Chemokines: A New Classification System and Their Role in Immunity
Albert Zlotnik,Osamu Yoshie +1 more
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This article is published in Immunity.The article was published on 2000-02-01 and is currently open access. It has received 3852 citations till now. The article focuses on the topics: CCL7.read more
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Neutralization of chemokine-like factor 1, a novel C-C chemokine, protects against focal cerebral ischemia by inhibiting neutrophil infiltration via MAPK pathways in rats
TL;DR: Selective inhibition of CKLF1 activity significantly protects against ischemia/reperfusion injury by decreasing production of inflammatory mediators and expression of adhesion molecules, thereby reducing neutrophils recruitment to the ischemic area, possibly via inhibiting MAPK pathways.
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Macrophage sensing of single-walled carbon nanotubes via Toll-like receptors.
Sourav P. Mukherjee,Olesja Bondarenko,Olesja Bondarenko,Pekka Kohonen,Fernando Torres Andón,Táňa Brzicová,Isabel Gessner,Sanjay Mathur,Massimo Bottini,Paolo Calligari,Lorenzo Stella,Elena R. Kisin,Anna A. Shvedova,Anna A. Shvedova,Reija Autio,Heli Salminen-Mankonen,Riitta Lahesmaa,Bengt Fadeel +17 more
TL;DR: Compared the effects of two carbon-based nanomaterials, single-walled CNTs (SWCNTs) and graphene oxide (GO), on primary human monocyte-derived macrophages, results imply that CNT’s may be ‘sensed’ as pathogens by immune cells.
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The mammalian blastema: regeneration at our fingertips
TL;DR: The stepwise formation of a mammalian blastema is proposed to provide a model for how specific targeted treatments can enhance regenerative performance in humans.
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Minireview: host defence in invasive aspergillosis.
TL;DR: The T‐helper cell (TH1) response is associated with increased production of inflammatory cytokines IFN‐γ, IL‐2 and IL‐12 and stimulation of antifungal effector cells, which promote humoral responses to Aspergillus.
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Lugdunin amplifies innate immune responses in the skin in synergy with host- and microbiota-derived factors
Katharina Bitschar,Birgit Sauer,Jule Focken,Hanna Dehmer,Sonja Moos,Martin C. Konnerth,Nadine A. Schilling,Stephanie Grond,Hubert Kalbacher,Florian C. Kurschus,Florian C. Kurschus,Friedrich Götz,Bernhard Krismer,Andreas Peschel,Birgit Schittek +14 more
TL;DR: It is shown that lugdunin reduces Staphylococcus aureus colonization in human keratinocytes and mouse skin by inducing the expression of human LL-37 and recruitment of monocytes and neutrophils, and may thus become a promising treatment option for S. a Aureus skin infections in the future.
References
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Two subsets of memory T lymphocytes with distinct homing potentials and effector functions
TL;DR: It is shown that expression of CCR7, a chemokine receptor that controls homing to secondary lymphoid organs, divides human memory T cells into two functionally distinct subsets, which are named central memory (TCM) and effector memory (TEM).
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Function of the chemokine receptor CXCR4 in haematopoiesis and in cerebellar development
TL;DR: This is the first demonstration of the involvement of a G-protein-coupled chemokine receptor in neuronal cell migration and patterning in the central nervous system and may be important for designing strategies to block HIV entry into cells and for understanding mechanisms of pathogenesis in AIDS dementia.
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Defects of B-cell lymphopoiesis and bone-marrow myelopoiesis in mice lacking the CXC chemokine PBSF/SDF-1
Takashi Nagasawa,Seiichi Hirota,Kazunobu Tachibana,Nobuyuki Takakura,Shin-Ichi Nishikawa,Yukihiko Kitamura,Nobuaki Yoshida,Hitoshi Kikutani,Tadamitsu Kishimoto +8 more
TL;DR: It is shown that the chemokine PBSF/SDF-1 has several essential functions in development, including B-cell lymphopoiesis and bone-marrow myelopoiedis and a cardiac ventricular septal defect.
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CCR7 coordinates the primary immune response by establishing functional microenvironments in secondary lymphoid organs.
Reinhold Förster,Andreas Schubel,Dagmar Breitfeld,Elisabeth Kremmer,Ingrid Renner-Müller,Eckhard Wolf,Martin Lipp +6 more
TL;DR: In this paper, the chemokine receptor CCR7 was identified as an important organizer of the primary immune response in mice, and severely delayed kinetics regarding the antibody response and lack contact sensitivity and delayed type hypersensitivity reactions.
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A new class of membrane-bound chemokine with a CX3C motif
J F Bazan,Kevin B. Bacon,Gary Hardiman,W Wang,K Soo,Devora L. Rossi,David R. Greaves,Albert Zlotnik,T J Schall +8 more
TL;DR: The structure, biochemical features, tissue distribution and chromosomal localization of CX3C chemokine all indicate that it represents a unique class of chemokines that may constitute part of the molecular control of leukocyte traffic at the endothelium.