Chemokines: A New Classification System and Their Role in Immunity
Albert Zlotnik,Osamu Yoshie +1 more
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This article is published in Immunity.The article was published on 2000-02-01 and is currently open access. It has received 3852 citations till now. The article focuses on the topics: CCL7.read more
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Bone Metastases: Molecular Mechanisms and Novel Therapeutic Interventions
TL;DR: Based on the recent literature and data, the need for designing novel agents that will efficiently disrupt interactions among cancer cells and bone microenvironment is seen, bringing hope for more effective treatments.
Journal ArticleDOI
Pathogenic roles of tumor necrosis factor receptor p55-mediated signals in dimethylnitrosamine-induced murine liver fibrosis.
Kazuya Kitamura,Yasunari Nakamoto,Mariko Akiyama,Chifumi Fujii,Toshikazu Kondo,Kenichi Kobayashi,Shuichi Kaneko,Naofumi Mukaida +7 more
TL;DR: In this article, 10 mg/kg of dimethylnitrosamine, a specific hepatotoxicant, was administered twice a week into the peritoneal cavity of both TNFRp55 knock-out (KO) and wild-type mice, and the severity of fibrosis was monitored histologically and biochemically.
Journal ArticleDOI
New chemokine targets for asthma therapy
TL;DR: In vitro and in vivo experimental studies in murine models of asthma as well as evidence from patients with asthma confirm the role of these chemokines and their receptors, establishing a subset of chemokine/chemokine receptor that is potentially important in allergic inflammation.
Journal ArticleDOI
Dissecting the role of infections in atopic dermatitis.
TL;DR: Clinical studies and further efforts in basic research are needed to elucidate the different interactions of the skin immune system and microbes in atopic dermatitis, and to break the vicious circle of cutaneous inflammation.
Journal ArticleDOI
Cross reactivity of three T cell attracting murine chemokines stimulating the CXC chemokine receptor CXCR3 and their induction in cultured cells and during allograft rejection.
Martina Meyer,Paul J. Hensbergen,Elisabeth M. H. van der Raaij-Helmer,Gerald Brandacher,Raimund Margreiter,Christine Heufler,Franz Koch,Shosaku Narumi,Ernst R. Werner,Richard A. Colvin,Andrew D. Luster,Cornelis P. Tensen,Gabriele Werner-Felmayer +12 more
TL;DR: In vivo, the three chemokines are constitutively expressed in various tissues from healthy BALB/c mice and were strongly up‐regulated during rejection of allogeneic heart transplants.
References
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Two subsets of memory T lymphocytes with distinct homing potentials and effector functions
TL;DR: It is shown that expression of CCR7, a chemokine receptor that controls homing to secondary lymphoid organs, divides human memory T cells into two functionally distinct subsets, which are named central memory (TCM) and effector memory (TEM).
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Function of the chemokine receptor CXCR4 in haematopoiesis and in cerebellar development
TL;DR: This is the first demonstration of the involvement of a G-protein-coupled chemokine receptor in neuronal cell migration and patterning in the central nervous system and may be important for designing strategies to block HIV entry into cells and for understanding mechanisms of pathogenesis in AIDS dementia.
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Defects of B-cell lymphopoiesis and bone-marrow myelopoiesis in mice lacking the CXC chemokine PBSF/SDF-1
Takashi Nagasawa,Seiichi Hirota,Kazunobu Tachibana,Nobuyuki Takakura,Shin-Ichi Nishikawa,Yukihiko Kitamura,Nobuaki Yoshida,Hitoshi Kikutani,Tadamitsu Kishimoto +8 more
TL;DR: It is shown that the chemokine PBSF/SDF-1 has several essential functions in development, including B-cell lymphopoiesis and bone-marrow myelopoiedis and a cardiac ventricular septal defect.
Journal ArticleDOI
CCR7 coordinates the primary immune response by establishing functional microenvironments in secondary lymphoid organs.
Reinhold Förster,Andreas Schubel,Dagmar Breitfeld,Elisabeth Kremmer,Ingrid Renner-Müller,Eckhard Wolf,Martin Lipp +6 more
TL;DR: In this paper, the chemokine receptor CCR7 was identified as an important organizer of the primary immune response in mice, and severely delayed kinetics regarding the antibody response and lack contact sensitivity and delayed type hypersensitivity reactions.
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A new class of membrane-bound chemokine with a CX3C motif
J F Bazan,Kevin B. Bacon,Gary Hardiman,W Wang,K Soo,Devora L. Rossi,David R. Greaves,Albert Zlotnik,T J Schall +8 more
TL;DR: The structure, biochemical features, tissue distribution and chromosomal localization of CX3C chemokine all indicate that it represents a unique class of chemokines that may constitute part of the molecular control of leukocyte traffic at the endothelium.