Chemokines: A New Classification System and Their Role in Immunity
Albert Zlotnik,Osamu Yoshie +1 more
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This article is published in Immunity.The article was published on 2000-02-01 and is currently open access. It has received 3852 citations till now. The article focuses on the topics: CCL7.read more
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Cc Chemokine Receptor 2 Is Critical for Induction of Experimental Autoimmune Encephalomyelitis
TL;DR: It is suggested that CCR2 expression on host-derived mononuclear cells is critical for disease induction, and adopted myelin oligodendrocyte glycoprotein 35-55–specific T cells lacking expression of C CR2 were able to induce EAE, whereas CCR 2−/− recipients of wild-type T cells failed to develop disease.
Journal ArticleDOI
Unique subpopulations of CD56+ NK and NK-T peripheral blood lymphocytes identified by chemokine receptor expression repertoire.
James Campbell,Shixin Qin,Derya Unutmaz,Dulce Soler,Kristine E. Murphy,Martin R. Hodge,Lijun Wu,Eugene C. Butcher,Eugene C. Butcher +8 more
TL;DR: A diverse population of cells that may have trafficking patterns entirely different from each other, and from other lymphocyte types are described.
Journal ArticleDOI
Migratory properties of naive, effector, and memory CD8(+) T cells.
TL;DR: Central memory-like CD8IL-15 cells home avidly to lymphoid organs and moderately to sites of inflammation, where they mediate rapid recall responses, whereas CD8 IL-2 effector T cells accumulate in inflamed tissues, but are excluded from most lymphoid organ.
Journal ArticleDOI
Inflammation in Pulmonary Arterial Hypertension
Laura C. Price,S. John Wort,Frédéric Perros,Frédéric Perros,Peter Dorfmüller,Peter Dorfmüller,Alice Huertas,Alice Huertas,David Montani,David Montani,Sylvia Cohen-Kaminsky,Sylvia Cohen-Kaminsky,Marc Humbert,Marc Humbert +13 more
TL;DR: The potential benefit of antiinflammatory therapies in iPAH is of importance and requires further study, and the approach is untested in idiopathic PAH (iPAH).
Journal ArticleDOI
Chemokines, neuronal-glial interactions, and central processing of neuropathic pain.
Yong-Jing Gao,Ru-Rong Ji +1 more
TL;DR: Evidence for chemokine modulation of pain via neuronal- glial interactions by focusing on the central role of two chemokines, CX3CL1 (fractalkine) and CCL2 (MCP-1), because they differentially regulate neuronal-glial interactions is reviewed.
References
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Two subsets of memory T lymphocytes with distinct homing potentials and effector functions
TL;DR: It is shown that expression of CCR7, a chemokine receptor that controls homing to secondary lymphoid organs, divides human memory T cells into two functionally distinct subsets, which are named central memory (TCM) and effector memory (TEM).
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Function of the chemokine receptor CXCR4 in haematopoiesis and in cerebellar development
TL;DR: This is the first demonstration of the involvement of a G-protein-coupled chemokine receptor in neuronal cell migration and patterning in the central nervous system and may be important for designing strategies to block HIV entry into cells and for understanding mechanisms of pathogenesis in AIDS dementia.
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Defects of B-cell lymphopoiesis and bone-marrow myelopoiesis in mice lacking the CXC chemokine PBSF/SDF-1
Takashi Nagasawa,Seiichi Hirota,Kazunobu Tachibana,Nobuyuki Takakura,Shin-Ichi Nishikawa,Yukihiko Kitamura,Nobuaki Yoshida,Hitoshi Kikutani,Tadamitsu Kishimoto +8 more
TL;DR: It is shown that the chemokine PBSF/SDF-1 has several essential functions in development, including B-cell lymphopoiesis and bone-marrow myelopoiedis and a cardiac ventricular septal defect.
Journal ArticleDOI
CCR7 coordinates the primary immune response by establishing functional microenvironments in secondary lymphoid organs.
Reinhold Förster,Andreas Schubel,Dagmar Breitfeld,Elisabeth Kremmer,Ingrid Renner-Müller,Eckhard Wolf,Martin Lipp +6 more
TL;DR: In this paper, the chemokine receptor CCR7 was identified as an important organizer of the primary immune response in mice, and severely delayed kinetics regarding the antibody response and lack contact sensitivity and delayed type hypersensitivity reactions.
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A new class of membrane-bound chemokine with a CX3C motif
J F Bazan,Kevin B. Bacon,Gary Hardiman,W Wang,K Soo,Devora L. Rossi,David R. Greaves,Albert Zlotnik,T J Schall +8 more
TL;DR: The structure, biochemical features, tissue distribution and chromosomal localization of CX3C chemokine all indicate that it represents a unique class of chemokines that may constitute part of the molecular control of leukocyte traffic at the endothelium.