Chemokines: A New Classification System and Their Role in Immunity
Albert Zlotnik,Osamu Yoshie +1 more
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This article is published in Immunity.The article was published on 2000-02-01 and is currently open access. It has received 3852 citations till now. The article focuses on the topics: CCL7.read more
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CCL9/MIP‐1γ and its receptor CCR1 are the major chemokine ligand/receptor species expressed by osteoclasts
TL;DR: CCL9 and its receptor CCR1 are identified as the major chemokine and receptor species expressed by osteoclasts, and a crucial role for CCL9 in the regulation of bone resorption is suggested.
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T-cells in the cerebrospinal fluid express a similar repertoire of inflammatory chemokine receptors in the absence or presence of CNS inflammation: implications for CNS trafficking.
Pia Kivisäkk,Corinna Trebst,Zhugong Liu,Barbara Tucky,Torben Lykke Sørensen,Richard A. Rudick,Matthias Mack,Richard M. Ransohoff +7 more
TL;DR: The aim of the current study was to define the expression on cerebrospinal fluid T‐cells of six chemokine receptors associated with trafficking to sites of inflammation, and hypothesize that CXCR3 is the principal inflammatory chemokines and their receptors involved in intrathecal accumulation of T‐ cells in MS.
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IFN-alpha beta released by Mycobacterium tuberculosis-infected human dendritic cells induces the expression of CXCL10: selective recruitment of NK and activated T cells.
Roberto Lande,Elena Giacomini,Tiziana Grassi,Maria Elena Remoli,Elisabetta Iona,Minja Miettinen,Ilkka Julkunen,Eliana M. Coccia +7 more
TL;DR: It is shown that maturing Mtb-infected DC express high levels of CCR7 and they become responsive to its ligand CCL21, which indicates that IFN-αβ may modulate the immune response through the expression of CXCL10, which along with CXcl9, CCL3, and CCL4 participates in the recruitment and selective homing of activated/effector cells.
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The chemokine system in neuroinflammation: an update.
TL;DR: This review summarizes recent information about the expression and function of elements of the chemokine system in CNS inflammatory processes and animal models of CNS demyelinating disease and the corresponding human disorder, multiple sclerosis are considered.
References
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Two subsets of memory T lymphocytes with distinct homing potentials and effector functions
TL;DR: It is shown that expression of CCR7, a chemokine receptor that controls homing to secondary lymphoid organs, divides human memory T cells into two functionally distinct subsets, which are named central memory (TCM) and effector memory (TEM).
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Function of the chemokine receptor CXCR4 in haematopoiesis and in cerebellar development
TL;DR: This is the first demonstration of the involvement of a G-protein-coupled chemokine receptor in neuronal cell migration and patterning in the central nervous system and may be important for designing strategies to block HIV entry into cells and for understanding mechanisms of pathogenesis in AIDS dementia.
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Defects of B-cell lymphopoiesis and bone-marrow myelopoiesis in mice lacking the CXC chemokine PBSF/SDF-1
Takashi Nagasawa,Seiichi Hirota,Kazunobu Tachibana,Nobuyuki Takakura,Shin-Ichi Nishikawa,Yukihiko Kitamura,Nobuaki Yoshida,Hitoshi Kikutani,Tadamitsu Kishimoto +8 more
TL;DR: It is shown that the chemokine PBSF/SDF-1 has several essential functions in development, including B-cell lymphopoiesis and bone-marrow myelopoiedis and a cardiac ventricular septal defect.
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CCR7 coordinates the primary immune response by establishing functional microenvironments in secondary lymphoid organs.
Reinhold Förster,Andreas Schubel,Dagmar Breitfeld,Elisabeth Kremmer,Ingrid Renner-Müller,Eckhard Wolf,Martin Lipp +6 more
TL;DR: In this paper, the chemokine receptor CCR7 was identified as an important organizer of the primary immune response in mice, and severely delayed kinetics regarding the antibody response and lack contact sensitivity and delayed type hypersensitivity reactions.
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A new class of membrane-bound chemokine with a CX3C motif
J F Bazan,Kevin B. Bacon,Gary Hardiman,W Wang,K Soo,Devora L. Rossi,David R. Greaves,Albert Zlotnik,T J Schall +8 more
TL;DR: The structure, biochemical features, tissue distribution and chromosomal localization of CX3C chemokine all indicate that it represents a unique class of chemokines that may constitute part of the molecular control of leukocyte traffic at the endothelium.