Brain Volumes in Schizophrenia: A Meta-Analysis in Over 18 000 Subjects
Sander V. Haijma,Neeltje E.M. van Haren,Wiepke Cahn,P. Cédric M. P. Koolschijn,Hilleke E. Hulshoff Pol,René S. Kahn +5 more
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TLDR
Brain loss in schizophrenia is related to a combination of (early) neurodevelopmental processes-reflected in intracranial volume reduction-as well as illness progression.Abstract:
Although structural brain alterations in schizophrenia have been demonstrated extensively, their quantitative distribution has not been studied over the last 14 years despite advances in neuroimaging. Moreover, a volumetric meta-analysis has not been conducted in antipsychotic-naive patients. Therefore, meta-analysis on cross-sectional volumetric brain alterations in both medicated and antipsychotic-naive patients was conducted. Three hundred seventeen studies published from September 1, 1998 to January 1, 2012 comprising over 9000 patients were selected for meta-analysis, including 33 studies in antipsychotic-naive patients. In addition to effect sizes, potential modifying factors such as duration of illness, sex composition, current antipsychotic dose, and intelligence quotient matching status of participants were extracted where available. In the sample of medicated schizophrenia patients (n = 8327), intracranial and total brain volume was significantly decreased by 2.0% (effect size d = -0.17) and 2.6% (d = -0.30), respectively. Largest effect sizes were observed for gray matter structures, with effect sizes ranging from -0.22 to -0.58. In the sample of antipsychotic-naive patients (n = 771), volume reductions in caudate nucleus (d = -0.38) and thalamus (d = -0.68) were more pronounced than in medicated patients. White matter volume was decreased to a similar extent in both groups, while gray matter loss was less extensive in antipsychotic-naive patients. Gray matter reduction was associated with longer duration of illness and higher dose of antipsychotic medication at time of scanning. Therefore, brain loss in schizophrenia is related to a combination of (early) neurodevelopmental processes-reflected in intracranial volume reduction-as well as illness progression.read more
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Subcortical brain volume abnormalities in 2028 individuals with schizophrenia and 2540 healthy controls via the ENIGMA consortium
T.G.M. van Erp,Derrek P. Hibar,Jerod M. Rasmussen,David C. Glahn,Godfrey D. Pearlson,Ole A. Andreassen,Ingrid Agartz,Ingrid Agartz,Lars T. Westlye,Lars T. Westlye,Unn K. Haukvik,Anders M. Dale,Ingrid Melle,Cecilie B. Hartberg,Oliver Gruber,Bernd Kraemer,David Zilles,Gary Donohoe,Gary Donohoe,Sinead Kelly,Sinead Kelly,Colm McDonald,Derek W. Morris,Derek W. Morris,Dara M. Cannon,Aiden Corvin,Marise W. J. Machielsen,Laura Koenders,L. de Haan,Dick J. Veltman,Theodore D. Satterthwaite,Daniel H. Wolf,R.C. Gur,R.E. Gur,Steven G. Potkin,Daniel H. Mathalon,Daniel H. Mathalon,Bryon A. Mueller,Adrian Preda,Fabio Macciardi,Stefan Ehrlich,Stefan Ehrlich,Esther Walton,Johanna Hass,Vince D. Calhoun,HJ Bockholt,Scott R. Sponheim,Jody M. Shoemaker,N.E.M. van Haren,Hilleke E. Hulshoff Pol,Roel A. Ophoff,Roel A. Ophoff,René S. Kahn,Roberto Roiz-Santiañez,Benedicto Crespo-Facorro,Lei Wang,Kathryn I. Alpert,Erik G. Jönsson,Erik G. Jönsson,Rali Dimitrova,Catherine Bois,Heather C. Whalley,Andrew M. McIntosh,Stephen M. Lawrie,Ryota Hashimoto,Paul M. Thompson,Jessica A. Turner +66 more
TL;DR: Worldwide cooperative analyses of brain imaging data support a profile of subcortical abnormalities in schizophrenia, which is consistent with that based on traditional meta-analytic approaches, and validates that collaborative data analyses can readily be used across brain phenotypes and disorders.
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Genome-wide association studies of brain imaging phenotypes in UK Biobank
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Progressive brain changes in schizophrenia related to antipsychotic treatment? A meta-analysis of longitudinal MRI studies
Paolo Fusar-Poli,Renata Smieskova,Matthew J. Kempton,Beng-Choon Ho,Nancy C. Andreasen,Stefan Borgwardt +5 more
TL;DR: Schizophrenia is characterized by progressive gray matter volume decreases and lateral ventricular volume increases, and some of these neuroanatomical alterations may be associated with antipsychotic treatment.
Journal ArticleDOI
Abnormal asymmetries in subcortical brain volume in schizophrenia.
Naohiro Okada,Masaki Fukunaga,Fumio Yamashita,Daisuke Koshiyama,Hidenaga Yamamori,Kazutaka Ohi,Yuka Yasuda,Michiko Fujimoto,Yoshifumi Watanabe,Noriaki Yahata,Noriaki Yahata,Kiyotaka Nemoto,Derrek P. Hibar,T.G.M. van Erp,Haruo Fujino,Masanori Isobe,Shuichi Isomura,Tatsunobu Natsubori,Hisashi Narita,Naoki Hashimoto,Jun Miyata,Shinsuke Koike,Tsutomu Takahashi,Hidenori Yamasue,Koji Matsuo,Toshiaki Onitsuka,Tetsuya Iidaka,Yasuhiro Kawasaki,Reiji Yoshimura,Michio Suzuki,Jessica A. Turner,Masatoshi Takeda,Paul M. Thompson,Norio Ozaki,Kiyoto Kasai,Ryota Hashimoto +35 more
TL;DR: The findings suggest the possibility of aberrant laterality in neural pathways and connectivity patterns related to the pallidum in schizophrenia, and replicate the rank order of effect sizes for subcortical volumetric changes in schizophrenia reported by the ENIGMA consortium.
References
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Journal ArticleDOI
Updated meta-analyses reveal thalamus volume reduction in patients with first-episode and chronic schizophrenia
TL;DR: It is confirmed that thalamic volume reduction characterizes patients with schizophrenia, both at the first-episode and chronic phases of the illness.
Journal ArticleDOI
Meta-analysis of the time-course of brain volume reduction in schizophrenia: implications for pathogenesis and early treatment.
TL;DR: There is a small but significant whole brain EBVL in schizophrenia patients both before and after BV(max), regardless of when excessive IVV enlargement is assumed to occur.
Journal ArticleDOI
Letter to the editor: a comment on 'a systematic review of the effects of antipsychotic drugs on brain volume' by Moncrieff & Leo (2010).
TL;DR: An excellent overview of the literature on the association between antipsychotic medication intake and global brain volume changes is provided and it is justified to place more weight on the results of the only large randomized trial, even though it was funded by the manufacturers of olanzapine.
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