Chemokines: A New Classification System and Their Role in Immunity
Albert Zlotnik,Osamu Yoshie +1 more
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This article is published in Immunity.The article was published on 2000-02-01 and is currently open access. It has received 3852 citations till now. The article focuses on the topics: CCL7.read more
Citations
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Involvement of chemokine receptors in breast cancer metastasis.
Anja Müller,Bernhard Homey,Hortensia Soto,Nianfeng Ge,Daniel Catron,Matthew E. Buchanan,Terri McClanahan,Erin Murphy,Wei Yuan,Stephan N. Wagner,Jose Luis Barrera,Alejandro Mohar,Emma Verastegui,Albert Zlotnik +13 more
TL;DR: It is reported that the chemokine receptors CXCR4 and CCR7 are highly expressed in human breast cancer cells, malignant breast tumours and metastases and their respective ligands CXCL12/SDF-1α and CCL21/6Ckine exhibit peak levels of expression in organs representing the first destinations of breast cancer metastasis.
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Of mice and not men: differences between mouse and human immunology
TL;DR: Known discrepancies in both innate and adaptive immunity are outlined, including balance of leukocyte subsets, defensins, Toll receptors, inducible NO synthase, the NK inhibitory receptor families Ly49 and KIR, FcR, Ig subsets andChemokine and chemokine receptor expression.
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The microenvironment of the tumour-host interface
Lance A. Liotta,Elise C. Kohn +1 more
TL;DR: A new class of cancer therapies that targets this pathological communication interface between tumour cells and host cells is currently under development.
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Cancer and the chemokine network
TL;DR: Insight is provided into host–tumour interactions, such as the role of the leukocyte infiltrate, and into the mechanisms that determine the metastatic potential and site-specific spread of cancer cells.
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Animal models of acute lung injury.
TL;DR: The goal of this review is to summarize the strengths and weaknesses of existing models of lung injury and help guide investigators in the design and interpretation of animal studies of acute lung injury.
References
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A Putative Chemokine Receptor, BLR1, Directs B Cell Migration to Defined Lymphoid Organs and Specific Anatomic Compartments of the Spleen
TL;DR: The results identify the putative chemokine receptor BLR1 as the first G protein-coupled receptor involved in B cell migration and localization of these cells within specific anatomic compartments.
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Mice Lacking Expression of Secondary Lymphoid Organ Chemokine Have Defects in Lymphocyte Homing and Dendritic Cell Localization
Michael D. Gunn,Shigeru Kyuwa,Carmen Tam,Terutaka Kakiuchi,Akio Matsuzawa,Lewis T. Williams,Hideki Nakano +6 more
TL;DR: It is suggested that the abnormalities in plt mice are due to a genetic defect in the expression of SLC and that SLC mediates the entry of naive T cells and antigen-stimulated DCs into the T cell zones of secondary lymphoid organs.
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Selective Expression of the Eotaxin Receptor CCR3 by Human T Helper 2 Cells
TL;DR: The attraction of TH2 cells by eotaxin could represent a key mechanism in allergic reactions, because it promotes the allergen-driven production of interleukin-4 and interleucin-5 necessary to activate basophils and eosinophils.
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The chemokine receptor CCR4 in vascular recognition by cutaneous but not intestinal memory T cells
James Campbell,James Campbell,Guttorm Haraldsen,Guttorm Haraldsen,Guttorm Haraldsen,Junliang Pan,James B. Rottman,S. Qin,Paul D. Ponath,David P. Andrew,Roger A. Warnke,Nancy Ruffing,Nasim Kassam,Lijun Wu,Eugene C. Butcher,Eugene C. Butcher +15 more
TL;DR: The results suggest that CCR4 and TARC are important in the recognition of skin vasculature by circulating T cells and in directing lymphocytes that are involved in systemic as opposed to intestinal immunity to their target tissues.
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B Cell–attracting Chemokine 1, a Human CXC Chemokine Expressed in Lymphoid Tissues, Selectively Attracts B Lymphocytes via BLR1/CXCR5
Daniel F. Legler,Marcel Loetscher,Regula Stuber Roos,Ian Clark-Lewis,Marco Baggiolini,Bernhard Moser +5 more
TL;DR: The present results indicate that chemotactic recruitment by locally produced BCA-1 is important for the development of B cell areas of secondary lymphoid tissues.