Chemokines: A New Classification System and Their Role in Immunity
Albert Zlotnik,Osamu Yoshie +1 more
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This article is published in Immunity.The article was published on 2000-02-01 and is currently open access. It has received 3852 citations till now. The article focuses on the topics: CCL7.read more
Citations
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Differential expression of cytokines in response to respiratory syncytial virus infection of calves with high or low circulating 25-hydroxyvitamin D3.
Randy E. Sacco,Brian J. Nonnecke,Mitchell V. Palmer,W. Ray Waters,John D. Lippolis,Timothy A. Reinhardt +5 more
TL;DR: It is shown for the first time that RSV infection activates the vitamin D intracrine pathway in the inflamed lung, however, it is observed that cytokines frequently inhibited by this pathway in vitro are, in fact, either significantly upregulated or unaffected in the lungs of RSV-infected calves with high circulating levels of 25(OH)D3.
Journal ArticleDOI
Targeting IL-8 in colorectal cancer.
Yan Ning,Heinz-Josef Lenz +1 more
TL;DR: This review provides an update on the roles of IL-8 and its receptors in colorectal cancer preclinical models and translational relevance and suggests that IL-7 and its receptor CXCR2 may function as significant regulatory factors within the tumor microenvironment and be important therapeutic targets in colOREctal cancers.
Journal ArticleDOI
The chemokine system: tuning and shaping by regulation of receptor expression and coupling in polarized responses.
Massimo Locati,Karel Otero,Tiziana Schioppa,Paola Signorelli,Patrick Perrier,Stefania Baviera,Silvano Sozzani,Silvano Sozzani,Alberto Mantovani,Alberto Mantovani +9 more
TL;DR: CC chemokines eponymous function is represented by induction of leukocyte migration, but these molecules also affect angiogenesis, collagen production and the proliferation of hematopoietic precursors.
Journal ArticleDOI
The chemokine receptor CXCR4 strongly promotes neuroblastoma primary tumour and metastatic growth, but not invasion.
Roland Meier,Annick Mühlethaler-Mottet,Marjorie Flahaut,Aurélie Coulon,Carlo Fusco,Fawzia Louache,Katya Auderset,Katia Balmas Bourloud,Estelle Daudigeos,Curzio Rüegg,Gilles Vassal,Nicole Gross,Jean-Marc Joseph +12 more
TL;DR: A yet unreported NB-specific predominant growth and survival-promoting role of CXCR4 is revealed, which warrants a critical reconsideration of the role of cxCR4 in the malignant behaviour of NB and other cancers.
Journal ArticleDOI
Idiopathic pulmonary fibrosis fibroblasts migrate and proliferate to CC chemokine ligand 21
Elizabeth Pierce,Kristin J. Carpenter,Claudia Jakubzick,S L Kunkel,Holly L. Evanoff,Kevin R. Flaherty,Fernando J. Martinez,Galen B. Toews,Cory M. Hogaboam +8 more
TL;DR: Examining the functional and signalling significance of CCR7 expression of primary fibroblasts grown from IPF/UIP and normal surgical lung biopsy specimens demonstrated that CC chemokine ligand 21 modulates the functional properties of idiopathic pulmonary fibrosis/usual interstitial pneumonia fibro Blasts, but not normal fibroBlasts.
References
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Two subsets of memory T lymphocytes with distinct homing potentials and effector functions
TL;DR: It is shown that expression of CCR7, a chemokine receptor that controls homing to secondary lymphoid organs, divides human memory T cells into two functionally distinct subsets, which are named central memory (TCM) and effector memory (TEM).
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Function of the chemokine receptor CXCR4 in haematopoiesis and in cerebellar development
TL;DR: This is the first demonstration of the involvement of a G-protein-coupled chemokine receptor in neuronal cell migration and patterning in the central nervous system and may be important for designing strategies to block HIV entry into cells and for understanding mechanisms of pathogenesis in AIDS dementia.
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Defects of B-cell lymphopoiesis and bone-marrow myelopoiesis in mice lacking the CXC chemokine PBSF/SDF-1
Takashi Nagasawa,Seiichi Hirota,Kazunobu Tachibana,Nobuyuki Takakura,Shin-Ichi Nishikawa,Yukihiko Kitamura,Nobuaki Yoshida,Hitoshi Kikutani,Tadamitsu Kishimoto +8 more
TL;DR: It is shown that the chemokine PBSF/SDF-1 has several essential functions in development, including B-cell lymphopoiesis and bone-marrow myelopoiedis and a cardiac ventricular septal defect.
Journal ArticleDOI
CCR7 coordinates the primary immune response by establishing functional microenvironments in secondary lymphoid organs.
Reinhold Förster,Andreas Schubel,Dagmar Breitfeld,Elisabeth Kremmer,Ingrid Renner-Müller,Eckhard Wolf,Martin Lipp +6 more
TL;DR: In this paper, the chemokine receptor CCR7 was identified as an important organizer of the primary immune response in mice, and severely delayed kinetics regarding the antibody response and lack contact sensitivity and delayed type hypersensitivity reactions.
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A new class of membrane-bound chemokine with a CX3C motif
J F Bazan,Kevin B. Bacon,Gary Hardiman,W Wang,K Soo,Devora L. Rossi,David R. Greaves,Albert Zlotnik,T J Schall +8 more
TL;DR: The structure, biochemical features, tissue distribution and chromosomal localization of CX3C chemokine all indicate that it represents a unique class of chemokines that may constitute part of the molecular control of leukocyte traffic at the endothelium.