Chemokines: A New Classification System and Their Role in Immunity
Albert Zlotnik,Osamu Yoshie +1 more
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This article is published in Immunity.The article was published on 2000-02-01 and is currently open access. It has received 3852 citations till now. The article focuses on the topics: CCL7.read more
Citations
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Strategies for chemokine antagonists as therapeutics.
TL;DR: This review discusses the various points of intervention that can be addressed to provide anti-inflammatory and anti-HIV infectivity therapeutics and summarizes the status of the approaches that have been undertaken to produce therapeutics that block chemokine action.
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The anti-inflammatory and antioxidant effects of melatonin on LPS-stimulated bovine mammary epithelial cells.
TL;DR: Melatonin protects bMECs from LPS-induced inflammatory and oxidant stress damage and provides evidence that melatonin might have therapeutic utility in mastitis.
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The strategy of blocking the chemokine system to combat disease.
TL;DR: It is proposed that the prevention of cellular recruitment by blockade of the relevant chemokine receptor/ligand pair would present a novel therapy in that it would act upstream of the therapies currently in use.
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Respiratory Syncytial Virus G and/or SH Glycoproteins Modify CC and CXC Chemokine mRNA Expression in the BALB/c Mouse
TL;DR: Chemokine mRNA expression by pulmonary leukocytes following infection of BALB/c mice with two strains of respiratory syncytial virus (RSV) and one strain of parainfluenza virus type 3 (PIV-3) was determined and the results suggest that RSV G and/or SH proteins inhibit early MIP-1α, Mip-1β, M IP-2, MCP-1, and IP-10 mRNA expression.
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Expression profiling identifies chemokine (C-C motif) ligand 18 as an independent prognostic indicator in gastric cancer.
Suet Yi Leung,Siu Tsan Yuen,Kent-Man Chu,Jonathan A. Mathy,Rui Li,Annie S Y Chan,Simon Law,John Wong,Xin Chen,Samuel So +9 more
TL;DR: This study suggests CCL18 as a novel candidate for antitumor therapeutics and risk stratification in gastric cancer patients and finds that it was expressed by a subpopulation of tumor-associated macrophages that were preferentially located at the tumor invasion front.
References
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Two subsets of memory T lymphocytes with distinct homing potentials and effector functions
TL;DR: It is shown that expression of CCR7, a chemokine receptor that controls homing to secondary lymphoid organs, divides human memory T cells into two functionally distinct subsets, which are named central memory (TCM) and effector memory (TEM).
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Function of the chemokine receptor CXCR4 in haematopoiesis and in cerebellar development
TL;DR: This is the first demonstration of the involvement of a G-protein-coupled chemokine receptor in neuronal cell migration and patterning in the central nervous system and may be important for designing strategies to block HIV entry into cells and for understanding mechanisms of pathogenesis in AIDS dementia.
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Defects of B-cell lymphopoiesis and bone-marrow myelopoiesis in mice lacking the CXC chemokine PBSF/SDF-1
Takashi Nagasawa,Seiichi Hirota,Kazunobu Tachibana,Nobuyuki Takakura,Shin-Ichi Nishikawa,Yukihiko Kitamura,Nobuaki Yoshida,Hitoshi Kikutani,Tadamitsu Kishimoto +8 more
TL;DR: It is shown that the chemokine PBSF/SDF-1 has several essential functions in development, including B-cell lymphopoiesis and bone-marrow myelopoiedis and a cardiac ventricular septal defect.
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CCR7 coordinates the primary immune response by establishing functional microenvironments in secondary lymphoid organs.
Reinhold Förster,Andreas Schubel,Dagmar Breitfeld,Elisabeth Kremmer,Ingrid Renner-Müller,Eckhard Wolf,Martin Lipp +6 more
TL;DR: In this paper, the chemokine receptor CCR7 was identified as an important organizer of the primary immune response in mice, and severely delayed kinetics regarding the antibody response and lack contact sensitivity and delayed type hypersensitivity reactions.
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A new class of membrane-bound chemokine with a CX3C motif
J F Bazan,Kevin B. Bacon,Gary Hardiman,W Wang,K Soo,Devora L. Rossi,David R. Greaves,Albert Zlotnik,T J Schall +8 more
TL;DR: The structure, biochemical features, tissue distribution and chromosomal localization of CX3C chemokine all indicate that it represents a unique class of chemokines that may constitute part of the molecular control of leukocyte traffic at the endothelium.