Chemokines: A New Classification System and Their Role in Immunity
Albert Zlotnik,Osamu Yoshie +1 more
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This article is published in Immunity.The article was published on 2000-02-01 and is currently open access. It has received 3852 citations till now. The article focuses on the topics: CCL7.read more
Citations
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Expression of chemokine receptors by lung T cells from normal and asthmatic subjects.
James Campbell,Christopher E. Brightling,F A Symon,Shi Qin,Kristine E. Murphy,Mmarty Hodge,David P. Andrew,Lijun Wu,Eugene C. Butcher,Andrew J. Wardlaw +9 more
TL;DR: This study provides added support for the concept of a lung-homing pathway separate from other mucosal organs such as the gut and suggests that the chemokine pathways that control T cell migration in normal homeostasis and Th2-type inflammatory responses are similar.
Journal ArticleDOI
Targeting leukocyte migration and adhesion in Crohn’s disease and ulcerative colitis
Saskia Thomas,Daniel C. Baumgart +1 more
TL;DR: The immunological mechanisms of leukocyte homing and adhesion in the gut mucosa are discussed and the clinical trial results of approved and investigational antibodies and small molecules including natalizumab are discussed.
Journal ArticleDOI
Chemokines and their receptors in allograft rejection
TL;DR: Despite current recognition of over 40 chemokines and more than 18 chemokine receptors, understanding of their role in transplant immunobiology and transplant rejection is extremely limited and fragmentary.
Journal ArticleDOI
Tracking CD40 signaling during germinal center development.
Katia Basso,Ulf Klein,Huifeng Niu,Gustavo Stolovitzky,Yuhai Tu,Andrea Califano,Giorgio Cattoretti,Riccardo Dalla-Favera +7 more
TL;DR: Results show that GC expansion occurs in the absence of CD40 signaling, which may act only in the initial and final stages of the GC reaction.
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IP-10 and Mig Production by Glomerular Cells in Human Proliferative Glomerulonephritis and Regulation by Nitric Oxide
Paola Romagnani,Elena Lazzeri,Laura Lasagni,Carmelo Mavilia,Chiara Beltrame,Michela Francalanci,Mario Rotondi,Francesco Annunziato,Lucia Maurenzig,Lorenzo Cosmi,Grazia Galli,Maurizio Salvadori,Enrico Maggi,Mario Serio +13 more
TL;DR: A significant blood-to-dialysate flow mismatch may occur in hollow-fiber hemodialyzers due to either uneven blood flow distribution or a dialysate channeling phenomenon external to the fiber bundle, and improvement in dialyzer design may overcome these problems.
References
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Two subsets of memory T lymphocytes with distinct homing potentials and effector functions
TL;DR: It is shown that expression of CCR7, a chemokine receptor that controls homing to secondary lymphoid organs, divides human memory T cells into two functionally distinct subsets, which are named central memory (TCM) and effector memory (TEM).
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Function of the chemokine receptor CXCR4 in haematopoiesis and in cerebellar development
TL;DR: This is the first demonstration of the involvement of a G-protein-coupled chemokine receptor in neuronal cell migration and patterning in the central nervous system and may be important for designing strategies to block HIV entry into cells and for understanding mechanisms of pathogenesis in AIDS dementia.
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Defects of B-cell lymphopoiesis and bone-marrow myelopoiesis in mice lacking the CXC chemokine PBSF/SDF-1
Takashi Nagasawa,Seiichi Hirota,Kazunobu Tachibana,Nobuyuki Takakura,Shin-Ichi Nishikawa,Yukihiko Kitamura,Nobuaki Yoshida,Hitoshi Kikutani,Tadamitsu Kishimoto +8 more
TL;DR: It is shown that the chemokine PBSF/SDF-1 has several essential functions in development, including B-cell lymphopoiesis and bone-marrow myelopoiedis and a cardiac ventricular septal defect.
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CCR7 coordinates the primary immune response by establishing functional microenvironments in secondary lymphoid organs.
Reinhold Förster,Andreas Schubel,Dagmar Breitfeld,Elisabeth Kremmer,Ingrid Renner-Müller,Eckhard Wolf,Martin Lipp +6 more
TL;DR: In this paper, the chemokine receptor CCR7 was identified as an important organizer of the primary immune response in mice, and severely delayed kinetics regarding the antibody response and lack contact sensitivity and delayed type hypersensitivity reactions.
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A new class of membrane-bound chemokine with a CX3C motif
J F Bazan,Kevin B. Bacon,Gary Hardiman,W Wang,K Soo,Devora L. Rossi,David R. Greaves,Albert Zlotnik,T J Schall +8 more
TL;DR: The structure, biochemical features, tissue distribution and chromosomal localization of CX3C chemokine all indicate that it represents a unique class of chemokines that may constitute part of the molecular control of leukocyte traffic at the endothelium.