Journal ArticleDOI
Biologic and pharmacologic regulation of mammalian glutathione synthesis.
TLDR
Because GSH plays a critical role in cellular defenses against electrophiles, oxidative stress and nitrosating species, pharmacologic manipulation of GSH synthesis has received much attention.About:
This article is published in Free Radical Biology and Medicine.The article was published on 1999-11-01. It has received 1120 citations till now. The article focuses on the topics: Glutathione & Buthionine sulfoximine.read more
Citations
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Journal ArticleDOI
Developmental Potential of Prepubertal Mouse Oocytes Is Compromised Due Mainly to Their Impaired Synthesis of Glutathione
Guang-Zhong Jiao,Xinyan Cao,Wei Cui,Hua-Yu Lian,Yi-Long Miao,Xiu-Fen Wu,Dong Han,Jing-He Tan +7 more
TL;DR: Results have confirmed the hypothesis that prepubertal oocytes have a decreased ability to synthesize glutathione leading to an impaired potential to reduce ROS and to form male pronuclei and blastocysts, and damages the microfilament network, which affects cortical granule redistribution leading to polyspermy.
Journal ArticleDOI
Influence of resveratrol on oxidative damage in genomic DNA and apoptosis induced by cisplatin.
TL;DR: Evidence for the first time is provided that resveratrol has a protective role in the abatement of cisplatin-induced genotoxicity and apoptosis in somatic and germinal cells of mice.
Journal ArticleDOI
Exploring the role of polymer structure on intracellular nucleic acid delivery via polymeric nanoparticles.
TL;DR: The polymer structural features that enable effective intracellular delivery of DNA and RNA, including protection of nucleic acid cargo, cellular uptake, endosomal escape, vector unpacking, and delivery to the intrACEllular site of activity are discussed.
Journal ArticleDOI
An integrated functional genomic study of acute phenobarbital exposure in the rat
Claire L. Waterman,Richard A. Currie,Lisa Cottrell,Jacky Dow,Jayne Wright,Catherine J. Waterfield,Julian L. Griffin +6 more
TL;DR: The data fusion of metabolomic and transcriptomic changes proved to be a highly sensitive approach for monitoring early stage changes in altered hepatic metabolism, oxidative stress and cytochrome P450 induction simultaneously.
Journal ArticleDOI
Mercury (II) alters mitochondrial activity of monocytes at sublethal doses via oxidative stress mechanisms.
Regina L. W. Messer,Petra E. Lockwood,Wan Y. Tseng,Kerry Edwards,Melissa Shaw,Gretchen B. Caughman,Jill B. Lewis,John C. Wataha +7 more
TL;DR: In this article, the authors tested the hypothesis that concentrations of Hg(II) of 10 to 300 nM alter monocyte activity via a redox-dependent mechanism and found that 20 microm Hg (II) inhibited monocytic mitochondrial activity by 50%.
References
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Book
The metabolic basis of inherited disease
TL;DR: The metabolic basis of inherited disease, the metabolic basis for inherited disease as mentioned in this paper, The metabolic basis in inherited disease and inherited diseases, and inherited disease diagnosis and management, in the context of inherited diseases
Journal ArticleDOI
Antioxidant and Redox Regulation of Gene Transcription
Chandan K. Sen,Lester Packer +1 more
TL;DR: The efficacy of different antioxidants to favorably influence the molecular mechanisms implicated in human disease should be a critical determinant of its selection for clinical studies.
Journal ArticleDOI
Efficacy of oral N-acetylcysteine in the treatment of acetaminophen overdose. Analysis of the national multicenter study (1976 to 1985)
TL;DR: It is concluded that N-acetylcysteine treatment should be started within eight hours of an acetaminophen overdose, but that treatment is still indicated at least as late as 24 hours after ingestion, and it may be superior when treatment is delayed.