Journal ArticleDOI
Biologic and pharmacologic regulation of mammalian glutathione synthesis.
TLDR
Because GSH plays a critical role in cellular defenses against electrophiles, oxidative stress and nitrosating species, pharmacologic manipulation of GSH synthesis has received much attention.About:
This article is published in Free Radical Biology and Medicine.The article was published on 1999-11-01. It has received 1120 citations till now. The article focuses on the topics: Glutathione & Buthionine sulfoximine.read more
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Journal ArticleDOI
Nrf2 in host defense: over the rainbow.
TL;DR: Evidence of NRF2 homeostasis is maintained and adjusted by a tight regulatory circuit according to redox and proteolytic demands indicates that the lysosomal system is the principal mechanism for degrading proteins with long half-lives.
Journal ArticleDOI
Redox sensing and signaling by malaria parasite in vertebrate host.
Satyajit Tripathy,Somenath Roy +1 more
TL;DR: It has been described to understand how redox molecules and NO carry out their diverse functions in both parasites and host and how its regulation carried out by parasite during erythrocytic phase is described.
Journal ArticleDOI
Reproductive effects in hybrid sparrow from a polluted area in Tunisia: Oxidative damage and altered testicular histomorphology
Nahed Amri,Abdessalem Hammouda,Fatma Rahmouni,Med Ali Chokri,Rim Chaabane,Slaheddine Selmi,Tarek Rebai,Riadh Badraoui,Riadh Badraoui +8 more
TL;DR: The results suggest that the hybrid sparrow offers a suitable model for biomonitoring programs of atmosphere pollutants and the selected biomarkers could be useful tool to evaluate pollution impacts in living organisms.
Journal ArticleDOI
Local Glutathione Redox Status Does Not Regulate Ileal Mucosal Growth after Massive Small Bowel Resection in Rats
Junqiang Tian,Naohiro Washizawa,Naohiro Washizawa,Li H. Gu,Marc S. Levin,Marc S. Levin,Lihua Wang,Deborah C. Rubin,Deborah C. Rubin,Simon M. Mwangi,Shanthi Srinivasan,Dean P. Jones,Thomas R. Ziegler +12 more
TL;DR: In vivo data show that marked depletion of ileal GSH and oxidation of the GSH redox pool does not alter indices of ilesal epithelial proliferation or SBR-induced ileAL mucosal adaptive growth.
Journal ArticleDOI
Neuroprotection against neuroblastoma cell death induced by depletion of mitochondrial glutathione.
TL;DR: It is suggested that preventing mitochondrial glutathione depletion could become a novel strategy for the development of neuroprotective therapeutics in neurodegenerative disorders.
References
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The metabolic basis of inherited disease
TL;DR: The metabolic basis of inherited disease, the metabolic basis for inherited disease as mentioned in this paper, The metabolic basis in inherited disease and inherited diseases, and inherited disease diagnosis and management, in the context of inherited diseases
Journal ArticleDOI
Antioxidant and Redox Regulation of Gene Transcription
Chandan K. Sen,Lester Packer +1 more
TL;DR: The efficacy of different antioxidants to favorably influence the molecular mechanisms implicated in human disease should be a critical determinant of its selection for clinical studies.
Journal ArticleDOI
Efficacy of oral N-acetylcysteine in the treatment of acetaminophen overdose. Analysis of the national multicenter study (1976 to 1985)
TL;DR: It is concluded that N-acetylcysteine treatment should be started within eight hours of an acetaminophen overdose, but that treatment is still indicated at least as late as 24 hours after ingestion, and it may be superior when treatment is delayed.