Chemokines: A New Classification System and Their Role in Immunity
Albert Zlotnik,Osamu Yoshie +1 more
Reads0
Chats0
About:
This article is published in Immunity.The article was published on 2000-02-01 and is currently open access. It has received 3852 citations till now. The article focuses on the topics: CCL7.read more
Citations
More filters
Journal ArticleDOI
Reactivation of latent tuberculosis infection in TNF-deficient mice.
Tania Botha,Bernhard Ryffel +1 more
TL;DR: Exogenous TNF is critical to maintain latent tuberculosis infection, and in its absence no specific immunity is generated, and despite a massive reduction of the mycobacterial load by chemotherapy, TNF-deficient mice were unable to compensate and mount a protective immune response.
Journal ArticleDOI
Oral Inflammatory Diseases and Systemic Inflammation: Role of the Macrophage
TL;DR: The objective is to identify macrophage-mediated events central to the inflammatory basis of chronic diseases, with an emphasis on how control of macrophages function can be used to prevent or treat harmful outcomes linked to uncontrolled inflammation.
Book ChapterDOI
Involvement of chemokine receptors in organ-specific metastasis.
TL;DR: Many studies have now validated the concept that chemokines and their receptors influence metastasis, and the potential therapeutic importance of these observations depends on the role that each metastatic destination such as liver, lung, bone marrow, etc., plays in the prognosis of a cancer patient.
Journal ArticleDOI
Differential Roles of CC Chemokine Ligand 2/Monocyte Chemotactic Protein-1 and CCR2 in the Development of T1 Immunity
Tim R. Traynor,Amy C. Herring,Martin E. Dorf,William A. Kuziel,Galen B. Toews,Gary B. Huffnagle +5 more
TL;DR: CCR2 (but not CCL2) is required for afferent T1 development in the lymph nodes, but in the absence of CCR2, T1 cells polarize in the LALN, but do not traffic from the lymph node to the lungs, resulting in a pulmonary T2 response.
Journal ArticleDOI
Mast Cell Chemotaxis – Chemoattractants and Signaling Pathways
TL;DR: The major types of chemoattractants recognized by mast cells, their target receptors, as well as signaling pathways they utilize are discussed.
References
More filters
Journal ArticleDOI
Two subsets of memory T lymphocytes with distinct homing potentials and effector functions
TL;DR: It is shown that expression of CCR7, a chemokine receptor that controls homing to secondary lymphoid organs, divides human memory T cells into two functionally distinct subsets, which are named central memory (TCM) and effector memory (TEM).
Journal ArticleDOI
Function of the chemokine receptor CXCR4 in haematopoiesis and in cerebellar development
TL;DR: This is the first demonstration of the involvement of a G-protein-coupled chemokine receptor in neuronal cell migration and patterning in the central nervous system and may be important for designing strategies to block HIV entry into cells and for understanding mechanisms of pathogenesis in AIDS dementia.
Journal ArticleDOI
Defects of B-cell lymphopoiesis and bone-marrow myelopoiesis in mice lacking the CXC chemokine PBSF/SDF-1
Takashi Nagasawa,Seiichi Hirota,Kazunobu Tachibana,Nobuyuki Takakura,Shin-Ichi Nishikawa,Yukihiko Kitamura,Nobuaki Yoshida,Hitoshi Kikutani,Tadamitsu Kishimoto +8 more
TL;DR: It is shown that the chemokine PBSF/SDF-1 has several essential functions in development, including B-cell lymphopoiesis and bone-marrow myelopoiedis and a cardiac ventricular septal defect.
Journal ArticleDOI
CCR7 coordinates the primary immune response by establishing functional microenvironments in secondary lymphoid organs.
Reinhold Förster,Andreas Schubel,Dagmar Breitfeld,Elisabeth Kremmer,Ingrid Renner-Müller,Eckhard Wolf,Martin Lipp +6 more
TL;DR: In this paper, the chemokine receptor CCR7 was identified as an important organizer of the primary immune response in mice, and severely delayed kinetics regarding the antibody response and lack contact sensitivity and delayed type hypersensitivity reactions.
Journal ArticleDOI
A new class of membrane-bound chemokine with a CX3C motif
J F Bazan,Kevin B. Bacon,Gary Hardiman,W Wang,K Soo,Devora L. Rossi,David R. Greaves,Albert Zlotnik,T J Schall +8 more
TL;DR: The structure, biochemical features, tissue distribution and chromosomal localization of CX3C chemokine all indicate that it represents a unique class of chemokines that may constitute part of the molecular control of leukocyte traffic at the endothelium.