Journal ArticleDOI
Biologic and pharmacologic regulation of mammalian glutathione synthesis.
TLDR
Because GSH plays a critical role in cellular defenses against electrophiles, oxidative stress and nitrosating species, pharmacologic manipulation of GSH synthesis has received much attention.About:
This article is published in Free Radical Biology and Medicine.The article was published on 1999-11-01. It has received 1120 citations till now. The article focuses on the topics: Glutathione & Buthionine sulfoximine.read more
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Hydrolytically and Reductively Degradable High-Molecular-Weight Poly(ethylene glycol)s
TL;DR: Reductively degradable multiblock polymers for gene and drug delivery were synthesised by oxidative polycondensation of poly(ethylene glycol)-cysteine derivatives containing ester or urethane bonds by studying hydrolysis rate of polymer esters and reduction with glutathione and dithiothreitol.
Journal ArticleDOI
Roles of intracellular and extracellular ROS formation in apoptosis induced by cold atmospheric helium plasma and X-irradiation in the presence of sulfasalazine
Rohan Moniruzzaman,Mati Ur Rehman,Qing-Li Zhao,Paras Jawaid,Yohei Mitsuhashi,Shuichi Imaue,Kumiko Fujiwara,Ryohei Ogawa,Kei Tomihara,Jun-ichi Saitoh,Kyo Noguchi,Takashi Kondo,Makoto Noguchi +12 more
TL;DR: The results suggest that IR‐induced apoptosis is due to specific and effective ROS distribution since intracellular ROS formation is marginal and the high production of ROS inside and outside of cells plays unique roles in He‐CAP induced apoptosis.
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Ginsenoside Rb1 Blocks Ritonavir-Induced Oxidative Stress and eNOS Downregulation through Activation of Estrogen Receptor-Beta and Upregulation of SOD in Human Endothelial Cells
TL;DR: This study explored a mechanism by which ginsenoside Rb1 could protect endothelial cells via binding of estrogen receptors (ERs) and found that several human endothelial cell lines differentially expressed ER-β and had very low levels of ER-α.
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Combined effects of coenzyme Q10 and Vitamin E in cadmium induced alterations of antioxidant defense system in the rat heart
Branka I. Ognjanović,Snežana D. Marković,Sladjan Z. Pavlović,Radoslav V. Žikić,Andraš Š. Štajn,Zorica S. Saičić +5 more
TL;DR: The obtained results support the assumption that CoQ(10) and Vit E functions cooperatively with endogenous antioxidants and diminished toxic effects of Cd in rat heart.
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Do male and female gammarids defend themselves differently during chemical stress
TL;DR: The influence of gender on the detoxification response, energy reserves, and biomarker of toxic effects in Gammarus roeseli exposed to cadmium supports the importance of taking into account the gender in ecotoxicological studies to have an overview of xenobiotics effects on a population.
References
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The metabolic basis of inherited disease
TL;DR: The metabolic basis of inherited disease, the metabolic basis for inherited disease as mentioned in this paper, The metabolic basis in inherited disease and inherited diseases, and inherited disease diagnosis and management, in the context of inherited diseases
Journal ArticleDOI
Antioxidant and Redox Regulation of Gene Transcription
Chandan K. Sen,Lester Packer +1 more
TL;DR: The efficacy of different antioxidants to favorably influence the molecular mechanisms implicated in human disease should be a critical determinant of its selection for clinical studies.
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Efficacy of oral N-acetylcysteine in the treatment of acetaminophen overdose. Analysis of the national multicenter study (1976 to 1985)
TL;DR: It is concluded that N-acetylcysteine treatment should be started within eight hours of an acetaminophen overdose, but that treatment is still indicated at least as late as 24 hours after ingestion, and it may be superior when treatment is delayed.