Journal ArticleDOI
Biologic and pharmacologic regulation of mammalian glutathione synthesis.
TLDR
Because GSH plays a critical role in cellular defenses against electrophiles, oxidative stress and nitrosating species, pharmacologic manipulation of GSH synthesis has received much attention.About:
This article is published in Free Radical Biology and Medicine.The article was published on 1999-11-01. It has received 1120 citations till now. The article focuses on the topics: Glutathione & Buthionine sulfoximine.read more
Citations
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Journal ArticleDOI
Regulation of GCL activity and cellular glutathione through inhibition of ERK phosphorylation
TL;DR: The findings in the present study suggest that inhibition of B‐Raf/MEK/ERK pathway might be a promising physiological approach to up‐regulate GCL activity and GSH.
Journal ArticleDOI
BJSM reviews: A to Z of nutritional supplements: dietary supplements, sports nutrition foods and ergogenic aids for health and performance—Part 18
TL;DR: Part 18 extends the general amino acids overview in Part 2, by reviewing specifically glutamine and glutamate, and the tripeptide antioxidant, glutathione, and its roles in metabolic, signalling and transcriptional processes.
Journal ArticleDOI
Taurine treatment prevents derangement of the hepatic γ-glutamyl cycle and methylglyoxal metabolism in a mouse model of classical homocystinuria: regulatory crosstalk between thiol and sulfinic acid metabolism.
Kenneth N. Maclean,Hua Jiang,Stefanos Aivazidis,Eugene Kim,Colin T. Shearn,Peter Harris,Dennis R. Petersen,Robert H. Allen,Sally P. Stabler,James R. Roede +9 more
TL;DR: Taurine treatment prevents derangement of the hepatic γ‐glutamyl cycle and methylglyoxal metabolism in a mouse model of classical homocystinuria and indicates that taurine has significant therapeutic potential for both HCU and other diseases for which GSH depletion is a critical pathogenic factor.
Journal ArticleDOI
Selenium toxicosis assessment (in vivo and in vitro) and the protective role of vitamin B12 in male quail (Coturnix Coturnix).
M.A. Gad,S.M. Abd El-Twab +1 more
TL;DR: Results suggest that selenosis can be reduced by vitamin B12 supplementation and in vitro study using isolated quail hepatocytes incubated with sodium selenite showed a dose-dependent response for toxicity markers.
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The antioxidant glutathione protects against enteric neuron death in situ, but its depletion is protective during colitis
TL;DR: Results show that both enteric glia and neurons express the cellular machinery necessary for glutathione (GSH) synthesis and that glial GSH synthesis is necessary for neuronal survival in isolated enteric nervous system (ENS) preparations.
References
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The metabolic basis of inherited disease
TL;DR: The metabolic basis of inherited disease, the metabolic basis for inherited disease as mentioned in this paper, The metabolic basis in inherited disease and inherited diseases, and inherited disease diagnosis and management, in the context of inherited diseases
Journal ArticleDOI
Antioxidant and Redox Regulation of Gene Transcription
Chandan K. Sen,Lester Packer +1 more
TL;DR: The efficacy of different antioxidants to favorably influence the molecular mechanisms implicated in human disease should be a critical determinant of its selection for clinical studies.
Journal ArticleDOI
Efficacy of oral N-acetylcysteine in the treatment of acetaminophen overdose. Analysis of the national multicenter study (1976 to 1985)
TL;DR: It is concluded that N-acetylcysteine treatment should be started within eight hours of an acetaminophen overdose, but that treatment is still indicated at least as late as 24 hours after ingestion, and it may be superior when treatment is delayed.