Chemokines: A New Classification System and Their Role in Immunity
Albert Zlotnik,Osamu Yoshie +1 more
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This article is published in Immunity.The article was published on 2000-02-01 and is currently open access. It has received 3852 citations till now. The article focuses on the topics: CCL7.read more
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Chemokine Decoy Receptor D6 Plays a Negative Role in Human Breast Cancer
Feng Ying Wu,Zhou Luo Ou,Lan Yun Feng,Jian Min Luo,Lei Ping Wang,Zhen Zhou Shen,Zhi Min Shao +6 more
TL;DR: It is shown for the first time that human breast cancer differentially expressed D6 and the expression could be regulated by some cytokines, and overexpression of D6 inhuman breast cancer cells inhibits proliferation and invasion in vitro and tumorigenesis and lung metastasis in vivo.
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Serum CXCL13 positively correlates with prostatic disease, prostate-specific antigen and mediates prostate cancer cell invasion, integrin clustering and cell adhesion.
Shailesh Singh,Rajesh Singh,Praveen K. Sharma,Udai P. Singh,Shesh N. Rai,Shesh N. Rai,Leland W.K. Chung,Carlton R. Cooper,Kristian R. Novakovic,William E. Grizzle,James W. Lillard,James W. Lillard +11 more
TL;DR: This study presents the first evidence that CXCL13, the only ligand for CXCR5, and IL-6 were significantly elevated in PCa patient serum compared to serum from subjects with benign prostatic hyperplasia, or high-grade prostatic intraepithelial neoplasia as well as normal healthy donors (NHD).
Journal ArticleDOI
The skeleton as a unique environment for breast cancer cells
Andrea M. Mastro,Danny R. Welch +1 more
TL;DR: This review evaluates various properties of the skeleton that contribute to its successful colonization by breast cancer cells, including the unique aspects of the vasculature of metaphyseal bone, which may account for the initial lodging of Breast cancer cells in specific regions of thekeleton.
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IL-17A is essential to the development of elastase-induced pulmonary inflammation and emphysema in mice
Etsuko Kurimoto,Nobuaki Miyahara,Arihiko Kanehiro,Koichi Waseda,Akihiko Taniguchi,Genyo Ikeda,Hikari Koga,Hisakazu Nishimori,Yasushi Tanimoto,Mikio Kataoka,Yoichiro Iwakura,Erwin W. Gelfand,Mitsune Tanimoto +12 more
TL;DR: Targeting IL-17A in emphysema may be a potential therapeutic strategy for delaying disease progression and identify the important contribution of IL- 17A in the development of elastase-induced pulmonary inflammation and emphySEma.
Journal ArticleDOI
Modulation of chemokine receptor activity through dimerization and crosstalk
TL;DR: The integration of signals downstream of chemokine and other receptors will be key to understanding how cells fine-tune their response to a variety of stimuli, including therapeutics.
References
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Two subsets of memory T lymphocytes with distinct homing potentials and effector functions
TL;DR: It is shown that expression of CCR7, a chemokine receptor that controls homing to secondary lymphoid organs, divides human memory T cells into two functionally distinct subsets, which are named central memory (TCM) and effector memory (TEM).
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Function of the chemokine receptor CXCR4 in haematopoiesis and in cerebellar development
TL;DR: This is the first demonstration of the involvement of a G-protein-coupled chemokine receptor in neuronal cell migration and patterning in the central nervous system and may be important for designing strategies to block HIV entry into cells and for understanding mechanisms of pathogenesis in AIDS dementia.
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Defects of B-cell lymphopoiesis and bone-marrow myelopoiesis in mice lacking the CXC chemokine PBSF/SDF-1
Takashi Nagasawa,Seiichi Hirota,Kazunobu Tachibana,Nobuyuki Takakura,Shin-Ichi Nishikawa,Yukihiko Kitamura,Nobuaki Yoshida,Hitoshi Kikutani,Tadamitsu Kishimoto +8 more
TL;DR: It is shown that the chemokine PBSF/SDF-1 has several essential functions in development, including B-cell lymphopoiesis and bone-marrow myelopoiedis and a cardiac ventricular septal defect.
Journal ArticleDOI
CCR7 coordinates the primary immune response by establishing functional microenvironments in secondary lymphoid organs.
Reinhold Förster,Andreas Schubel,Dagmar Breitfeld,Elisabeth Kremmer,Ingrid Renner-Müller,Eckhard Wolf,Martin Lipp +6 more
TL;DR: In this paper, the chemokine receptor CCR7 was identified as an important organizer of the primary immune response in mice, and severely delayed kinetics regarding the antibody response and lack contact sensitivity and delayed type hypersensitivity reactions.
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A new class of membrane-bound chemokine with a CX3C motif
J F Bazan,Kevin B. Bacon,Gary Hardiman,W Wang,K Soo,Devora L. Rossi,David R. Greaves,Albert Zlotnik,T J Schall +8 more
TL;DR: The structure, biochemical features, tissue distribution and chromosomal localization of CX3C chemokine all indicate that it represents a unique class of chemokines that may constitute part of the molecular control of leukocyte traffic at the endothelium.