Chemokines: A New Classification System and Their Role in Immunity
Albert Zlotnik,Osamu Yoshie +1 more
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This article is published in Immunity.The article was published on 2000-02-01 and is currently open access. It has received 3852 citations till now. The article focuses on the topics: CCL7.read more
Citations
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Inhibition of Japanese encephalitis virus infection by the sulfated polysaccharide extracts from Ulva lactuca.
TL;DR: It is identified that the sulfated polysaccharide extracts from Ulva lactuca can inhibit JEV infection in Vero cells and effectively decrease the production of pro-inflammatory cytokines in the JEV-infected primary mixed glia cells.
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Adaptive and innate immune responses to gene transfer vectors: role of cytokines and chemokines in vector function
TL;DR: Adaptive and innate immune responses to gene transfer vectors: role of cytokines and chemokines in vector function and their role in immune responses are studied.
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Chemokine-related gene expression in the brain following ischemic stroke: No role for CXCR2 in outcome
Vanessa H Brait,Jennifer Rivera,Bradley Rs Broughton,Seyoung Lee,Grant R Drummond,Christopher G. Sobey +5 more
TL;DR: AlthoughSB225002 evidently antagonised the interaction between CXCR2 and its chemokine ligands in the ischemic brain, mice treated with either SB225002 or vehicle had similar motor impairment and infarct volume at 72h, and the reduced expression of CXC chemokines subfamily genes and neutrophil-related infiltration following SB225001 administration did not improve outcome after cerebral ischemia-reperfusion.
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Chimeric antigen receptor modified T cells that target chemokine receptor CCR4 as a therapeutic modality for T-cell malignancies.
Liyanage P. Perera,Meili Zhang,Masao Nakagawa,Michael N. Petrus,Michiyuki Maeda,Marshall E. Kadin,Thomas A. Waldmann,Pin-Yu Perera +7 more
TL;DR: Ex vivo modified, donor‐derived T cells that expressed CCR4 directed CAR displayed antigen‐dependent potent cytotoxicity against patient‐derived cell lines representing ATL, CTCL, ALCL and a subset of HDL illustrating the potential utility of this modality in the treatment of a wide spectrum of T cell malignancies.
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Cytokines and Chemokines in Neuropsychiatric Syndromes of Systemic Lupus Erythematosus
TL;DR: A review of the roles of cytokines and chemokines in NPSLE overviewed the number of recently published studies and found cytokine and Chemokine levels in CSF have been reported as useful diagnostic marker of NPSle.
References
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Two subsets of memory T lymphocytes with distinct homing potentials and effector functions
TL;DR: It is shown that expression of CCR7, a chemokine receptor that controls homing to secondary lymphoid organs, divides human memory T cells into two functionally distinct subsets, which are named central memory (TCM) and effector memory (TEM).
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Function of the chemokine receptor CXCR4 in haematopoiesis and in cerebellar development
TL;DR: This is the first demonstration of the involvement of a G-protein-coupled chemokine receptor in neuronal cell migration and patterning in the central nervous system and may be important for designing strategies to block HIV entry into cells and for understanding mechanisms of pathogenesis in AIDS dementia.
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Defects of B-cell lymphopoiesis and bone-marrow myelopoiesis in mice lacking the CXC chemokine PBSF/SDF-1
Takashi Nagasawa,Seiichi Hirota,Kazunobu Tachibana,Nobuyuki Takakura,Shin-Ichi Nishikawa,Yukihiko Kitamura,Nobuaki Yoshida,Hitoshi Kikutani,Tadamitsu Kishimoto +8 more
TL;DR: It is shown that the chemokine PBSF/SDF-1 has several essential functions in development, including B-cell lymphopoiesis and bone-marrow myelopoiedis and a cardiac ventricular septal defect.
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CCR7 coordinates the primary immune response by establishing functional microenvironments in secondary lymphoid organs.
Reinhold Förster,Andreas Schubel,Dagmar Breitfeld,Elisabeth Kremmer,Ingrid Renner-Müller,Eckhard Wolf,Martin Lipp +6 more
TL;DR: In this paper, the chemokine receptor CCR7 was identified as an important organizer of the primary immune response in mice, and severely delayed kinetics regarding the antibody response and lack contact sensitivity and delayed type hypersensitivity reactions.
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A new class of membrane-bound chemokine with a CX3C motif
J F Bazan,Kevin B. Bacon,Gary Hardiman,W Wang,K Soo,Devora L. Rossi,David R. Greaves,Albert Zlotnik,T J Schall +8 more
TL;DR: The structure, biochemical features, tissue distribution and chromosomal localization of CX3C chemokine all indicate that it represents a unique class of chemokines that may constitute part of the molecular control of leukocyte traffic at the endothelium.