Chemokines: A New Classification System and Their Role in Immunity
Albert Zlotnik,Osamu Yoshie +1 more
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This article is published in Immunity.The article was published on 2000-02-01 and is currently open access. It has received 3852 citations till now. The article focuses on the topics: CCL7.read more
Citations
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CXCL10: A candidate biomarker in transplantation
Paola Romagnani,Clara Crescioli +1 more
TL;DR: The critical role of CXCL10 in the pathogenesis of allograft rejection following organ transplantation is examined to highlight its potential utilization not only as a therapeutic target but also as a biomarker to predict the severity of rejection, to monitor the inflammatory status of organ recipients and to fine-tune patient therapy in transplantation.
Journal ArticleDOI
Reproducing the molecular subclassification of peripheral T-cell lymphoma–NOS by immunohistochemistry
Catalina Amador,Timothy C. Greiner,Tayla Heavican,Lynette M. Smith,Karen Tatiana Galvis,Waseem Gul Lone,Alyssa Bouska,Francesco d'Amore,Martin Bjerregård Pedersen,Stefano Pileri,Stefano Pileri,Claudio Agostinelli,Andrew L. Feldman,Andreas Rosenwald,German Ott,Anja Mottok,Anja Mottok,Kerry J. Savage,Laurence de Leval,Philippe Gaulard,Soon Thye Lim,Choon Kiat Ong,Sarah L. Ondrejka,Joo Y. Song,Elias Campo,Elaine S. Jaffe,Louis M. Staudt,Lisa M. Rimsza,Julie M. Vose,Dennis D. Weisenburger,Wing C. Chan,Javeed Iqbal +31 more
TL;DR: An immunohistochemistry (IHC) algorithm is generated to identify the two subtypes in paraffin tissue using antibodies to key transcriptional factors (GATA3 and TBX21) and their target proteins and will aid the future clinical management of patients and facilitate risk stratification in clinical trials.
Journal ArticleDOI
Quantitative Differences in Chemokine Receptor Engagement Generate Diversity in Integrin-Dependent Lymphocyte Adhesion
Daniele D’Ambrosio,Cristina Albanesi,Rosmarie Lang,Giampiero Girolomoni,Francesco Sinigaglia,Carlo Laudanna +5 more
TL;DR: Investigation of the biological significance of distinct chemokines binding to the same receptor shows how quantitative variations in chemokine receptor expression level and ligand engagement may alter the selectivity of integrin-dependent lymphocyte adhesive responses, suggesting a mechanism by which chemokin networks may either generate or break the specificity of lymphocyte subset recruitment.
Journal ArticleDOI
Identification of Chemokines Important for Leukocyte Recruitment to the Human Endometrium at the Times of Embryo Implantation and Menstruation
TL;DR: This is the first study to use an unbiased approach to screen for endometrial chemokines, and it is reported that chemokine mRNA was generally up-regulated during endometrian receptivity and early pregnancy, particularly of macrophage and natural killer chemoattractants.
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Fractalkine (CX3CL1) and Brain Inflammation: Implications for HIV-1-Associated Dementia
Robin L. Cotter,C Williams,C Williams,L Ryan,L Ryan,David Erichsen,David Erichsen,A Lopez,A Lopez,Hui Peng,Hui Peng,Jialin C. Zheng,Jialin C. Zheng +12 more
TL;DR: Constitutively expressed in the central nervous system (CNS), mainly by neurons, FKN is up-regulated and released in response to proinflammatory stimuli, and up- regulated in the brain tissue and cerebrospinal fluid of HAD patients.
References
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Two subsets of memory T lymphocytes with distinct homing potentials and effector functions
TL;DR: It is shown that expression of CCR7, a chemokine receptor that controls homing to secondary lymphoid organs, divides human memory T cells into two functionally distinct subsets, which are named central memory (TCM) and effector memory (TEM).
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Function of the chemokine receptor CXCR4 in haematopoiesis and in cerebellar development
TL;DR: This is the first demonstration of the involvement of a G-protein-coupled chemokine receptor in neuronal cell migration and patterning in the central nervous system and may be important for designing strategies to block HIV entry into cells and for understanding mechanisms of pathogenesis in AIDS dementia.
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Defects of B-cell lymphopoiesis and bone-marrow myelopoiesis in mice lacking the CXC chemokine PBSF/SDF-1
Takashi Nagasawa,Seiichi Hirota,Kazunobu Tachibana,Nobuyuki Takakura,Shin-Ichi Nishikawa,Yukihiko Kitamura,Nobuaki Yoshida,Hitoshi Kikutani,Tadamitsu Kishimoto +8 more
TL;DR: It is shown that the chemokine PBSF/SDF-1 has several essential functions in development, including B-cell lymphopoiesis and bone-marrow myelopoiedis and a cardiac ventricular septal defect.
Journal ArticleDOI
CCR7 coordinates the primary immune response by establishing functional microenvironments in secondary lymphoid organs.
Reinhold Förster,Andreas Schubel,Dagmar Breitfeld,Elisabeth Kremmer,Ingrid Renner-Müller,Eckhard Wolf,Martin Lipp +6 more
TL;DR: In this paper, the chemokine receptor CCR7 was identified as an important organizer of the primary immune response in mice, and severely delayed kinetics regarding the antibody response and lack contact sensitivity and delayed type hypersensitivity reactions.
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A new class of membrane-bound chemokine with a CX3C motif
J F Bazan,Kevin B. Bacon,Gary Hardiman,W Wang,K Soo,Devora L. Rossi,David R. Greaves,Albert Zlotnik,T J Schall +8 more
TL;DR: The structure, biochemical features, tissue distribution and chromosomal localization of CX3C chemokine all indicate that it represents a unique class of chemokines that may constitute part of the molecular control of leukocyte traffic at the endothelium.