Journal ArticleDOI
Biologic and pharmacologic regulation of mammalian glutathione synthesis.
TLDR
Because GSH plays a critical role in cellular defenses against electrophiles, oxidative stress and nitrosating species, pharmacologic manipulation of GSH synthesis has received much attention.About:
This article is published in Free Radical Biology and Medicine.The article was published on 1999-11-01. It has received 1120 citations till now. The article focuses on the topics: Glutathione & Buthionine sulfoximine.read more
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The modifier subunit of Drosophila glutamate-cysteine ligase regulates catalytic activity by covalent and noncovalent interactions and influences glutathione homeostasis in vivo.
TL;DR: It is shown that cysteine residues in the Drosophila melanogaster GCL modifier subunit can form covalent interactions with the catalytic subunit (DmGCLC) and modify its activity and the importance of DmGClM in the regulation of glutathione homeostasis in vivo is demonstrated.
Journal ArticleDOI
Chronic nandrolone administration promotes oxidative stress, induction of pro-inflammatory cytokine and TNF-α mediated apoptosis in the kidneys of CD1 treated mice
Irene Riezzo,Emanuela Turillazzi,Stefania Bello,Santina Cantatore,Daniela Cerretani,Marco Di Paolo,Anna Ida Fiaschi,Paola Frati,Margherita Neri,Monica Pedretti,Vittorio Fineschi +10 more
TL;DR: Dose-related oxidative damage in the kidneys of treated mice is shown by an increase in MDA levels and by a reduction of antioxidant enzyme GR and GPx activities, resulting in the kidney's reduced radical scavenging ability.
Journal ArticleDOI
Melatonin attenuates MPP+-induced neurodegeneration and glutathione impairment in the nigrostriatal dopaminergic pathway.
TL;DR: Results provide direct evidence showing that melatonin attenuates MPP+‐induced nigrostriatal dopaminergic injury by its ability to impede the increase of GSSG/GSH ratio; therefore melatonin may have therapeutic implications in PD.
Journal ArticleDOI
Time-Dependent Modulation of Thioredoxin Reductase Activity Might Contribute to Sulforaphane-Mediated Inhibition of NF-κB Binding to DNA
Elke H. Heiss,Clarissa Gerhäuser +1 more
TL;DR: The chemopreventive agent sulforaphane (SFN) is identified as a novel inhibitor of TrxR enzymatic activity in vitro, highlighting the importance of redox modulation or thiol reactivity for the regulation of NF-kappaB-dependent transcription by SFN.
Journal ArticleDOI
The toxicity of cadmium to three aquatic organisms (Photobacterium phosphoreum, Daphnia magna and Carassius auratus) under different pH levels.
TL;DR: It was found that Cd(2+) was generally more toxic to the three test organisms in alkaline environments than in acidic environments, and D. magna was more sensitive to the toxicity of Cd than P. phosphoreum.
References
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The metabolic basis of inherited disease
TL;DR: The metabolic basis of inherited disease, the metabolic basis for inherited disease as mentioned in this paper, The metabolic basis in inherited disease and inherited diseases, and inherited disease diagnosis and management, in the context of inherited diseases
Journal ArticleDOI
Antioxidant and Redox Regulation of Gene Transcription
Chandan K. Sen,Lester Packer +1 more
TL;DR: The efficacy of different antioxidants to favorably influence the molecular mechanisms implicated in human disease should be a critical determinant of its selection for clinical studies.
Journal ArticleDOI
Efficacy of oral N-acetylcysteine in the treatment of acetaminophen overdose. Analysis of the national multicenter study (1976 to 1985)
TL;DR: It is concluded that N-acetylcysteine treatment should be started within eight hours of an acetaminophen overdose, but that treatment is still indicated at least as late as 24 hours after ingestion, and it may be superior when treatment is delayed.