Journal ArticleDOI
Biologic and pharmacologic regulation of mammalian glutathione synthesis.
TLDR
Because GSH plays a critical role in cellular defenses against electrophiles, oxidative stress and nitrosating species, pharmacologic manipulation of GSH synthesis has received much attention.About:
This article is published in Free Radical Biology and Medicine.The article was published on 1999-11-01. It has received 1120 citations till now. The article focuses on the topics: Glutathione & Buthionine sulfoximine.read more
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cDNA cloning and expression analysis of the catalytic subunit of glutamate cysteine ligase gene in an annelid polychaete after cadmium exposure: A potential tool for pollution biomonitoring
Juliana Zomer Sandrini,Juliana Zomer Sandrini,Jomar Pereira Laurino,Terumi Hatanaka,José Maria Monserrat,José Maria Monserrat,Luis Fernando Marins,Luis Fernando Marins +7 more
TL;DR: The present study reports, for the first time, the cDNA sequence for the GCLC in an annelid species, the polychaete Laeonereis acuta (Nereididae), and deduced amino acid sequence showed homology with other animal species, and was used to infer a phylogenetic tree with G CLC amino acid sequences from other taxonomic groups.
Journal ArticleDOI
Pyrrolidine dithiocarbamate augments Hg2+-mediated induction of macrophage cell death via oxidative stress-induced apoptosis and necrosis signaling pathways
TL;DR: The results suggest that Hg(2+)/PDTC complex-induced oxidative stress causes macrophage cell death via both apoptosis and necrosis and imply for the first time that PDTC dramatically increases the uptake and toxicological effects of HG(2+) instead of detoxification.
Journal ArticleDOI
α-Lipoic acid protects against the oxidative stress and cytotoxicity induced by cadmium in HepG2 cells through regenerating glutathione regulated by glutamate-cysteine ligase.
TL;DR: It is indicated that α-LA is an effective agent to reduce the oxidative stress and cytotoxicity induced by cadmium by regenerating GSH levels through increasing the activities and the expressions of γ-GCL.
Journal ArticleDOI
Amoxicillin Inactivation by Thiol-Catalyzed Cyclization Reduces Protein Haptenation and Antibacterial Potency.
María A. Pajares,Tahl Zimmerman,Francisco J. Sánchez-Gómez,Adriana Ariza,María José Torres,Miguel Blanca,Francisco Javier Cañada,Maria I. Montañez,Dolores Pérez-Sala +8 more
TL;DR: It is shown that several thiol-containing compounds, including dithiothreitol, N-acetyl-L-cysteine, and glutathione, perform a nucleophilic attack on the amoxicillin molecule that is followed by an internal rearrangement leading to am toxicillin diketopiperazine, a knownAmoxicillin metabolite with residual activity.
Journal ArticleDOI
The protective effects of vitamin E against selenium-induced oxidative damage and hepatotoxicity in rats
TL;DR: It is demonstrated that vitamin E supplementation provides an effective protection against oxidative damage and hepatotoxicity induced by selenosis, and counteracted the hepatic histopathological changes.
References
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The metabolic basis of inherited disease
TL;DR: The metabolic basis of inherited disease, the metabolic basis for inherited disease as mentioned in this paper, The metabolic basis in inherited disease and inherited diseases, and inherited disease diagnosis and management, in the context of inherited diseases
Journal ArticleDOI
Antioxidant and Redox Regulation of Gene Transcription
Chandan K. Sen,Lester Packer +1 more
TL;DR: The efficacy of different antioxidants to favorably influence the molecular mechanisms implicated in human disease should be a critical determinant of its selection for clinical studies.
Journal ArticleDOI
Efficacy of oral N-acetylcysteine in the treatment of acetaminophen overdose. Analysis of the national multicenter study (1976 to 1985)
TL;DR: It is concluded that N-acetylcysteine treatment should be started within eight hours of an acetaminophen overdose, but that treatment is still indicated at least as late as 24 hours after ingestion, and it may be superior when treatment is delayed.