Journal ArticleDOI
Biologic and pharmacologic regulation of mammalian glutathione synthesis.
TLDR
Because GSH plays a critical role in cellular defenses against electrophiles, oxidative stress and nitrosating species, pharmacologic manipulation of GSH synthesis has received much attention.About:
This article is published in Free Radical Biology and Medicine.The article was published on 1999-11-01. It has received 1120 citations till now. The article focuses on the topics: Glutathione & Buthionine sulfoximine.read more
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Sulodexide and Alzheimer’s Disease: A Preliminary Prospective Study
TL;DR: In the sulodexide group, there was an apparent prevention of cognitive and behavioural impairment compared with acenocoumarol group, and the favourable results may be related to their pharmacodynamic actions of inhibition of PAI-1, which may interfere with the pathogenesis of Alzheimer's disease.
Journal ArticleDOI
Effects of cisplatin on lipid peroxidation and the glutathione redox status in the liver of male rats: The protective role of selenium
Ivana Trbojević,I Branka Ognjanovic,Z Natasa Djordjevic,D Snezana Markovic,Andraš Š. Štajn,P Jelena Gavric,S Zorica Saicic +6 more
TL;DR: It is concluded that selenium functions as a potent antioxidant and suggest that it can control CP-induced hepatotoxicity in rats.
Journal ArticleDOI
Characterizing thiol redox dynamics in the organogenesis stage rat embryo
TL;DR: Thiol redox dynamics, protein synthesis, volumetric growth and net cysteine fluxes over the course of early organogenesis in the rat embryo is characterized and connected, and the yolk sac was found to play a key role in maintaining GSH levels and the GSH: GSSG redox balance in the developing embryo.
Glutathione Dysregulation, Cardiac Oxidative Stress, and Inflammation during n-6 Polyunsaturated Fatty Acid Overload
TL;DR: The structure and function of the heart muscle, and the role of obesity in cardiovascular disease and obesity in Canada, are explained.
Journal ArticleDOI
Myocardial glutathione metabolic status in fat-fed rabbits.
Domenico Lapenna,Giuliano Ciofani,Chiara Cuccurullo,Maria Adele Giamberardino,Franco Cuccurullo +4 more
TL;DR: GSSG-Red- and γ-GT-related decrement of myocardial glutathione content is induced, which, together with GSH-Px dysfunction, may favor tissue oxidative stress and render the myocardium more susceptible to ischemia–reperfusion injury.
References
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The metabolic basis of inherited disease
TL;DR: The metabolic basis of inherited disease, the metabolic basis for inherited disease as mentioned in this paper, The metabolic basis in inherited disease and inherited diseases, and inherited disease diagnosis and management, in the context of inherited diseases
Journal ArticleDOI
Antioxidant and Redox Regulation of Gene Transcription
Chandan K. Sen,Lester Packer +1 more
TL;DR: The efficacy of different antioxidants to favorably influence the molecular mechanisms implicated in human disease should be a critical determinant of its selection for clinical studies.
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Efficacy of oral N-acetylcysteine in the treatment of acetaminophen overdose. Analysis of the national multicenter study (1976 to 1985)
TL;DR: It is concluded that N-acetylcysteine treatment should be started within eight hours of an acetaminophen overdose, but that treatment is still indicated at least as late as 24 hours after ingestion, and it may be superior when treatment is delayed.