Chemokines: A New Classification System and Their Role in Immunity
Albert Zlotnik,Osamu Yoshie +1 more
Reads0
Chats0
About:
This article is published in Immunity.The article was published on 2000-02-01 and is currently open access. It has received 3852 citations till now. The article focuses on the topics: CCL7.read more
Citations
More filters
Journal ArticleDOI
The Role of Macrophage Inflammatory Protein-1α/CCL3 in Regulation of T Cell-Mediated Immunity to Cryptococcus neoformans Infection
Michal A. Olszewski,Gary B. Huffnagle,Roderick A. McDonald,Dennis M. Lindell,Bethany B. Moore,Donald N. Cook,Galen B. Toews +6 more
TL;DR: It is demonstrated that MIP-1α plays a role in both the afferent (T1/T2 development) and efferent(T1-mediated leukocyte recruitment) phases of cell-mediated immunity to C. neoformans.
Book ChapterDOI
Migration of dendritic cells into lymphatics—The langerhans cell example: Routes, regulation, and relevance
Nikolaus Romani,Gudrun Ratzinger,Kristian Pfaller,Willi Salvenmoser,Hella Stössel,Franz Koch,Patrizia Stoitzner +6 more
TL;DR: The immunogenic/tolerogenic potential of dendritic cells is increasingly being utilized in immunotherapy, particularly for the elicitation of antitumor responses, and the migratory properties of Langerhans cells are reviewed.
Patent
Cyclic derivatives as modulators of chemokine receptor activity
TL;DR: In this paper, the authors describe modulators of MCP-1 of formula (I): or pharmaceutically acceptable salt forms thereof, useful for the treatment of rheumatoid arthritis, multiple sclerosis, atherosclerosis and asthma.
Journal ArticleDOI
Selective CCL5/RANTES-induced mast cell migration through interactions with chemokine receptors CCR1 and CCR4.
TL;DR: Results demonstrate that both CCR1 and CCR4 are functional receptors on human mast cells with capacity to mediate migration towards CCL5.
Journal ArticleDOI
Role of chemokines in thymocyte development.
Anne M. Norment,Michael J. Bevan +1 more
TL;DR: Recent studies of chemokines and their receptors in the thymus are discussed, speculating on their function in the frame work of thymocyte trafficking.
References
More filters
Journal ArticleDOI
Two subsets of memory T lymphocytes with distinct homing potentials and effector functions
TL;DR: It is shown that expression of CCR7, a chemokine receptor that controls homing to secondary lymphoid organs, divides human memory T cells into two functionally distinct subsets, which are named central memory (TCM) and effector memory (TEM).
Journal ArticleDOI
Function of the chemokine receptor CXCR4 in haematopoiesis and in cerebellar development
TL;DR: This is the first demonstration of the involvement of a G-protein-coupled chemokine receptor in neuronal cell migration and patterning in the central nervous system and may be important for designing strategies to block HIV entry into cells and for understanding mechanisms of pathogenesis in AIDS dementia.
Journal ArticleDOI
Defects of B-cell lymphopoiesis and bone-marrow myelopoiesis in mice lacking the CXC chemokine PBSF/SDF-1
Takashi Nagasawa,Seiichi Hirota,Kazunobu Tachibana,Nobuyuki Takakura,Shin-Ichi Nishikawa,Yukihiko Kitamura,Nobuaki Yoshida,Hitoshi Kikutani,Tadamitsu Kishimoto +8 more
TL;DR: It is shown that the chemokine PBSF/SDF-1 has several essential functions in development, including B-cell lymphopoiesis and bone-marrow myelopoiedis and a cardiac ventricular septal defect.
Journal ArticleDOI
CCR7 coordinates the primary immune response by establishing functional microenvironments in secondary lymphoid organs.
Reinhold Förster,Andreas Schubel,Dagmar Breitfeld,Elisabeth Kremmer,Ingrid Renner-Müller,Eckhard Wolf,Martin Lipp +6 more
TL;DR: In this paper, the chemokine receptor CCR7 was identified as an important organizer of the primary immune response in mice, and severely delayed kinetics regarding the antibody response and lack contact sensitivity and delayed type hypersensitivity reactions.
Journal ArticleDOI
A new class of membrane-bound chemokine with a CX3C motif
J F Bazan,Kevin B. Bacon,Gary Hardiman,W Wang,K Soo,Devora L. Rossi,David R. Greaves,Albert Zlotnik,T J Schall +8 more
TL;DR: The structure, biochemical features, tissue distribution and chromosomal localization of CX3C chemokine all indicate that it represents a unique class of chemokines that may constitute part of the molecular control of leukocyte traffic at the endothelium.