,Lester Packer +1 more
TL;DR: The efficacy of different antioxidants to favorably influence the molecular mechanisms implicated in human disease should be a critical determinant of its selection for clinical studies.
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Efficacy of oral N-acetylcysteine in the treatment of acetaminophen overdose. Analysis of the national multicenter study (1976 to 1985)
TL;DR: It is concluded that N-acetylcysteine treatment should be started within eight hours of an acetaminophen overdose, but that treatment is still indicated at least as late as 24 hours after ingestion, and it may be superior when treatment is delayed.