Chemokines: A New Classification System and Their Role in Immunity
Albert Zlotnik,Osamu Yoshie +1 more
Reads0
Chats0
About:
This article is published in Immunity.The article was published on 2000-02-01 and is currently open access. It has received 3852 citations till now. The article focuses on the topics: CCL7.read more
Citations
More filters
Journal ArticleDOI
Single-dose mucosal immunization with a candidate universal influenza vaccine provides rapid protection from virulent H5N1, H3N2 and H1N1 viruses.
Graeme E. Price,Mark R. Soboleski,Chia-Yun Lo,Julia A. Misplon,Mary R. Quirion,Katherine V. Houser,Melissa B. Pearce,Claudia Pappas,Terrence M. Tumpey,Suzanne L. Epstein +9 more
TL;DR: Mucosal administration of NP and M2-expressing rAd vectors provided rapid and lasting protection from influenza viruses in a subtype-independent manner, and represents a candidate off-the-shelf vaccine for emergency use during an influenza pandemic.
Journal ArticleDOI
Quantitative analysis of chemokine expression by dendritic cell subsets in vitro and in vivo.
Joost L. M. Vissers,Franca C. Hartgers,Ernst Lindhout,Marcel B. M. Teunissen,Carl G. Figdor,Gosse J. Adema +5 more
TL;DR: Indetail the expression of 12 chemokines involved in the recruitment of leukocytes into and inside secondary lymphoid organs, by DCs indistinct differentiation stages, both in vitro and in vivo are studied.
Journal ArticleDOI
Citrullination of CXCL10 and CXCL11 by peptidylarginine deiminase: a naturally occurring posttranslational modification of chemokines and new dimension of immunoregulation
Tamara Loos,Anneleen Mortier,Mieke Gouwy,Isabelle Ronsse,Willy Put,Jean-Pierre Lenaerts,Jozef Van Damme,Paul Proost +7 more
TL;DR: Chemokines are the first immune modulators reported of being functionally modified by citrullination, and new structure-function dimensions for chemokines in leukocyte mobilization are provided, disclosing an anti-inflammatory role for PAD.
Journal ArticleDOI
The Cell Surface-Localized Heat Shock Protein 70 Epitope TKD Induces Migration and Cytolytic Activity Selectively in Human NK Cells
Robert Gastpar,Catharina C. Gross,Lydia Rossbacher,Joachim W. Ellwart,Julia Riegger,Gabriele Multhoff +5 more
TL;DR: It is demonstrated that TKD-activated CD3−CD56+CD94+ NK cells are selectively attracted by Hsp70 membrane-positive tumor cells, and supernatants derived thereof, and Hsp 70 membrane-negative tumors failed to attract these NK cells.
Journal ArticleDOI
The molecular basis of lymphocyte recruitment to the skin: clues for pathogenesis and selective therapies of inflammatory disorders.
TL;DR: Spatial compartmentalization and tissue-selective localization of T lymphocytes to the skin are crucial for immune surveillance and the pathogenesis of various disorders including common inflammatory diseases, but also malignancies such as cutaneous T cell lymphomas.
References
More filters
Journal ArticleDOI
Two subsets of memory T lymphocytes with distinct homing potentials and effector functions
TL;DR: It is shown that expression of CCR7, a chemokine receptor that controls homing to secondary lymphoid organs, divides human memory T cells into two functionally distinct subsets, which are named central memory (TCM) and effector memory (TEM).
Journal ArticleDOI
Function of the chemokine receptor CXCR4 in haematopoiesis and in cerebellar development
TL;DR: This is the first demonstration of the involvement of a G-protein-coupled chemokine receptor in neuronal cell migration and patterning in the central nervous system and may be important for designing strategies to block HIV entry into cells and for understanding mechanisms of pathogenesis in AIDS dementia.
Journal ArticleDOI
Defects of B-cell lymphopoiesis and bone-marrow myelopoiesis in mice lacking the CXC chemokine PBSF/SDF-1
Takashi Nagasawa,Seiichi Hirota,Kazunobu Tachibana,Nobuyuki Takakura,Shin-Ichi Nishikawa,Yukihiko Kitamura,Nobuaki Yoshida,Hitoshi Kikutani,Tadamitsu Kishimoto +8 more
TL;DR: It is shown that the chemokine PBSF/SDF-1 has several essential functions in development, including B-cell lymphopoiesis and bone-marrow myelopoiedis and a cardiac ventricular septal defect.
Journal ArticleDOI
CCR7 coordinates the primary immune response by establishing functional microenvironments in secondary lymphoid organs.
Reinhold Förster,Andreas Schubel,Dagmar Breitfeld,Elisabeth Kremmer,Ingrid Renner-Müller,Eckhard Wolf,Martin Lipp +6 more
TL;DR: In this paper, the chemokine receptor CCR7 was identified as an important organizer of the primary immune response in mice, and severely delayed kinetics regarding the antibody response and lack contact sensitivity and delayed type hypersensitivity reactions.
Journal ArticleDOI
A new class of membrane-bound chemokine with a CX3C motif
J F Bazan,Kevin B. Bacon,Gary Hardiman,W Wang,K Soo,Devora L. Rossi,David R. Greaves,Albert Zlotnik,T J Schall +8 more
TL;DR: The structure, biochemical features, tissue distribution and chromosomal localization of CX3C chemokine all indicate that it represents a unique class of chemokines that may constitute part of the molecular control of leukocyte traffic at the endothelium.