Journal ArticleDOI
Biologic and pharmacologic regulation of mammalian glutathione synthesis.
TLDR
Because GSH plays a critical role in cellular defenses against electrophiles, oxidative stress and nitrosating species, pharmacologic manipulation of GSH synthesis has received much attention.About:
This article is published in Free Radical Biology and Medicine.The article was published on 1999-11-01. It has received 1120 citations till now. The article focuses on the topics: Glutathione & Buthionine sulfoximine.read more
Citations
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Journal ArticleDOI
Redox regulation of ion channels in the pulmonary circulation.
TL;DR: Further investigation of the interaction between redox status and ion channel gating could result in a better understanding of the physiological and pathophysiological importance of these mediators in general and the implications of such modifications in cellular functions and related diseases and their importance for targeted treatment strategies.
Journal ArticleDOI
Glutathione synthesis is compromised in erythrocytes from individuals with HIV.
Devin Morris,Judy Ly,Po-Ting Chi,John Daliva,Truongson Nguyen,Charleen Soofer,Yung C. Chen,Minette Lagman,Vishwanath Venketaraman +8 more
TL;DR: The data supports the hypothesis that compromised levels of GSH in HIV infected individuals’ is due to decreased levels ofGSH-synthetic enzymes and indicates the benefit of an antioxidant supplement which can reduce the cellular damage and promote the functions of immune cells.
Journal ArticleDOI
Glutathione-Mediated Detoxification of Halobenzoquinone Drinking Water Disinfection Byproducts in T24 Cells
TL;DR: The mass spectrometry study confirms that HBQs can conjugate with GSH, explaining in part the mechanism of GSH depletion byHBQs, and Pearson correlation analysis shows that the cellular GSH level is inversely correlated with ROS production and cellular GST activity in HBQ-treated cells.
Journal ArticleDOI
Glutathione in Cerebral Microvascular Endothelial Biology and Pathobiology: Implications for Brain Homeostasis
TL;DR: This paper highlights the current insights and hypotheses into the role of GSH in cerebral microvascular biology and pathobiology with special focus on endothelial GSH and vascular integrity, oxidative disruption of endothelial barrier function, GSH regulation of endothelium cell proliferation, and the pathological implications of G SH disruption in oxidative stress-associated neurovascular disorders, such as diabetes and stroke.
Journal ArticleDOI
Neuronal Glutathione Content and Antioxidant Capacity can be Normalized In Situ by N-acetyl Cysteine Concentrations Attained in Human Cerebrospinal Fluid
Reno C. Reyes,Reno C. Reyes,Giordano Fabricio Cittolin-Santos,Ji-Eun Kim,Ji-Eun Kim,Seok Joon Won,Seok Joon Won,Angela M. Brennan-Minnella,Angela M. Brennan-Minnella,Maya Katz,Maya Katz,Graham A. Glass,Graham A. Glass,Raymond A. Swanson,Raymond A. Swanson +14 more
TL;DR: An approach in which mice are used to establish the levels of NAC in cerebrospinal fluid (CSF) required to affect brain neurons and oral NAC administration to humans produced CSF concentrations of up to 10 μM, demonstrating that oral Nac administration can surpass the levels required for biological activity in brain.
References
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The metabolic basis of inherited disease
TL;DR: The metabolic basis of inherited disease, the metabolic basis for inherited disease as mentioned in this paper, The metabolic basis in inherited disease and inherited diseases, and inherited disease diagnosis and management, in the context of inherited diseases
Journal ArticleDOI
Antioxidant and Redox Regulation of Gene Transcription
Chandan K. Sen,Lester Packer +1 more
TL;DR: The efficacy of different antioxidants to favorably influence the molecular mechanisms implicated in human disease should be a critical determinant of its selection for clinical studies.
Journal ArticleDOI
Efficacy of oral N-acetylcysteine in the treatment of acetaminophen overdose. Analysis of the national multicenter study (1976 to 1985)
TL;DR: It is concluded that N-acetylcysteine treatment should be started within eight hours of an acetaminophen overdose, but that treatment is still indicated at least as late as 24 hours after ingestion, and it may be superior when treatment is delayed.