Chemokines: A New Classification System and Their Role in Immunity
Albert Zlotnik,Osamu Yoshie +1 more
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This article is published in Immunity.The article was published on 2000-02-01 and is currently open access. It has received 3852 citations till now. The article focuses on the topics: CCL7.read more
Citations
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Stromal cell-derived factor-1 (SDF-1) signalling regulates human placental trophoblast cell survival.
TL;DR: It is indicated that SDF-1/CXCR4 signalling stimulates anti-apoptotic pathways in cultured trophoblasts and this chemotactic ligand/receptor system may promote trophoblast survival during pregnancy.
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Combined administration of resolvin E1 and lipoxin A4 resolves inflammation in a murine model of Alzheimer's disease.
Alpdogan Kantarci,Nurgul Aytan,Nurgul Aytan,Nurgul Aytan,Iro Palaska,Danielle Stephens,Leah Crabtree,Leah Crabtree,Leah Crabtree,Claudia Benincasa,Bruce G. Jenkins,Isabel Carreras,Isabel Carreras,Alpaslan Dedeoglu,Alpaslan Dedeoglu,Alpaslan Dedeoglu +15 more
TL;DR: The study showed that the levels of SPMs in the hippocampus of 5xFAD mice were significantly lower than in wild‐type mice; that treatment with RvE1 and LXA4 restored the level of these compounds, reversed the inflammatory process, and decreased the neuroinflammation associated with A&bgr; pathology in 5xfAD mice.
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Synergistic induction of CXCL9 and CXCL11 by Toll-like receptor ligands and interferon-γ in fibroblasts correlates with elevated levels of CXCR3 ligands in septic arthritis synovial fluids
Paul Proost,Sara Verpoest,Kirsten Van de Borne,Evemie Schutyser,Sofie Struyf,Willy Put,Isabelle Ronsse,B. Grillet,Ghislain Opdenakker,Jozef Van Damme +9 more
TL;DR: The synovial cavity constitutes the ideal stage to study the interplay between microbial Toll‐like receptor (TLR) ligands and cytokines, and the complex interaction between cytokines and TLR ligands in infection is illustrated.
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Monocyte chemoattractant proteins in the pathogenesis of systemic sclerosis
TL;DR: Therapeutic strategies targeting MCP-1 have revealed promising results in several animal models of SSc and represent interesting candidates for target-directed therapy in SSc.
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Platelets: much more than bricks in a breached wall.
TL;DR: The complex role of platelets is discussed, which bridges haemostasis, inflammation and immune response both in physiological and pathological conditions.
References
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Two subsets of memory T lymphocytes with distinct homing potentials and effector functions
TL;DR: It is shown that expression of CCR7, a chemokine receptor that controls homing to secondary lymphoid organs, divides human memory T cells into two functionally distinct subsets, which are named central memory (TCM) and effector memory (TEM).
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Function of the chemokine receptor CXCR4 in haematopoiesis and in cerebellar development
TL;DR: This is the first demonstration of the involvement of a G-protein-coupled chemokine receptor in neuronal cell migration and patterning in the central nervous system and may be important for designing strategies to block HIV entry into cells and for understanding mechanisms of pathogenesis in AIDS dementia.
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Defects of B-cell lymphopoiesis and bone-marrow myelopoiesis in mice lacking the CXC chemokine PBSF/SDF-1
Takashi Nagasawa,Seiichi Hirota,Kazunobu Tachibana,Nobuyuki Takakura,Shin-Ichi Nishikawa,Yukihiko Kitamura,Nobuaki Yoshida,Hitoshi Kikutani,Tadamitsu Kishimoto +8 more
TL;DR: It is shown that the chemokine PBSF/SDF-1 has several essential functions in development, including B-cell lymphopoiesis and bone-marrow myelopoiedis and a cardiac ventricular septal defect.
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CCR7 coordinates the primary immune response by establishing functional microenvironments in secondary lymphoid organs.
Reinhold Förster,Andreas Schubel,Dagmar Breitfeld,Elisabeth Kremmer,Ingrid Renner-Müller,Eckhard Wolf,Martin Lipp +6 more
TL;DR: In this paper, the chemokine receptor CCR7 was identified as an important organizer of the primary immune response in mice, and severely delayed kinetics regarding the antibody response and lack contact sensitivity and delayed type hypersensitivity reactions.
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A new class of membrane-bound chemokine with a CX3C motif
J F Bazan,Kevin B. Bacon,Gary Hardiman,W Wang,K Soo,Devora L. Rossi,David R. Greaves,Albert Zlotnik,T J Schall +8 more
TL;DR: The structure, biochemical features, tissue distribution and chromosomal localization of CX3C chemokine all indicate that it represents a unique class of chemokines that may constitute part of the molecular control of leukocyte traffic at the endothelium.