Journal ArticleDOI
Biologic and pharmacologic regulation of mammalian glutathione synthesis.
TLDR
Because GSH plays a critical role in cellular defenses against electrophiles, oxidative stress and nitrosating species, pharmacologic manipulation of GSH synthesis has received much attention.About:
This article is published in Free Radical Biology and Medicine.The article was published on 1999-11-01. It has received 1120 citations till now. The article focuses on the topics: Glutathione & Buthionine sulfoximine.read more
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Universidade federal de santa catarina centro de ciências biológicas programa de pós-graduação em neurociências papel do zinco no sistema nervoso central: defesas antioxidantes e sinalização celular via pi3k/akt
TL;DR: Investigation of the effects of zinc in vitro on antioxidant defense systems, on cell viability, and on modulation of PI3K/AKT pathway in hippocampal slices of young rats showed that ZnCl2 in the highest concentrations tested, decreased cell viability of hippocampusal slices, suggesting a specific in vitro effect of zinc upon GR.
Journal ArticleDOI
Schisandrin B Enhances Glutathione Redox Cycling and Protects Against β-amyloid-induced Apoptosis in Human Neuroblastoma SH-SY5Y Cells: A Comparative Study of Various Phytochemicals
TL;DR: ()Sch B may enhance cellular glutathione redox cycling, presumably by increasing G6PDH and GR activities, via activation of the Nrf2 signaling pathway, whereas EGCG likely acts as a radical scavenger.
Journal ArticleDOI
NIPSNAP1 deficient mice exhibit altered liver amino acid, lipid and nucleotide metabolism
TL;DR: The results suggest that NIPSNAP1 deficiency affects multiple processes in intermediate metabolism and results in oxidative stress in the liver.
Journal ArticleDOI
Engineered Bacterially Expressed Polypeptides: Assembly into Polymer Particles with Tailored Degradation Profiles
TL;DR: It is demonstrated how control over the positioning of functional groups can be used to tune the degradation of assembled polypeptide particles.
Dissertation
Étude des systèmes de défenses antitoxiques chez l'amphipode Gammarus roeseli : effets du parasitisme et d'une exposition au cadmium
TL;DR: Dans ce contexte, nous avons choisi d'etudier l'influence d'un parasite acanthocephale, Polymorphus minutus, transmis horizontalement et de microsporidies a transmission verticale, sur les reponses physiologiques de leur hote, Gammarus roeseli, un crustace amphipode d'eau douce d'interet ecotoxicologique.
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Book
The metabolic basis of inherited disease
TL;DR: The metabolic basis of inherited disease, the metabolic basis for inherited disease as mentioned in this paper, The metabolic basis in inherited disease and inherited diseases, and inherited disease diagnosis and management, in the context of inherited diseases
Journal ArticleDOI
Antioxidant and Redox Regulation of Gene Transcription
Chandan K. Sen,Lester Packer +1 more
TL;DR: The efficacy of different antioxidants to favorably influence the molecular mechanisms implicated in human disease should be a critical determinant of its selection for clinical studies.
Journal ArticleDOI
Efficacy of oral N-acetylcysteine in the treatment of acetaminophen overdose. Analysis of the national multicenter study (1976 to 1985)
TL;DR: It is concluded that N-acetylcysteine treatment should be started within eight hours of an acetaminophen overdose, but that treatment is still indicated at least as late as 24 hours after ingestion, and it may be superior when treatment is delayed.