Journal ArticleDOI
Biologic and pharmacologic regulation of mammalian glutathione synthesis.
TLDR
Because GSH plays a critical role in cellular defenses against electrophiles, oxidative stress and nitrosating species, pharmacologic manipulation of GSH synthesis has received much attention.About:
This article is published in Free Radical Biology and Medicine.The article was published on 1999-11-01. It has received 1120 citations till now. The article focuses on the topics: Glutathione & Buthionine sulfoximine.read more
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The involvement of Nrf2 antioxidant signalling pathway in the protection of monocrotaline-induced hepatic sinusoidal obstruction syndrome in rats by (+)-catechin hydrate.
TL;DR: The critical involvement of Nrf2 antioxidant signalling pathway in CAT-provided the protection against MCT-induced HSOS is demonstrated.
Journal ArticleDOI
The cysteine releasing pattern of some antioxidant thiazolidine-4-carboxylic acids.
F Esra Önen Bayram,Hande Sipahi,Ebru Türköz Acar,Reyhan Kahveci Ulugöl,Kerem Buran,Hülya Akgün +5 more
TL;DR: Thiazolidine-4-carboxylic acids were synthesized and evaluated for their antioxidant properties via the DDPH and CUPRAC assays and the cysteine releasing capacity of the obtained compounds was investigated in aqueous and organic medium in order to correlate the relevant antioxidant properties of the molecules with their cysteINE releasing pattern.
Journal ArticleDOI
Regulation of the ovarian oxidative status by leptin during the ovulatory process in rats.
María Guillermina Bilbao,María Paula Di Yorio,Rocío Alejandra Galarza,Cecilia Laura Varone,Alicia Graciela Faletti +4 more
TL;DR: Leptin can modulate the oxidative status of the ovarian tissue, during the ovulatory process, by acting on different targets according to its circulating levels, as well as playing a protective role against the oxidative stress.
Journal ArticleDOI
Ferroptosis and Autoimmune Diseases
TL;DR: This review addresses how ferroptosis is initiated and how it contributes to the pathogenesis of autoimmune diseases, including systemic lupus erythematosus, rheumatoid arthritis, and inflammatory bowel diseases.
Book
Oxidants in biology: a question of balance
Henry Jay Forman,R. Kohen,M. Portugal,A. van der Vliet,Milena Hristova,S. Mc Carthy,David I. Kasahara,P. S. Ljubuncic,M. Bar Shai,Abraham Z. Reznick,Lukáš Kubala,Antonín Lojek,Karel Souček,Jiřina Hofmanová,Alena Vaculová,A. Kozubik,Velio Bocci,Lucia Ciccoli,Silvia Leoncini,Cinzia Signorini,Mario Comporti,Kristy M. Powers,Larry W. Oberley,Frederick E. Domann,F. Cimino,A. Saija,Tzipora Goldkorn,Elaine M. Khan,Elisabetta Damiani,Paola Astolfi,Patricia Carloni,P. Stipa,Lucedio Greci,R. Harper,Elisa Pagnin,A. Avogaro,L. A. Calò,I. Irminger Finger,S. Pervais,F. Natella,A. Ramberti,C. Scaccini,Concetta Gardi,Beatrice Arezzini,Daniela Vecchio,Monaco B,Giuseppe Valacchi,Pa Davis +47 more
TL;DR: The role of BRCA1-associated protein BARD1 in oxidative stress response and signaling and proliferation control and the role of DUOX isozymes in the respiratory tract epithelium are studied.
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The metabolic basis of inherited disease
TL;DR: The metabolic basis of inherited disease, the metabolic basis for inherited disease as mentioned in this paper, The metabolic basis in inherited disease and inherited diseases, and inherited disease diagnosis and management, in the context of inherited diseases
Journal ArticleDOI
Antioxidant and Redox Regulation of Gene Transcription
Chandan K. Sen,Lester Packer +1 more
TL;DR: The efficacy of different antioxidants to favorably influence the molecular mechanisms implicated in human disease should be a critical determinant of its selection for clinical studies.
Journal ArticleDOI
Efficacy of oral N-acetylcysteine in the treatment of acetaminophen overdose. Analysis of the national multicenter study (1976 to 1985)
TL;DR: It is concluded that N-acetylcysteine treatment should be started within eight hours of an acetaminophen overdose, but that treatment is still indicated at least as late as 24 hours after ingestion, and it may be superior when treatment is delayed.