Chemokines: A New Classification System and Their Role in Immunity
Albert Zlotnik,Osamu Yoshie +1 more
About:
This article is published in Immunity.The article was published on 2000-02-01 and is currently open access. It has received 3852 citations till now. The article focuses on the topics: CCL7.read more
Citations
More filters
Journal ArticleDOI
CCR1 Antagonists: What Have We Learned From Clinical Trials
TL;DR: Evidence that supported the role of CCR1 in these diseases, the results from clinical trials, and perspectives on what has been learned from these trials for potential application / consideration to other studies with chemokine receptor antagonists are described.
Journal ArticleDOI
Distinct roles for IP-10/CXCL10 in three animal models, Theiler's virus infection, EAE, and MHV infection, for multiple sclerosis: Implication of differing roles for IP-10
TL;DR: A difference in the pathogenesis of TMEV infection from that of two other animal models for MS, mouse hepatitis virus infection and experimental allergic encephalomyelitis (EAE), where blocking of IP-10 resulted in clinical and histological improvement with suppression of antigen specific lymphoproliferation is likely reflected.
Journal ArticleDOI
Human osteoblasts express functional CXC chemokine receptors 3 and 5: Activation by their ligands, CXCL10 and CXCL13, significantly induces alkaline phosphatase and β‐N‐acetylhexosaminidase release
Gina Lisignoli,S. Toneguzzi,Anna Piacentini,Luca Cattini,Anna Lenti,Matilde Tschon,Sandra Cristino,Francesco Grassi,Andrea Facchini +8 more
TL;DR: The data suggest that OBs may play a role in the modulation of bone formation through the combined action of these two enzymes.
Journal ArticleDOI
Interaction between CXCR4 and CCL20 pathways regulates tumor growth.
Katia Beider,Michal Abraham,Michal Begin,Hanna Wald,Ido D. Weiss,Ori Wald,Eli Pikarsky,Rinat Abramovitch,Evelyne Zeira,Eithan Galun,Arnon Nagler,Amnon Peled +11 more
TL;DR: A role for CCL20 is revealed in CXCR4-dependent and -independent tumor growth and a therapeutic potential for C CL20 and CCR6 antagonists in the treatment of CX CR4- and CCL 20-dependent malignancies is suggested.
Journal ArticleDOI
CXCR4 chemokine receptor antagonists: perspectives in SCLC.
Jan A. Burger,David J. Stewart +1 more
TL;DR: Targeting the CXCR4–CXCL12 axis is a novel, attractive therapeutic approach in SCLC and the current status of the preclinical and clinical development of CX CR4 antagonists is summarized.
References
More filters
Journal ArticleDOI
Two subsets of memory T lymphocytes with distinct homing potentials and effector functions
TL;DR: It is shown that expression of CCR7, a chemokine receptor that controls homing to secondary lymphoid organs, divides human memory T cells into two functionally distinct subsets, which are named central memory (TCM) and effector memory (TEM).
Journal ArticleDOI
Function of the chemokine receptor CXCR4 in haematopoiesis and in cerebellar development
TL;DR: This is the first demonstration of the involvement of a G-protein-coupled chemokine receptor in neuronal cell migration and patterning in the central nervous system and may be important for designing strategies to block HIV entry into cells and for understanding mechanisms of pathogenesis in AIDS dementia.
Journal ArticleDOI
Defects of B-cell lymphopoiesis and bone-marrow myelopoiesis in mice lacking the CXC chemokine PBSF/SDF-1
Takashi Nagasawa,Seiichi Hirota,Kazunobu Tachibana,Nobuyuki Takakura,Shin-Ichi Nishikawa,Yukihiko Kitamura,Nobuaki Yoshida,Hitoshi Kikutani,Tadamitsu Kishimoto +8 more
TL;DR: It is shown that the chemokine PBSF/SDF-1 has several essential functions in development, including B-cell lymphopoiesis and bone-marrow myelopoiedis and a cardiac ventricular septal defect.
Journal ArticleDOI
CCR7 coordinates the primary immune response by establishing functional microenvironments in secondary lymphoid organs.
Reinhold Förster,Andreas Schubel,Dagmar Breitfeld,Elisabeth Kremmer,Ingrid Renner-Müller,Eckhard Wolf,Martin Lipp +6 more
TL;DR: In this paper, the chemokine receptor CCR7 was identified as an important organizer of the primary immune response in mice, and severely delayed kinetics regarding the antibody response and lack contact sensitivity and delayed type hypersensitivity reactions.
Journal ArticleDOI
A new class of membrane-bound chemokine with a CX3C motif
J F Bazan,Kevin B. Bacon,Gary Hardiman,W Wang,K Soo,Devora L. Rossi,David R. Greaves,Albert Zlotnik,T J Schall +8 more
TL;DR: The structure, biochemical features, tissue distribution and chromosomal localization of CX3C chemokine all indicate that it represents a unique class of chemokines that may constitute part of the molecular control of leukocyte traffic at the endothelium.