Journal ArticleDOI
Biologic and pharmacologic regulation of mammalian glutathione synthesis.
TLDR
Because GSH plays a critical role in cellular defenses against electrophiles, oxidative stress and nitrosating species, pharmacologic manipulation of GSH synthesis has received much attention.About:
This article is published in Free Radical Biology and Medicine.The article was published on 1999-11-01. It has received 1120 citations till now. The article focuses on the topics: Glutathione & Buthionine sulfoximine.read more
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A bioreducible linear poly(β-amino ester) for siRNA delivery
TL;DR: A novel, bioreducible linear poly(β-amino ester) designed to condense siRNA into nanoparticles and efficiently release it upon entering the cytoplasm achieved near-complete knockdown of a fluorescent marker gene in primary human glioblastoma cells with no cytotoxicity.
Journal ArticleDOI
Egg yolk peptides up-regulate glutathione synthesis and antioxidant enzyme activities in a porcine model of intestinal oxidative stress.
TL;DR: Egg yolk peptides prepared from Alcalase and protease N digestion of delipidated egg yolk proteins were found to exhibit antioxidative stress properties and EYP supplementation boosted the systemic antioxidant status in blood by increasing the GSH concentration in red blood cells.
Journal ArticleDOI
Growth hormone alters methionine and glutathione metabolism in Ames dwarf mice
TL;DR: A role for growth hormone in the regulation of antioxidative defense and ultimately, life span in organisms with altered GH or IGF-1 signaling is supported.
Journal ArticleDOI
Dynamic responses of the glutathione system to acute oxidative stress in dystrophic mouse (mdx) muscles.
Roy W. R. Dudley,Maya Khairallah,Shawn R. Mohammed,Larry C. Lands,Christine Des Rosiers,Basil J. Petrof +5 more
TL;DR: The precise mechanisms underlying skeletal muscle damage in Duchenne muscular dystrophy (DMD) remain ill-defined as discussed by the authors, with functional ischemia during muscle activation, with subsequent reperfusion during re-activation.
Journal ArticleDOI
Caffeic acid phenetyl ester accelerates cutaneous wound healing in a rat model and decreases oxidative stress
TL;DR: Cutaneous injury causes a depression in antioxidant status, as reactive oxygen species (ROS) are produced in response to injury.
References
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The metabolic basis of inherited disease
TL;DR: The metabolic basis of inherited disease, the metabolic basis for inherited disease as mentioned in this paper, The metabolic basis in inherited disease and inherited diseases, and inherited disease diagnosis and management, in the context of inherited diseases
Journal ArticleDOI
Antioxidant and Redox Regulation of Gene Transcription
Chandan K. Sen,Lester Packer +1 more
TL;DR: The efficacy of different antioxidants to favorably influence the molecular mechanisms implicated in human disease should be a critical determinant of its selection for clinical studies.
Journal ArticleDOI
Efficacy of oral N-acetylcysteine in the treatment of acetaminophen overdose. Analysis of the national multicenter study (1976 to 1985)
TL;DR: It is concluded that N-acetylcysteine treatment should be started within eight hours of an acetaminophen overdose, but that treatment is still indicated at least as late as 24 hours after ingestion, and it may be superior when treatment is delayed.