Chemokines: A New Classification System and Their Role in Immunity
Albert Zlotnik,Osamu Yoshie +1 more
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This article is published in Immunity.The article was published on 2000-02-01 and is currently open access. It has received 3852 citations till now. The article focuses on the topics: CCL7.read more
Citations
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Cutting edge: IFN-inducible ELR- CXC chemokines display defensin-like antimicrobial activity.
TL;DR: Members of the IFN-γ-inducible tripeptide motif Glu-Leu-Arg− CXC chemokines were antimicrobial against Escherichia coli and Listeria monocytogenes and suggest that, in tissues with mononuclear cell infiltration, IFN -γ-Inducible chemokine may reach concentrations necessary for microbicidal activity.
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Mast Cells Control Neutrophil Recruitment during T Cell–Mediated Delayed-Type Hypersensitivity Reactions through Tumor Necrosis Factor and Macrophage Inflammatory Protein 2
Tilo Biedermann,Manfred Kneilling,Reinhard Mailhammer,K.L. Maier,Christian A. Sander,George Kollias,Steven L. Kunkel,Lothar Hültner,Martin Röcken +8 more
TL;DR: Analysis of hapten-induced DTHRs of the skin found that mast cells determine the T cell–dependent PMN recruitment through two mediators, tumor necrosis factor (TNF) and the CXC chemokine macrophage inflammatory protein 2 (MIP-2), the functional analogue of human interleukin 8.
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The CCR7 ligand elc (CCL19) is transcytosed in high endothelial venules and mediates T cell recruitment.
Espen S. Baekkevold,Takeshi Yamanaka,Roger T. Palframan,Hege S. Carlsen,Finn P. Reinholt,Ulrich H. von Andrian,Per Brandtzaeg,Guttorm Haraldsen +7 more
TL;DR: It is shown that perivascular ELC is transcytosed to the luminal surfaces of HEVs and participates in CCR7-mediated triggering of lymphocyte arrest.
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The chemokine system and cancer
TL;DR: Chemokines (chemo‐attractant cytokines) are a group of small proteins that act together with their cell surface receptors, in development, normal physiology and immune responses, to direct cells to specific locations throughout the body.
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The Significance of Vasoactive Intestinal Peptide in Immunomodulation
TL;DR: Recognition of the central functions VIP plays in cellular processes is focusing attention on this “very important peptide” as exciting new candidates for therapeutic intervention and drug development.
References
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Two subsets of memory T lymphocytes with distinct homing potentials and effector functions
TL;DR: It is shown that expression of CCR7, a chemokine receptor that controls homing to secondary lymphoid organs, divides human memory T cells into two functionally distinct subsets, which are named central memory (TCM) and effector memory (TEM).
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Function of the chemokine receptor CXCR4 in haematopoiesis and in cerebellar development
TL;DR: This is the first demonstration of the involvement of a G-protein-coupled chemokine receptor in neuronal cell migration and patterning in the central nervous system and may be important for designing strategies to block HIV entry into cells and for understanding mechanisms of pathogenesis in AIDS dementia.
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Defects of B-cell lymphopoiesis and bone-marrow myelopoiesis in mice lacking the CXC chemokine PBSF/SDF-1
Takashi Nagasawa,Seiichi Hirota,Kazunobu Tachibana,Nobuyuki Takakura,Shin-Ichi Nishikawa,Yukihiko Kitamura,Nobuaki Yoshida,Hitoshi Kikutani,Tadamitsu Kishimoto +8 more
TL;DR: It is shown that the chemokine PBSF/SDF-1 has several essential functions in development, including B-cell lymphopoiesis and bone-marrow myelopoiedis and a cardiac ventricular septal defect.
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CCR7 coordinates the primary immune response by establishing functional microenvironments in secondary lymphoid organs.
Reinhold Förster,Andreas Schubel,Dagmar Breitfeld,Elisabeth Kremmer,Ingrid Renner-Müller,Eckhard Wolf,Martin Lipp +6 more
TL;DR: In this paper, the chemokine receptor CCR7 was identified as an important organizer of the primary immune response in mice, and severely delayed kinetics regarding the antibody response and lack contact sensitivity and delayed type hypersensitivity reactions.
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A new class of membrane-bound chemokine with a CX3C motif
J F Bazan,Kevin B. Bacon,Gary Hardiman,W Wang,K Soo,Devora L. Rossi,David R. Greaves,Albert Zlotnik,T J Schall +8 more
TL;DR: The structure, biochemical features, tissue distribution and chromosomal localization of CX3C chemokine all indicate that it represents a unique class of chemokines that may constitute part of the molecular control of leukocyte traffic at the endothelium.