Chemokines: A New Classification System and Their Role in Immunity
Albert Zlotnik,Osamu Yoshie +1 more
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This article is published in Immunity.The article was published on 2000-02-01 and is currently open access. It has received 3852 citations till now. The article focuses on the topics: CCL7.read more
Citations
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Platelet chemokines in health and disease
TL;DR: This review gives a concise overview and an update on the current understanding of platelet-derived chemokines in a context of health and disease.
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Molecular Dynamics Simulations on SDF-1α: Binding with CXCR4 Receptor
Xiaoqin Huang,Jianhua Shen,Meng Cui,Lingling Shen,Xiaomin Luo,Kun Ling,Gang Pei,Hualiang Jiang,Kaixian Chen +8 more
TL;DR: A binding mechanism hypothesis between CXCR4 and SDF-1α and its relationship to the signal transduction has been proposed and is in agreement with most of the experimental data.
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Sentinel lymph node as a target of molecular diagnosis of lymphatic micrometastasis and local immunoresponse to malignant cells
TL;DR: There is now a growing body of data to support the clinical relevance of SLN micrometastasis in a variety of solid tumors and a novel immunotherapy that overcomes tumor‐induced immune suppression and can prevent or eradicate SLN metastasis is developed.
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Rho kinase is required for CCR7-mediated polarization and chemotaxis of T lymphocytes.
TL;DR: An important role of Rho kinase is indicated in CCR7‐mediated polarization and migration of T lymphocytes, whereas ERK‐2 is not involved in these processes.
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Interaction between neoplastic cells and cancer-associated fibroblasts through the CXCL12/CXCR4 axis: Role in non–small cell lung cancer tumor proliferation
Ori Wald,Uzi Izhar,Gail Amir,Sophie Kirshberg,Zippora Shlomai,Gideon Zamir,Amnon Peled,Oz M. Shapira +7 more
TL;DR: Interaction between carcinoma-associated fibroblasts and tumor epithelial cells through the CXCL12/CXCR4 axis plays a role in non-small cell lung cancer tumor proliferation, marking this axis as a target for immune intervention.
References
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Two subsets of memory T lymphocytes with distinct homing potentials and effector functions
TL;DR: It is shown that expression of CCR7, a chemokine receptor that controls homing to secondary lymphoid organs, divides human memory T cells into two functionally distinct subsets, which are named central memory (TCM) and effector memory (TEM).
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Function of the chemokine receptor CXCR4 in haematopoiesis and in cerebellar development
TL;DR: This is the first demonstration of the involvement of a G-protein-coupled chemokine receptor in neuronal cell migration and patterning in the central nervous system and may be important for designing strategies to block HIV entry into cells and for understanding mechanisms of pathogenesis in AIDS dementia.
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Defects of B-cell lymphopoiesis and bone-marrow myelopoiesis in mice lacking the CXC chemokine PBSF/SDF-1
Takashi Nagasawa,Seiichi Hirota,Kazunobu Tachibana,Nobuyuki Takakura,Shin-Ichi Nishikawa,Yukihiko Kitamura,Nobuaki Yoshida,Hitoshi Kikutani,Tadamitsu Kishimoto +8 more
TL;DR: It is shown that the chemokine PBSF/SDF-1 has several essential functions in development, including B-cell lymphopoiesis and bone-marrow myelopoiedis and a cardiac ventricular septal defect.
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CCR7 coordinates the primary immune response by establishing functional microenvironments in secondary lymphoid organs.
Reinhold Förster,Andreas Schubel,Dagmar Breitfeld,Elisabeth Kremmer,Ingrid Renner-Müller,Eckhard Wolf,Martin Lipp +6 more
TL;DR: In this paper, the chemokine receptor CCR7 was identified as an important organizer of the primary immune response in mice, and severely delayed kinetics regarding the antibody response and lack contact sensitivity and delayed type hypersensitivity reactions.
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A new class of membrane-bound chemokine with a CX3C motif
J F Bazan,Kevin B. Bacon,Gary Hardiman,W Wang,K Soo,Devora L. Rossi,David R. Greaves,Albert Zlotnik,T J Schall +8 more
TL;DR: The structure, biochemical features, tissue distribution and chromosomal localization of CX3C chemokine all indicate that it represents a unique class of chemokines that may constitute part of the molecular control of leukocyte traffic at the endothelium.