Chemokines: A New Classification System and Their Role in Immunity
Albert Zlotnik,Osamu Yoshie +1 more
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This article is published in Immunity.The article was published on 2000-02-01 and is currently open access. It has received 3852 citations till now. The article focuses on the topics: CCL7.read more
Citations
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Site-directed mutagenesis of CC chemokine receptor 1 reveals the mechanism of action of UCB 35625, a small molecule chemokine receptor antagonist.
Filipa Lopes de Mendonça,Paula C. A. da Fonseca,Rhian M. Phillips,José W. Saldanha,Timothy J. Williams,James E. Pease +5 more
TL;DR: Molecular modeling suggests that the antagonist ligates TM1, 2, and 7 of CCR1 and severely impedes access to TM2 and TM3, a region thought to be perturbed by the chemokine amino terminus during the process of receptor activation.
Journal ArticleDOI
Genetic Susceptibility to Atopic Dermatitis
TL;DR: Consortia and international collaborative studies, which may maximize study efficacy and overcome the limitations of individual studies, are needed to help further illuminate the complex landscape of AD risk and genetic variations.
Journal ArticleDOI
Differential Production of Th1- and Th2-Type Chemokines by Mouse Langerhans Cells and Splenic Dendritic Cells
Hideki Fujita,Akihiko Asahina,Makoto Sugaya,Koichiro Nakamura,Ping Gao,Hiromi Fujiwara,Kunihiko Tamaki +6 more
TL;DR: Th1- and Th2-type chemokines produced by LC were shown to be functional using chemokine receptor-transfected-2B4 T cells, and the high production of CC chemokin receptor 4 ligands by LC in the absence of IFN-gamma may be an important character discriminating LC from other DC.
Journal ArticleDOI
Expression profile of chemokines and chemokine receptors in epithelial cell layers of oral lichen planus
Mana Ichimura,Koichi Hiratsuka,Naomi Ogura,Tadahiko Utsunomiya,Hiroyuki Sakamaki,Toshirou Kondoh,Yoshimitsu Abiko,Shigeo Otake,Masafumi Yamamoto +8 more
TL;DR: Infiltration of LCs is orchestrated by CCR6, and LCs residing in the lesional epithelia of OLP may be a mature phenotype, and infiltration of T cells in OLP could be mediated by signaling pathways through CXCR3 and CCR5.
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NFATc3 regulates trypsinogen activation, neutrophil recruitment, and tissue damage in acute pancreatitis in mice.
Darbaz Awla,Anna V. Zetterqvist,Aree Abdulla,C. Camello,Lisa Berglund,Peter Spégel,Maria J. Pozo,Pedro J. Camello,Sara Regnér,Maria F. Gomez,Henrik Thorlacius +10 more
TL;DR: NFATc3 regulates trypsinogen activation, inflammation, and pancreatic tissue damage during development of AP in mice and might be a therapeutic target.
References
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Journal ArticleDOI
Two subsets of memory T lymphocytes with distinct homing potentials and effector functions
TL;DR: It is shown that expression of CCR7, a chemokine receptor that controls homing to secondary lymphoid organs, divides human memory T cells into two functionally distinct subsets, which are named central memory (TCM) and effector memory (TEM).
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Function of the chemokine receptor CXCR4 in haematopoiesis and in cerebellar development
TL;DR: This is the first demonstration of the involvement of a G-protein-coupled chemokine receptor in neuronal cell migration and patterning in the central nervous system and may be important for designing strategies to block HIV entry into cells and for understanding mechanisms of pathogenesis in AIDS dementia.
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Defects of B-cell lymphopoiesis and bone-marrow myelopoiesis in mice lacking the CXC chemokine PBSF/SDF-1
Takashi Nagasawa,Seiichi Hirota,Kazunobu Tachibana,Nobuyuki Takakura,Shin-Ichi Nishikawa,Yukihiko Kitamura,Nobuaki Yoshida,Hitoshi Kikutani,Tadamitsu Kishimoto +8 more
TL;DR: It is shown that the chemokine PBSF/SDF-1 has several essential functions in development, including B-cell lymphopoiesis and bone-marrow myelopoiedis and a cardiac ventricular septal defect.
Journal ArticleDOI
CCR7 coordinates the primary immune response by establishing functional microenvironments in secondary lymphoid organs.
Reinhold Förster,Andreas Schubel,Dagmar Breitfeld,Elisabeth Kremmer,Ingrid Renner-Müller,Eckhard Wolf,Martin Lipp +6 more
TL;DR: In this paper, the chemokine receptor CCR7 was identified as an important organizer of the primary immune response in mice, and severely delayed kinetics regarding the antibody response and lack contact sensitivity and delayed type hypersensitivity reactions.
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A new class of membrane-bound chemokine with a CX3C motif
J F Bazan,Kevin B. Bacon,Gary Hardiman,W Wang,K Soo,Devora L. Rossi,David R. Greaves,Albert Zlotnik,T J Schall +8 more
TL;DR: The structure, biochemical features, tissue distribution and chromosomal localization of CX3C chemokine all indicate that it represents a unique class of chemokines that may constitute part of the molecular control of leukocyte traffic at the endothelium.