Chemokines: A New Classification System and Their Role in Immunity
Albert Zlotnik,Osamu Yoshie +1 more
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This article is published in Immunity.The article was published on 2000-02-01 and is currently open access. It has received 3852 citations till now. The article focuses on the topics: CCL7.read more
Citations
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Role of apoptosis and cytokines in influenza virus morbidity
TL;DR: The role of apoptosis in respiratory epithelial cell damage and the role of cytokines in inflammation and constitutional symptoms are explored with particular emphasis on the link between apoptosis, inflammation, fever and cytokine production.
Journal ArticleDOI
Identification and characterization of a novel human collectin CL-K1.
Hiroyuki Keshi,Takashi Sakamoto,Takao Kawai,Katsuki Ohtani,Tsuyoshi Katoh,Seongjae Jang,Wataru Motomura,Takayuki Yoshizaki,Mitsuko Fukuda,Satoshi Koyama,Jun Fukuzawa,Atsushi Fukuoh,Itsuro Yoshida,Yasuhiko Suzuki,Nobutaka Wakamiya +14 more
TL;DR: The cloning and characterization of a novel collectin CL‐K1 was reported, which can recognize specially several bacterial saccharides due to specific sugar‐binding character and showed Ca2+‐dependent sugar binding activity of fucose and weakly mannose but not N‐ acetyl‐galactosamine, N‐acetyl‐glucosamines, or maltose, though mannoses‐binding lectin (MBL) containing similar amino acid motif.
Journal ArticleDOI
Fractalkine and vascular injury
TL;DR: A model in which fractalkine mediates vascular injury through the accumulation and activation of killer cells is proposed, which might provide insight into the pathogenesis of vascular injury.
Journal ArticleDOI
The CXC Chemokine Murine Monokine Induced by IFN-γ (CXC Chemokine Ligand 9) Is Made by APCs, Targets Lymphocytes Including Activated B Cells, and Supports Antibody Responses to a Bacterial Pathogen In Vivo
Matthew K. Park,Doron Amichay,Paul E. Love,Elizabeth Wick,Fang Liao,Alex Grinberg,Ronald L. Rabin,Hongwei H. Zhang,Senkuta Gebeyehu,Timothy Michael Wright,Akiko Iwasaki,Youmin Weng,Julie A. DeMartino,Karen L. Elkins,Joshua M. Farber +14 more
TL;DR: The data suggest that Mig and CXCR3 may be important not only to recruit T cells to peripheral inflammatory sites, but also in some cases to maximize interactions among activated T cells, B cells, and dendritic cells within lymphoid organs to provide optimal humoral responses to pathogens.
Journal ArticleDOI
Chemokine expression dynamics in mycobacterial (type-1) and schistosomal (type-2) antigen-elicited pulmonary granuloma formation.
Boqin Qiu,Kirsten A. Frait,Filip Reich,Eric Komuniecki,Stephen W. Chensue,Stephen W. Chensue +5 more
TL;DR: Findings indicate that type-1 and type-2 granulomas display characteristic CK profiles with coordinated expression that is under cytokine-mediated regulation.
References
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Two subsets of memory T lymphocytes with distinct homing potentials and effector functions
TL;DR: It is shown that expression of CCR7, a chemokine receptor that controls homing to secondary lymphoid organs, divides human memory T cells into two functionally distinct subsets, which are named central memory (TCM) and effector memory (TEM).
Journal ArticleDOI
Function of the chemokine receptor CXCR4 in haematopoiesis and in cerebellar development
TL;DR: This is the first demonstration of the involvement of a G-protein-coupled chemokine receptor in neuronal cell migration and patterning in the central nervous system and may be important for designing strategies to block HIV entry into cells and for understanding mechanisms of pathogenesis in AIDS dementia.
Journal ArticleDOI
Defects of B-cell lymphopoiesis and bone-marrow myelopoiesis in mice lacking the CXC chemokine PBSF/SDF-1
Takashi Nagasawa,Seiichi Hirota,Kazunobu Tachibana,Nobuyuki Takakura,Shin-Ichi Nishikawa,Yukihiko Kitamura,Nobuaki Yoshida,Hitoshi Kikutani,Tadamitsu Kishimoto +8 more
TL;DR: It is shown that the chemokine PBSF/SDF-1 has several essential functions in development, including B-cell lymphopoiesis and bone-marrow myelopoiedis and a cardiac ventricular septal defect.
Journal ArticleDOI
CCR7 coordinates the primary immune response by establishing functional microenvironments in secondary lymphoid organs.
Reinhold Förster,Andreas Schubel,Dagmar Breitfeld,Elisabeth Kremmer,Ingrid Renner-Müller,Eckhard Wolf,Martin Lipp +6 more
TL;DR: In this paper, the chemokine receptor CCR7 was identified as an important organizer of the primary immune response in mice, and severely delayed kinetics regarding the antibody response and lack contact sensitivity and delayed type hypersensitivity reactions.
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A new class of membrane-bound chemokine with a CX3C motif
J F Bazan,Kevin B. Bacon,Gary Hardiman,W Wang,K Soo,Devora L. Rossi,David R. Greaves,Albert Zlotnik,T J Schall +8 more
TL;DR: The structure, biochemical features, tissue distribution and chromosomal localization of CX3C chemokine all indicate that it represents a unique class of chemokines that may constitute part of the molecular control of leukocyte traffic at the endothelium.