Chemokines: A New Classification System and Their Role in Immunity
Albert Zlotnik,Osamu Yoshie +1 more
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This article is published in Immunity.The article was published on 2000-02-01 and is currently open access. It has received 3852 citations till now. The article focuses on the topics: CCL7.read more
Citations
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CC family chemokines directly regulate myoblast responses to skeletal muscle injury.
Linda Yahiaoui,Linda Yahiaoui,Dusanka Gvozdic,Dusanka Gvozdic,Gawiyou Danialou,Gawiyou Danialou,Matthias Mack,Basil J. Petrof,Basil J. Petrof +8 more
TL;DR: The results indicate that CC chemokines have potent and direct effects on myoblast behaviour, thus indicating a novel role in muscle repair beyond leucocyte chemoattraction and interventions aimed at modulating the balance between myobasts and leucocytes in injured muscle could represent a novel strategy for the treatment of destructive muscle pathologies.
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Chemokines and matrix metalloproteinase-9 in leukocyte recruitment to the central nervous system
TL;DR: How chemokines and MMP-9 may be involved in the pathogenesis of MS by controlling leukocyte migration between different functional compartments is reviewed and interfering with their function holds promise as a novel therapeutic strategy in MS.
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Investigating Chemokines and Chemokine Receptors in Patients With Multiple Sclerosis: Opportunities and Challenges
TL;DR: A general model of leukocyte migration into the central nervous system under normal and inflammatory conditions will be proposed, and opportunities and challenges for future investigations will be identified.
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Proinflammatory and profibrotic mediators: principal effectors of leiomyoma development as a fibrotic disorder.
TL;DR: This review addresses the key regulatory functions of proinflammatory and profibrotic mediators and their molecular mechanisms, downstream signaling that regulates cellular events that result in transformation, and commitments of specific cells into forming a cellular environment with a possible role in development and subsequent growth of leiomyomas.
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Illuminating the Onco-GPCRome: Novel G protein–coupled receptor-driven oncocrine networks and targets for cancer immunotherapy
Victoria Wu,Huwate Yeerna,Nijiro Nohata,Joshua Chiou,Olivier Harismendy,Francesco Raimondi,Asuka Inoue,Robert B. Russell,Pablo Tamayo,J. Silvio Gutkind +9 more
TL;DR: A comprehensive analysis of GPCR gene expression, copy number variation, and mutational signatures in 33 cancer types is presented and highlights the emerging role of G PCRs as part of oncocrine networks promoting tumor growth, dissemination, and immune evasion.
References
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Two subsets of memory T lymphocytes with distinct homing potentials and effector functions
TL;DR: It is shown that expression of CCR7, a chemokine receptor that controls homing to secondary lymphoid organs, divides human memory T cells into two functionally distinct subsets, which are named central memory (TCM) and effector memory (TEM).
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Function of the chemokine receptor CXCR4 in haematopoiesis and in cerebellar development
TL;DR: This is the first demonstration of the involvement of a G-protein-coupled chemokine receptor in neuronal cell migration and patterning in the central nervous system and may be important for designing strategies to block HIV entry into cells and for understanding mechanisms of pathogenesis in AIDS dementia.
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Defects of B-cell lymphopoiesis and bone-marrow myelopoiesis in mice lacking the CXC chemokine PBSF/SDF-1
Takashi Nagasawa,Seiichi Hirota,Kazunobu Tachibana,Nobuyuki Takakura,Shin-Ichi Nishikawa,Yukihiko Kitamura,Nobuaki Yoshida,Hitoshi Kikutani,Tadamitsu Kishimoto +8 more
TL;DR: It is shown that the chemokine PBSF/SDF-1 has several essential functions in development, including B-cell lymphopoiesis and bone-marrow myelopoiedis and a cardiac ventricular septal defect.
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CCR7 coordinates the primary immune response by establishing functional microenvironments in secondary lymphoid organs.
Reinhold Förster,Andreas Schubel,Dagmar Breitfeld,Elisabeth Kremmer,Ingrid Renner-Müller,Eckhard Wolf,Martin Lipp +6 more
TL;DR: In this paper, the chemokine receptor CCR7 was identified as an important organizer of the primary immune response in mice, and severely delayed kinetics regarding the antibody response and lack contact sensitivity and delayed type hypersensitivity reactions.
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A new class of membrane-bound chemokine with a CX3C motif
J F Bazan,Kevin B. Bacon,Gary Hardiman,W Wang,K Soo,Devora L. Rossi,David R. Greaves,Albert Zlotnik,T J Schall +8 more
TL;DR: The structure, biochemical features, tissue distribution and chromosomal localization of CX3C chemokine all indicate that it represents a unique class of chemokines that may constitute part of the molecular control of leukocyte traffic at the endothelium.