Journal ArticleDOI
Biologic and pharmacologic regulation of mammalian glutathione synthesis.
TLDR
Because GSH plays a critical role in cellular defenses against electrophiles, oxidative stress and nitrosating species, pharmacologic manipulation of GSH synthesis has received much attention.About:
This article is published in Free Radical Biology and Medicine.The article was published on 1999-11-01. It has received 1120 citations till now. The article focuses on the topics: Glutathione & Buthionine sulfoximine.read more
Citations
More filters
Journal ArticleDOI
Interactions between endogenous and dietary antioxidants against Pb-induced oxidative stress in wild ungulates from a Pb polluted mining area
TL;DR: Pb exposure in deer was associated with lower GSH, α-tocopherol and retinyl esters, and higher free retinol and TBARS, and a similar effect on vitamin A balance was observed in wild boar, but this was accompanied with an increase in GSH and α-ocopherol.
Journal ArticleDOI
N-Acetylcysteine Prevents Hypertension via Regulation of the ADMA-DDAH Pathway in Young Spontaneously Hypertensive Rats
TL;DR: The observed antihypertensive effects of NAC in young SHR might be due to restoration of DDAH activity to reduce ADMA, leading to attenuation of oxidative stress, and highlight the impact of Nac on the development of hypertension by regulating ADMA-DDAH pathway.
Journal ArticleDOI
Effects of N-acetylcysteine on oxidative responses in the liver of fenthion exposed Cyprinus carpio
TL;DR: Fenthion had a significant oxidative stress inducing potential through the reduction of glutathione redox capacity and the critical point for overcoming oxidative stress by N-acetylcysteine in fenthion toxicity was the selection of the dose.
Journal ArticleDOI
Hepatoprotective Effect of Polysaccharides Isolated from Dendrobium officinale against Acetaminophen-Induced Liver Injury in Mice via Regulation of the Nrf2-Keap1 Signaling Pathway
Guosheng Lin,Dandan Luo,Jingjing Liu,Xiao-Li Wu,Jin-Fen Chen,Qiong-Hui Huang,Ling-Ye Su,Lei Zeng,Hongfeng Wang,Zi-Ren Su +9 more
TL;DR: It is revealed that DOP treatment exerted potentially hepatoprotective effects against APAP-induced liver injury by suppressing the oxidative stress and activating the Nrf2−Keap1 signaling pathway.
Journal ArticleDOI
L-cysteine efflux in erythrocytes as a function of human age: correlation with reduced glutathione and total anti-oxidant potential.
TL;DR: A significant (p<0.0001) decline in the efflux of L-cysteine in erythrocytes during human aging, and the GSH/GSSG ratio decreases as a function of human age, correlates with the decrease in GSH and the FRAP value.
References
More filters
Book
The metabolic basis of inherited disease
TL;DR: The metabolic basis of inherited disease, the metabolic basis for inherited disease as mentioned in this paper, The metabolic basis in inherited disease and inherited diseases, and inherited disease diagnosis and management, in the context of inherited diseases
Journal ArticleDOI
Antioxidant and Redox Regulation of Gene Transcription
Chandan K. Sen,Lester Packer +1 more
TL;DR: The efficacy of different antioxidants to favorably influence the molecular mechanisms implicated in human disease should be a critical determinant of its selection for clinical studies.
Journal ArticleDOI
Efficacy of oral N-acetylcysteine in the treatment of acetaminophen overdose. Analysis of the national multicenter study (1976 to 1985)
TL;DR: It is concluded that N-acetylcysteine treatment should be started within eight hours of an acetaminophen overdose, but that treatment is still indicated at least as late as 24 hours after ingestion, and it may be superior when treatment is delayed.