Chemokines: A New Classification System and Their Role in Immunity
Albert Zlotnik,Osamu Yoshie +1 more
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This article is published in Immunity.The article was published on 2000-02-01 and is currently open access. It has received 3852 citations till now. The article focuses on the topics: CCL7.read more
Citations
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2. Cytokines and chemokines.
Larry Borish,John W. Steinke +1 more
TL;DR: Cytokines are grouped according to those that are mononuclear phagocytic-derived or T-lymphocyte-derived; that mediate cytotoxic (antiviral and anticancer), humoral, cell-mediated, or allergic immunity; and that are immunosuppressive.
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Chemokines in pathology and medicine.
TL;DR: The Kessler Institute for Biomedicine and Institute for Research in Biomedicaine in Bellinzona, Switzerland, and Theodor Kocher Institute, University of Bern, are using nanofiltration membranes for the first time to study the role of phosphorous in the immune response to chemotherapy.
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Mammalian defensins in immunity: more than just microbicidal.
TL;DR: Although showing similarity in activity and overall tertiary structure, the evolutionary relationship between defensins and chemokines remains to be determined.
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An alternatively spliced variant of CXCR3 mediates the inhibition of endothelial cell growth induced by IP-10, Mig, and I-TAC, and acts as functional receptor for platelet factor 4.
Laura Lasagni,Michela Francalanci,Francesco Annunziato,Elena Lazzeri,Stefano Giannini,Lorenzo Cosmi,Costanza Sagrinati,Benedetta Mazzinghi,Claudio Orlando,Enrico Maggi,Fabio Marra,Sergio Romagnani,Mario Serio,Paola Romagnani +13 more
TL;DR: A distinct, previously unrecognized receptor named CXCR3-B is described, derived from an alternative splicing of the CX CR3 gene that mediates the angiostatic activity of CxCR3 ligands and also acts as functional receptor for CXCL4.
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A transmembrane CXC chemokine is a ligand for HIV-coreceptor Bonzo.
TL;DR: A protein with the hallmarks of a chemokine, designated CXCL16, that is made by dendritic cells in lymphoid organ T cell zones and by cells in the splenic red pulp is described, indicating roles in thymocyte development and effector T cell trafficking.
References
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Two subsets of memory T lymphocytes with distinct homing potentials and effector functions
TL;DR: It is shown that expression of CCR7, a chemokine receptor that controls homing to secondary lymphoid organs, divides human memory T cells into two functionally distinct subsets, which are named central memory (TCM) and effector memory (TEM).
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Function of the chemokine receptor CXCR4 in haematopoiesis and in cerebellar development
TL;DR: This is the first demonstration of the involvement of a G-protein-coupled chemokine receptor in neuronal cell migration and patterning in the central nervous system and may be important for designing strategies to block HIV entry into cells and for understanding mechanisms of pathogenesis in AIDS dementia.
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Defects of B-cell lymphopoiesis and bone-marrow myelopoiesis in mice lacking the CXC chemokine PBSF/SDF-1
Takashi Nagasawa,Seiichi Hirota,Kazunobu Tachibana,Nobuyuki Takakura,Shin-Ichi Nishikawa,Yukihiko Kitamura,Nobuaki Yoshida,Hitoshi Kikutani,Tadamitsu Kishimoto +8 more
TL;DR: It is shown that the chemokine PBSF/SDF-1 has several essential functions in development, including B-cell lymphopoiesis and bone-marrow myelopoiedis and a cardiac ventricular septal defect.
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CCR7 coordinates the primary immune response by establishing functional microenvironments in secondary lymphoid organs.
Reinhold Förster,Andreas Schubel,Dagmar Breitfeld,Elisabeth Kremmer,Ingrid Renner-Müller,Eckhard Wolf,Martin Lipp +6 more
TL;DR: In this paper, the chemokine receptor CCR7 was identified as an important organizer of the primary immune response in mice, and severely delayed kinetics regarding the antibody response and lack contact sensitivity and delayed type hypersensitivity reactions.
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A new class of membrane-bound chemokine with a CX3C motif
J F Bazan,Kevin B. Bacon,Gary Hardiman,W Wang,K Soo,Devora L. Rossi,David R. Greaves,Albert Zlotnik,T J Schall +8 more
TL;DR: The structure, biochemical features, tissue distribution and chromosomal localization of CX3C chemokine all indicate that it represents a unique class of chemokines that may constitute part of the molecular control of leukocyte traffic at the endothelium.