Journal ArticleDOI
Biologic and pharmacologic regulation of mammalian glutathione synthesis.
TLDR
Because GSH plays a critical role in cellular defenses against electrophiles, oxidative stress and nitrosating species, pharmacologic manipulation of GSH synthesis has received much attention.About:
This article is published in Free Radical Biology and Medicine.The article was published on 1999-11-01. It has received 1120 citations till now. The article focuses on the topics: Glutathione & Buthionine sulfoximine.read more
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Chloroform, carbon tetrachloride and glutathione depletion induce secondary genotoxicity in liver cells via oxidative stress
TL;DR: It is hypothesised that certain substances, at high concentrations, can induce an oxidative stress via the depletion of glutathione (GSH) and other antioxidant defences and that this may lead to indirect genotoxicity, that could contribute to carcinogenicity.
Journal ArticleDOI
Antioxidant defenses in killifish (Fundulus heteroclitus) exposed to contaminated sediments and model prooxidants: short-term and heritable responses.
TL;DR: Larval first- and second-generation offspring of Elizabeth River killifish were more resistant to the toxicity of t-butyl hydroperoxide than were King's Creek offspring, indicating a heritable tolerance of exposure to oxidative stress.
Journal ArticleDOI
Emerging promise of sulforaphane-mediated Nrf2 signaling cascade against neurological disorders
Md. Sahab Uddin,Abdullah Al Mamun,Md. Jakaria,S. Thangapandiyan,Jamil Ahmad,Md. Ataur Rahman,Bijo Mathew,Mohamed M. Abdel-Daim,Mohamed M. Abdel-Daim,Lotfi Aleya +9 more
TL;DR: Current studies of sulforaphane-mediated Nrf2 activation in the treatment of various neurological disorders are recapitulate, which shows potential in regulating the series of cytoprotective enzyme expressions that have neuroprotective, antioxidative, and detoxification actions.
Journal ArticleDOI
Molecular mechanisms of cisplatin resistance in bladder cancer.
Ross M. Drayton,James W.F. Catto +1 more
TL;DR: These include methods to reduce cisplatin bioavailability within a cell, and defects in the machinery that produces cell death following cisPlatin-induced DNA damage, which could be used to predict response in individual tumors.
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Redox regulation and its emerging roles in stem cells and stem-like cancer cells.
Marcia A. Ogasawara,Hui Zhang +1 more
TL;DR: Evidence that supports the involvement of redox homeostasis for stem cell self-renewal, differentiation, and survival are reviewed and the possibility of exploiting the redox status in cancer stem cells as a novel therapeutic strategy is discussed.
References
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The metabolic basis of inherited disease
TL;DR: The metabolic basis of inherited disease, the metabolic basis for inherited disease as mentioned in this paper, The metabolic basis in inherited disease and inherited diseases, and inherited disease diagnosis and management, in the context of inherited diseases
Journal ArticleDOI
Antioxidant and Redox Regulation of Gene Transcription
Chandan K. Sen,Lester Packer +1 more
TL;DR: The efficacy of different antioxidants to favorably influence the molecular mechanisms implicated in human disease should be a critical determinant of its selection for clinical studies.
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Efficacy of oral N-acetylcysteine in the treatment of acetaminophen overdose. Analysis of the national multicenter study (1976 to 1985)
TL;DR: It is concluded that N-acetylcysteine treatment should be started within eight hours of an acetaminophen overdose, but that treatment is still indicated at least as late as 24 hours after ingestion, and it may be superior when treatment is delayed.