Chemokines: A New Classification System and Their Role in Immunity
Albert Zlotnik,Osamu Yoshie +1 more
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This article is published in Immunity.The article was published on 2000-02-01 and is currently open access. It has received 3852 citations till now. The article focuses on the topics: CCL7.read more
Citations
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Innate Immunity to Mycobacterium tuberculosis
TL;DR: Different natural effector mechanisms for killing of M. tuberculosis have now been identified and these basic mechanisms augment the understanding of disease pathogenesis and clinical course and will be of help in designing adjunctive treatment strategies.
Journal ArticleDOI
Matrix metalloproteinase processing of monocyte chemoattractant proteins generates CC chemokine receptor antagonists with anti-inflammatory properties in vivo
G. Angus McQuibban,Jiang-Hong Gong,Julie P. Wong,John L. Wallace,Ian Clark-Lewis,Christopher M. Overall +5 more
TL;DR: It is proposed that MMPs have an important role in modulating inflammatory and immune responses by processing chemokines in wound healing and in disease.
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The immune system and cardiac repair
TL;DR: Targeting inflammatory pathways following infarction may reduce cardiomyocyte injury and attenuate adverse remodeling, and understanding the role of the immune system in cardiac repair is necessary in order to design optimal strategies for cardiac regeneration.
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Lymphocyte CC chemokine receptor 9 and epithelial thymus-expressed chemokine (TECK) expression distinguish the small intestinal immune compartment: Epithelial expression of tissue-specific chemokines as an organizing principle in regional immunity.
Eric J. Kunkel,James Campbell,Guttorm Haraldsen,Junliang Pan,Judie Boisvert,Arthur I. Roberts,Ellen C. Ebert,Mark A. Vierra,Stuart B. Goodman,Mark C. Genovese,Andrew J. Wardlaw,Harry B. Greenberg,Christina M. Parker,Eugene C. Butcher,David P. Andrew,William W. Agace +15 more
TL;DR: Results imply a restricted role for lymphocyte CCR9 and its ligand TECK in the small intestine, and provide the first evidence for distinctive mechanisms of lymphocyte recruitment that may permit functional specialization of immune responses in different segments of the gastrointestinal tract.
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Multiplexed protein profiling on microarrays by rolling-circle amplification
Barry Schweitzer,Scott Roberts,Brian Grimwade,Weiping Shao,Minjuan Wang,Qin Fu,Quiping Shu,Isabelle Laroche,Zhimin Zhou,Velizar T. Tchernev,Jason Christiansen,Mark Velleca,Stephen F. Kingsmore +12 more
TL;DR: Coupling of isothermal rolling-circle amplification (RCA) to universal antibodies for this purpose is described, and LPS induced rapid secretion of inflammatory cytokines such as macrophage inflammatory protein (MIP)-1β, interleukin (IL)-8, and interferon-inducible protein (IP)-10 are found.
References
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Two subsets of memory T lymphocytes with distinct homing potentials and effector functions
TL;DR: It is shown that expression of CCR7, a chemokine receptor that controls homing to secondary lymphoid organs, divides human memory T cells into two functionally distinct subsets, which are named central memory (TCM) and effector memory (TEM).
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Function of the chemokine receptor CXCR4 in haematopoiesis and in cerebellar development
TL;DR: This is the first demonstration of the involvement of a G-protein-coupled chemokine receptor in neuronal cell migration and patterning in the central nervous system and may be important for designing strategies to block HIV entry into cells and for understanding mechanisms of pathogenesis in AIDS dementia.
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Defects of B-cell lymphopoiesis and bone-marrow myelopoiesis in mice lacking the CXC chemokine PBSF/SDF-1
Takashi Nagasawa,Seiichi Hirota,Kazunobu Tachibana,Nobuyuki Takakura,Shin-Ichi Nishikawa,Yukihiko Kitamura,Nobuaki Yoshida,Hitoshi Kikutani,Tadamitsu Kishimoto +8 more
TL;DR: It is shown that the chemokine PBSF/SDF-1 has several essential functions in development, including B-cell lymphopoiesis and bone-marrow myelopoiedis and a cardiac ventricular septal defect.
Journal ArticleDOI
CCR7 coordinates the primary immune response by establishing functional microenvironments in secondary lymphoid organs.
Reinhold Förster,Andreas Schubel,Dagmar Breitfeld,Elisabeth Kremmer,Ingrid Renner-Müller,Eckhard Wolf,Martin Lipp +6 more
TL;DR: In this paper, the chemokine receptor CCR7 was identified as an important organizer of the primary immune response in mice, and severely delayed kinetics regarding the antibody response and lack contact sensitivity and delayed type hypersensitivity reactions.
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A new class of membrane-bound chemokine with a CX3C motif
J F Bazan,Kevin B. Bacon,Gary Hardiman,W Wang,K Soo,Devora L. Rossi,David R. Greaves,Albert Zlotnik,T J Schall +8 more
TL;DR: The structure, biochemical features, tissue distribution and chromosomal localization of CX3C chemokine all indicate that it represents a unique class of chemokines that may constitute part of the molecular control of leukocyte traffic at the endothelium.